Article Figures & Data
Figures
- Fig 1.
The relationship between disease severity measured by the Unified Parkinson's Disease Rating Scale (UPDRS), Part III, and fractional anisotropy (A) and mean diffusivity (B) calculated from the whole-brain white matter tract skeleton.
- Fig 2.
Tract-Based Spatial Statistics results for decreased fractional anisotropy in patients with juvenile neuronal ceroid lipofuscinosis visualized on axial (A), coronal (B), and sagittal (C) slices. The white matter tract skeleton is visualized in green, and the significant results are visualized from red (P = .05) to yellow (P < .001). Fractional anisotropy values are significantly (P < .001) decreased in many areas such as the corpus callosum, corticospinal tracts, corona radiata, and superior longitudinal fasciculi.
- Fig 3.
Decreased fractional anisotropy in patients with juvenile neuronal ceroid lipofuscinosis in, for example, the left posterior thalamic radiation (P < .001) and left posterior corona radiata (P < .001) on sagittal slices 58 (A) and 79 (B). The white matter tract skeleton is visualized in green, and significant results are visualized from red (P = .05) to yellow (P < .001).
- Fig 4.
Tract-Based Spatial Statistics results for increased mean diffusivity in patients with juvenile neuronal ceroid lipofuscinosis visualized on axial (A), coronal (B), and sagittal (C) slices. The white matter tract skeleton is visualized in green, and the significant results are visualized from red (P = .05) to yellow (P < .001). Multiple areas but not as many as for fractional anisotropy (Fig 2) have significantly (P < .001) increased mean diffusivity values.
Tables
- Table 1:
Global microstructural differences between children with CLN3 and age-matched control group with both skeleton and tractography approaches
Measure Control CLN3 1st CLN3 2nd P Valuea (CLN3 1st vs Control) P Valuea (CLN3 2nd vs Control) P Valuea (CLN3 1st vs CLN3 2nd) FA (skeleton) .328 ± .026 .297 ± .021 .288 ± .029 <.001b <.001b .95 FA (tractogram) .271 ± .019 .233 ± .016 .224 ± .021 .000001b .000001b .82 MD (skeleton) .965 × 10−3 ± .0582 × 10−3 1.011 × 10−3 ± .0806 × 10−3 1.057 × 10−3 ± .119 × 10−3 .01b .005b .89 MD (tractogram) .957 × 10−3 ± .0506 × 10−3 1.036 × 10−3 ± .0882 × 10−3 1.108 × 10−3 ± .131 × 10−3 <.001b <.001b .43 AD (skeleton) 1.29 × 10−3 ± .0614 × 10−3 1.31 × 10−3 ± .0769 × 10−3 1.36 × 10−3 ± .112 × 10−3 .12 .04b .83 AD (tractogram) 1.22 × 10−3 ± .0506 × 10−3 1.28 × 10−3 ± .0803 × 10−3 1.34 × 10−3 ± .122 × 10−3 .008b <.001b .39 RD (skeleton) .801 × 10−3 ± .0578 × 10−3 .859 × 10−3 ± .0849 × 10−3 .907 × 10−3 ± .126 × 10−3 .003b .002b .93 RD (tractogram) .823 × 10−3 ± .0512 × 10−3 .917 × 10−3 ± .0927 × 10−3 .990 × 10−3 ± .136 × 10−3 <.001b <.001b .45 CP (skeleton) .169 ± .0135 .163 ± .0125 .157 ± .0146 .04b .03b .73 CP (tractogram) .141 ± .0113 .129 ± .00633 .126 ± .00866 <.001b <.001b .93
