Article Figures & Data
Figures
- Fig 1.
DENSE imaging with ROI placement and measured displacement across the cardiac cycle from a 44-year-old woman with IIH (Patient 9). A, Sagittal magnitude image from pre-LP DENSE encoded for motion in the foot-to-head direction. An ROI has been placed in the midpons to avoid partial volume effects from CSF flow. B, Corresponding phase image from the pre-LP DENSE encoded for motion in the foot-to-head direction with ROI transferred from the magnitude image into the midpons for measurement to be propagated to all 12 images acquired across the cardiac cycle. C, Graph showing DENSE displacement in the foot-to-head direction across the cardiac cycle divided into 12 phases. The solid line shows the pre-LP displacements across the cardiac cycle, and the dotted line shows post-LP displacements across the cardiac cycle. Maximum displacement is calculated by subtracting the lowest value from the highest across the cardiac cycle for both the pre-LP and post-LP states. Note the increased displacement in the post-LP state.
- Fig 2.
Comparison of maximum pontine displacement in pre-LP, post-LP, and control groups. The maximum pontine displacement of an ROI in the central pons in the pre-LP IIH group was significantly lower than in the post-LP state within subjects (P < .001) and significantly lower than the control group (P = .01). The maximum pontine displacement in post-LP patients with IIH did not significantly differ from control subjects (P = .10). Values are shown in mean ± SD.
- Fig 3.
Correlation of measured CSF pressure and pontine displacement by DENSE. The maximum pontine displacement measured by DENSE correlates moderately with measured pressure (opening pressure or closing pressure) by CSF manometry (r = 0.49; P = .04).
Tables
- Table 1:
Pressure measurements, DENSE pontine displacements, and times between measurements in patients with IIH pre-LP and post-LP
Patient No. OP, cm H20 CP, cm H20 OP to CP Pressure Change, cm H20 OP to CP Pressure Change, % CSF Removed, cc Pre-LP DENSE, mm Post-LP DENSE, mm % Change Pre-LP DENSE to OP Time, min CP to Post-LP DENSE Time, min 1 26 15 11 −42 11 0.124 0.134 8 56 17 2 41 18 23 −56 16 0.022 0.059 164 95 48 3 36 17 19 −53 20 0.071 0.097 36 67 18 4 46 19 27 −59 22 0.047 0.087 86 204 35 5 40 16 24 −60 15 0.105 0.119 14 51 34 6 33 16 17 −52 15 0.037 0.051 39 39 21 7 35 15 20 −57 15 0.024 0.052 113 72 10 8 32 19 13 −41 14 0.078 0.085 8 41 30 9 49 26 23 −47 12 0.035 0.054 54 35 26 Note:—CP indicates closing pressure; OP, opening pressure.
