Article Figures & Data
Figures
- Fig 1.
Examples of the 5 voxel locations used for brain MR spectroscopy in the left frontal white matter, left hippocampus (Hippo), left basal ganglia (BG), mesial posterior cingulate cortex, and mesial precuneus. An example of a spectrum from the PC in a 55-year-old HIV+ subject is shown, including results from the LCModel analysis (red curve). Signals are assigned to lipids (Lip), N-acetylaspartate, N-acetyl aspartylglutamate (NAAG), glutamate, glutamine (Gln), creatine, choline, myoinositol (mI), and Glx (the sum of Glu and Gln). The top trace is the difference between the original data and the results of the curve fit.
- Fig 2.
Metabolite ratios for the frontal white matter, posterior cingulate, precuneus, basal ganglia, and hippocampal voxels. Asterisk indicates significant; GABA, γ-aminobutyric acid; IQR, interquartile range; mI, myoinositol.
- Fig 3.
Metabolite concentrations in institutional units for the frontal white matter, posterior cingulate, precuneus, basal ganglia, and hippocampal voxels. Asterisk indicates significant, GABA, γ-aminobutyric acid; IQR, interquartile range; mI, myoinositol.
- Fig 4.
Scatterplots showing significant positive correlations of FWM Glu/Cr with the Hopkins Verbal Learning Test (HVLT) delayed recall, and FWM tNAA/Cr with the Grooved Pegboard non-dominant hand, Digit Symbol, and Trail-Making Test B z scores.
- Fig 5.
Scatterplots showing significant positive correlation of the posterior cingulate tNAA/Cr with the Digit Symbol and Stroop test z scores.
- Fig 6.
Scatterplots showing significant positive correlation of the precuneus NAA/Cr and Glu/Cr with Stroop test and Trail-Making Part B z scores, respectively.
Tables
Subject demographics in the 2 HIV+ groups: asymptomatic neurocognitive impairment and symptomatic HIV-associated neurocognitive disordera
ANI HAND P Value No. 24 21 – Age (yr) 59.6 ± 5.7 58.2 ± 5.0 .378 Male sex (No.) (%) 17 (71%) 16 (76%) .764 Education (yr) 14.9 ± 3.0 14.0 ± 2.7 .263 Race (% African American) 12 (50%) 13 (62%) .655 Duration of infection (yr) 19.9 ± 9.0 19.2 ± 9.4 .790 CES-D 7.7 ± 6.8 11.0 ± 11.7 .253 HART Est IQb 112.9 ± 12.8 103.7 ± 12.9 .022 CD4 cell count (cells/mm3) 674 ± 281 676 ± 375 .988 Plasma HIV RNA (Log10 copies/mL)c 1.6 ± 0.1 2.3 ± 1.4 .569 Note:—ANI indicates asymptomatic neurocognitive impairment; CES-D = Center for Epidemiological Studies Depression Scale; HART Est IQ = Hopkins Adult Reading Test estimated intelligence quotient.
↵a Values given are mean ± SD unless otherwise indicated.
↵b Significant (P < .05).
↵c Plasma HIV RNA only among those with detectable viral load (n = 2 ANI and n = 3 HAND).
Jump to section
Related Articles
Cited By...
- No citing articles found.