Article Figures & Data
Figures
- Fig 1.
Vermian CCD (the MR imaging trait with the worst percentage disagreement in accuracy between the 2 assessors). Bland-Altman plot of the interassessor B–A difference versus the mean of the measures made on a single fetus. Dashed lines are the limits of agreement for the B–A difference: Ninety-five percent of these differences are expected to lie within these limits when the agreement between the 2 assessors is perfect.
- Fig 2.
Pontine APD (the MR imaging trait with the highest correlation of disagreement in accuracy between the 2 assessors and size of MR imaging trait). Bland-Altman plot of the interassessor B–A difference versus the mean of the measures made on a single fetus. Dashed lines are the limits of agreement for the B–A difference: Ninety-five percent of these differences are expected to lie within these limits when the agreement between the 2 assessors is perfect.
- Fig 3.
Reference chart for cerebral FOD growth: a whole set of computed centiles (3rd, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97th) with observed values. Females are denoted by light gray dots, males by dark gray dots, and fetuses of sex unknown by white dots.
- Fig 4.
Reference chart for cerebral BPD growth: a whole set of computed centiles (3rd, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97th) with observed values. Females are denoted by light gray dots, males by dark gray dots, and fetuses of sex unknown by white dots.
Tables
Indication for Prenatal MRI No. of Fetuses (%) Unclear CNS findings at ultrasound 80 (47) Extra-CNS disease or malformation 30 (18) Previous child with a confirmed CNS malformation 59 (35) No.a Meanb B-Ac B-A (%)d t Teste P SEMf CVSEMg rh P PCF 165 28.61 0.022 0.08 0.17 1.148 4.01 0.059 Cerebral FOD 168 56.77 −3.258 −5.74 −18.53 <.01 1.611 2.84 0.158 <.05 Cerebral BPD 169 42.12 −1.263 −3.00 −11.68 <.01 0.995 2.36 −0.141 Vermian APD 167 7.08 0.014 0.20 0.21 0.611 8.64 0.192 <.05 Cerebellar LLD 166 21.81 −1.020 −4.68 −10.41 <.01 0.893 4.09 0.111 Vermian CCD 168 10.13 −0.934 −9.22 −13.29 <.01 0.644 6.36 −0.004 CSA 168 72.25 1.020 1.41 1.77 5.278 7.30 0.192 <.05 LCC 152 17.97 0.176 0.98 1.75 0.878 4.89 0.071 LCC/cerebral FOD (%) 151 31.69 2.252 7.11 11.87 <.01 1.648 5.20 0.238 <.01 Thecal FOD 167 63.47 0.360 0.57 2.97 <.01 1.106 1.74 0.002 Thecal BPD 169 49.74 0.682 1.37 4.45 <.01 1.410 2.83 0.106 Mesencephalic APD 118 4.46 0.197 4.41 3.08 <.01 0.490 10.99 0.143 Pontine APD 159 6.69 −0.074 −1.10 −1.34 0.491 7.34 0.241 <.01 Pontine CCD 158 7.53 −0.384 −5.10 −6.24 <.01 0.547 7.27 0.184 <.05 Lateral ventricles 161 6.76 0.568 8.40 8.15 <.01 0.625 9.25 −0.214 <.01 Note:—SEM indicates standard error of the measurements; APD, antero-posterior diameter; BPD, biparietal diameter; CCD, cranio-caudal diameter; CV, coefficient of variation; CSA, clivosupraoccipital angle; LCC, length of the corpus callosum; LLD, latero-lateral diameter; FOD, fronto-occipital diameter; PCF, latero-lateral diameter of the posterior cranial fossa.
↵a The number of observations.
↵b Mean of all measurements.
↵c Mean difference between assessor B and assessor A (difference in accuracy of assessors A and B).
↵d Percentage interassessor difference [100 × (B−A) / mean].
↵e t test for difference in B−A.
↵f Measuring error—that is, the SD of the measures of the same fetus (lack of precision).
↵g Measuring error expressed as coefficient of variation (%) of (100 × SEM / mean).
↵h Correlation coefficient between interassessor B−A difference and the mean of the measurements made on a single fetus.
- Table 3:
Median and reference limits (5th and 95th centiles) for MR imaging traits between 20 and 24 completed weeks of gestation
20 Weeks 21 Weeks 22 Weeks 23 Weeks 24 Weeks 5th 50th 95th 5th 50th 95th 5th 50th 95th 5th 50th 95th 5th 50th 95th PCF 23.3 26.3 29.3 24.6 27.8 31.1 25.9 29.3 32.9 27.2 30.8 34.7 28.5 32.4 36.5 Cerebral FOD 46.7 51.2 56.4 50.1 54.8 60.2 53.4 58.4 64.1 56.8 62.0 67.9 60.2 65.5 71.7 Cerebral BPD 36.2 38.7 41.6 37.8 40.9 44.5 39.4 43.0 47.4 40.9 45.2 50.5 42.4 47.3 53.6 Vermian APD 5.5 6.3 7.2 6.0 6.8 7.8 6.4 7.3 8.4 6.8 7.8 9.0 7.2 8.3 9.6 Cerebellar LLD 18.2 19.9 21.8 19.1 21.1 23.4 20.1 22.4 25.0 21.0 23.6 26.6 21.9 24.9 28.3 Vermian CCD 7.7 9.0 10.0 8.3 9.8 10.9 8.9 10.6 11.9 9.5 11.4 12.8 10.1 12.1 13.8 CSA 63.7 71.0 79.9 63.6 71.6 81.5 63.4 72.1 83.2 63.2 72.7 85.0 63.1 73.2 86.8 LCC 13.3 15.3 17.1 14.7 17.1 19.2 16.0 18.9 21.4 17.3 20.7 23.6 18.6 22.5 25.8 LCC/cerebral FOD (%) 27.3 29.9 32.5 27.8 31.1 34.3 28.3 32.3 36.1 28.7 33.5 38.0 29.1 34.7 39.9 Thecal FOD 53.4 57.5 62.1 56.7 61.3 66.6 60.0 65.2 71.2 63.2 69.0 75.7 66.4 72.8 80.4 Thecal BPD 42.1 45.7 49.9 44.4 48.3 52.9 46.7 50.9 56.0 49.0 53.6 59.1 51.3 56.2 62.1 Mesencephalic APD 3.6 4.4 5.2 3.7 4.5 5.2 3.8 4.5 5.3 3.8 4.6 5.3 3.9 4.6 5.3 Pontine APD 5.5 6.2 6.9 5.7 6.5 7.3 6.0 6.8 7.7 6.3 7.1 8.0 6.5 7.4 8.4 Pontine CCD 6.3 7.1 7.9 6.5 7.4 8.3 6.7 7.7 8.7 6.8 8.0 9.0 7.0 8.2 9.4 Lateral ventricles 5.7 7.0 8.4 5.3 6.8 8.4 5.0 6.6 8.4 4.7 6.4 8.5 4.5 6.3 8.5 Note:—APD indicates antero-posterior diameter; BPD, biparietal diameter; CCD, cranio-caudal diameter; CSA, clivosupraoccipital angle; LCC, length of the corpus callosum; LLD, latero-lateral diameter; FOD, fronto-occipital diameter; PCF, latero-lateral diameter of the posterior cranial fossa.
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