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Research ArticleHead and Neck Imaging

Intranasal Esthesioneuroblastoma: CT Patterns Aid in Preventing Routine Nasal Polypectomy

M.E. Peckham, R.H. Wiggins, R.R. Orlandi, Y. Anzai, W. Finke and H.R. Harnsberger
American Journal of Neuroradiology February 2018, 39 (2) 344-349; DOI: https://doi.org/10.3174/ajnr.A5464
M.E. Peckham
aFrom the Departments of Radiology and Imaging Sciences (M.E.P., R.H.W., Y.A., W.F., H.R.H.)
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R.H. Wiggins III
aFrom the Departments of Radiology and Imaging Sciences (M.E.P., R.H.W., Y.A., W.F., H.R.H.)
bDivision of Otolaryngology–Head and Neck Surgery (R.H.W., R.R.O.)
cBioMedical Informatics (R.H.W.), University of Utah Health Sciences Center, Salt Lake City, Utah.
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R.R. Orlandi
bDivision of Otolaryngology–Head and Neck Surgery (R.H.W., R.R.O.)
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Y. Anzai
aFrom the Departments of Radiology and Imaging Sciences (M.E.P., R.H.W., Y.A., W.F., H.R.H.)
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  • ORCID record for Y. Anzai
W. Finke
aFrom the Departments of Radiology and Imaging Sciences (M.E.P., R.H.W., Y.A., W.F., H.R.H.)
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H.R. Harnsberger
aFrom the Departments of Radiology and Imaging Sciences (M.E.P., R.H.W., Y.A., W.F., H.R.H.)
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    Fig 1.

    Coronal bone algorithm CT of the sinuses in a healthy subject demonstrates normal thin and symmetric olfactory recesses (asterisks) between the midline nasal septum and the shared superior attachments of the middle and superior turbinates laterally.

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    Fig 2.

    Coronal bone algorithm CT (A and B) and coronal T2-weighted MR image (C) obtained prepolypectomy (A), and postpolypectomy (B and C) demonstrate a soft-tissue-density lesion (arrows) that extends to the cribriform plate and widens the right olfactory recess. Opacification of the paranasal sinuses cannot be differentiated from the lesion on CT; however, paranasal sinus T2 bright secretions are readily discerned on MR imaging from the lesion (arrow), which is isointense to gray matter (C). This patient required an additional anterior skull base resection once ENB was diagnosed after routine polypectomy.

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    Fig 3.

    Coronal bone algorithm CT (A and B) images obtained in a control subject with chronic sinusitis (A) and a subject with ENB (B). While there is asymmetric opacification of the right OR with extension to the cribriform plate in the subject with chronic sinusitis (A), the OR is not widened. This finding contrasts with that in the subject with ENB who demonstrates additional asymmetric widening/remodeling of the OR. Both subjects have opacification of the adjacent paranasal sinuses, which, in the subject with ENB, was found to represent tumor extension. The subject with ENB underwent additional anterior skull base resection surgery when ENB was found after routine polypectomy.

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    Fig 4.

    Receiver operating characteristic curves for reader 1 (A) and reader 2 (B). Sensitivity and specificity varied between both readers; however, the overall diagnostic accuracy was strong, with reader 1 showing an area under the curve of 0.85, and reader two, 0.81.

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American Journal of Neuroradiology: 39 (2)
American Journal of Neuroradiology
Vol. 39, Issue 2
1 Feb 2018
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Cite this article
M.E. Peckham, R.H. Wiggins, R.R. Orlandi, Y. Anzai, W. Finke, H.R. Harnsberger
Intranasal Esthesioneuroblastoma: CT Patterns Aid in Preventing Routine Nasal Polypectomy
American Journal of Neuroradiology Feb 2018, 39 (2) 344-349; DOI: 10.3174/ajnr.A5464

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Intranasal Esthesioneuroblastoma: CT Patterns Aid in Preventing Routine Nasal Polypectomy
M.E. Peckham, R.H. Wiggins, R.R. Orlandi, Y. Anzai, W. Finke, H.R. Harnsberger
American Journal of Neuroradiology Feb 2018, 39 (2) 344-349; DOI: 10.3174/ajnr.A5464
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