Improved Detection of New MS Lesions during Follow-Up Using an Automated MR Coregistration-Fusion Method

Automated MR imaging coregistration-fusion method. A, First step of the CF method: Two 3D-FLAIR images in the axial plane (the previous one on the left and the new one on the right) appear side by side. Note that the ventricles and cerebral sulci are different in size and orientation due to differences in laterolateral and anteroposterior orientation in the image acquisition. B, Second step of CF method: The 2 examinations are perfectly coregistered and linked so that the images can be scrolled together to display the same anatomic level. C, Third step: The previous (left) examination and the current one (middle) are merged, and the fusion image (right) is automatically artificially colored blue. All the pre-existing lesions are blue (black arrowheads), whereas the new ones are white (white arrowheads), highlighting their presence to the reader.