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Research ArticlePediatric Neuroimaging

Balanced Steady-State Free Precession Sequence (CISS/FIESTA/3D Driven Equilibrium Radiofrequency Reset Pulse) Increases the Diagnostic Yield for Spinal Drop Metastases in Children with Brain Tumors

K. Buch, P. Caruso, D. Ebb and S. Rincon
American Journal of Neuroradiology July 2018, 39 (7) 1355-1361; DOI: https://doi.org/10.3174/ajnr.A5645
K. Buch
aFrom the Department of Neuroradiology (K.B., P.C., S.R.), Massachusetts General Hospital, Boston, Massachusetts
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P. Caruso
aFrom the Department of Neuroradiology (K.B., P.C., S.R.), Massachusetts General Hospital, Boston, Massachusetts
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D. Ebb
bDepartment of Pediatrics (D.E.), Pediatric Cancer Care Center, Massachusetts General Hospital for Children, Boston, Massachusetts.
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S. Rincon
aFrom the Department of Neuroradiology (K.B., P.C., S.R.), Massachusetts General Hospital, Boston, Massachusetts
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    Fig 1.

    Classification by cases (left image) with positive, negative, and indeterminate findings on the bSSFP and postcontrast T1WI. Classification by nodules (right image) with positive, negative, and indeterminate findings.

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    Fig 2.

    A 6-year-old boy with a history of medulloblastoma. Sagittal bSSFP images A and C demonstrate numerous nodular drop metastases (white arrows). B and D, Corresponding enhancing nodules along the cauda equina nerve roots. The axial bSSFP image (E) demonstrates a nodular drop metastasis along the cauda equina nerve roots (white arrow).

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    Fig 3.

    A 4-year-old boy with a history of medulloblastoma and diffuse leptomeningeal disease. The bSSFP image of the cervical spine (A) demonstrates subtle irregularity of the cervicothoracic spinal cord. Abnormal, confluent enhancement is more pronounced on the sagittal postcontrast T1WI of the cervicothoracic spine (B). The axial bSSFP image (C) demonstrates abnormal, crescentic signal abnormality along the dorsal spinal cord.

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    Fig 4.

    An 8-year-old boy with a history of germinoma. Sagittal bSSFP sequence (A) demonstrates a nodular drop metastasis within the cauda equina nerve roots (white arrowhead). No corresponding enhancement is seen on the postcontrast T1WI (B). The axial bSSFP sequence (C) demonstrates a nodular drop metastasis along the cauda equina nerve roots (white arrow) within the left lateral aspect of the thecal sac.

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    Fig 5.

    A 7-year-old boy with a history of ependymoma. A, Sagittal bSSFP sequence demonstrates a dominant, ventral spinal metastasis at the T5 level (white arrow) with multiple, additional, smaller metastases (white arrowhead). B, Axial bSSFP sequence at the T5 level demonstrates a left ventral metastasis (white arrowhead). C, Postcontrast T1WI in the same patient does not demonstrate abnormal enhancement or detectable drop metastases.

Tables

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    Table 1:

    Demographic and clinical information for the 44-patient cohort

    Patient Demographics
    Sex
        Male27
        Female17
    Age (yr)
        Mean7.21
        SD4.24
        Min1
        Max18
    Primary intracranial tumor type
        Medulloblastoma15
        Germinoma11
        Ependymoma8
        Astrocytoma4
        ATRT3
        Glioblastoma2
        Pineoblastoma1
    • Note:—Min indicates minimum; max, maximum; ATRT, atypical rhabdoid tumor.

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    Table 2:

    Number of cases with nodules meeting the criteria for drop metastases (positive cases), cases with no evidence of drop metastases (negative cases), and cases with indeterminate findingsa

    SequencePositive CasesNegative CasesIndeterminate Cases
    bSSFP10340
    Postcontrast T1WI8324
    • ↵a This classification was performed for both the bSSFP and postcontrast T1WI, which were evaluated independently.

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    Table 3:

    Total number of lesions, lesion size, and number of lesions of ≤3 mm detected on the bSSFP sequence compared with postcontrast T1WI

    bSSFPPostcontrast T1WIP Value
    No. of lesions per patient
        Mean6.32.1.002
        SD3.91.2
        Min21
        Max134
    Lesion size (mm)
        Mean3.94.9.43
        SD4.66.8
        Min11
        Max2524
    Lesions ≤3 mm
        Mean3.91.2.03
        SD2.11.7
    • Note:—Min indicates minimum; max, maximum.

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    Table 4:

    Number of nodules seen on the bSSFP and postcontrast T1WI classified as positive nodules, indeterminate nodules, and discordant nodulesa

    Nodule ClassificationbSSFPPostcontrast T1WI
    Positive nodules3614
    Indeterminate nodules010
    Discordant nodules022
    • ↵a Discordant or “missed” nodules are nodules not seen on the sequence being evaluated but present on the corresponding sequence. In this case, 22 nodules were not seen on postcontrast T1WI that were seen on the bSSFP sequence. No nodules were seen on the postcontrast T1WI but not the bSSFP sequence.

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American Journal of Neuroradiology: 39 (7)
American Journal of Neuroradiology
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Balanced Steady-State Free Precession Sequence (CISS/FIESTA/3D Driven Equilibrium Radiofrequency Reset Pulse) Increases the Diagnostic Yield for Spinal Drop Metastases in Children with Brain Tumors
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K. Buch, P. Caruso, D. Ebb, S. Rincon
Balanced Steady-State Free Precession Sequence (CISS/FIESTA/3D Driven Equilibrium Radiofrequency Reset Pulse) Increases the Diagnostic Yield for Spinal Drop Metastases in Children with Brain Tumors
American Journal of Neuroradiology Jul 2018, 39 (7) 1355-1361; DOI: 10.3174/ajnr.A5645

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Balanced Steady-State Free Precession Sequence (CISS/FIESTA/3D Driven Equilibrium Radiofrequency Reset Pulse) Increases the Diagnostic Yield for Spinal Drop Metastases in Children with Brain Tumors
K. Buch, P. Caruso, D. Ebb, S. Rincon
American Journal of Neuroradiology Jul 2018, 39 (7) 1355-1361; DOI: 10.3174/ajnr.A5645
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