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Research ArticleNeurointervention

Low Wall Shear Stress Is Associated with Local Aneurysm Wall Enhancement on High-Resolution MR Vessel Wall Imaging

W. Xiao, T. Qi, S. He, Z. Li, S. Ou, G. Zhang, X. Liu, Z. Huang and F. Liang
American Journal of Neuroradiology November 2018, 39 (11) 2082-2087; DOI: https://doi.org/10.3174/ajnr.A5806
W. Xiao
aFrom the Departments of Neurosurgery (W.X.,T.Q., S.O., G.Z., X.L., Z.H., F.L.)
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  • ORCID record for W. Xiao
T. Qi
aFrom the Departments of Neurosurgery (W.X.,T.Q., S.O., G.Z., X.L., Z.H., F.L.)
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S. He
bRadiology (S.H., Z.L.), The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
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Z. Li
bRadiology (S.H., Z.L.), The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
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S. Ou
aFrom the Departments of Neurosurgery (W.X.,T.Q., S.O., G.Z., X.L., Z.H., F.L.)
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G. Zhang
aFrom the Departments of Neurosurgery (W.X.,T.Q., S.O., G.Z., X.L., Z.H., F.L.)
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X. Liu
aFrom the Departments of Neurosurgery (W.X.,T.Q., S.O., G.Z., X.L., Z.H., F.L.)
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Z. Huang
aFrom the Departments of Neurosurgery (W.X.,T.Q., S.O., G.Z., X.L., Z.H., F.L.)
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F. Liang
aFrom the Departments of Neurosurgery (W.X.,T.Q., S.O., G.Z., X.L., Z.H., F.L.)
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    Fig 1.

    A, MRA shows a posterior communicating artery aneurysm (white arrow). B, Local enhancement on the aneurysmal wall on HR-VWI postgadolinium T1WI (large white arrow) compared with that of the pituitary infundibulum (small white arrow). C, Auto Fusion of HR-VWI T1WI (large white arrow) and TOF-MRA (small white arrow) images. D–F, Location of the enhanced area (highlighted in red) on the aneurysm (displayed in blue). G, Mean static pressure distribution. H, WSS distribution. The enhanced area has lower mean WSS (large black arrow) than the nonenhanced area (small black arrow). I and J, OSI distribution. The enhanced area has lower OSI (large black arrow) than the nonenhanced area (small black arrow).

  • Fig 2.
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    Fig 2.

    A, MRA shows a middle cerebral artery bifurcation aneurysm (white arrow). B, Local enhancement on the aneurysmal wall on HR-VWI postgadolinium T1WI (large white arrow) compared with that of the pituitary infundibulum (small white arrow). C, Auto Fusion of HR-VWI T1WI (large white arrow) and TOF-MRA (small white arrow) images. D–F, Location of enhanced area (highlighted in red) on the aneurysm (displayed in blue), G, Mean static pressure distribution. H, WSS distribution. The enhanced area has lower mean WSS (large black arrow) than the nonenhanced area (small black arrow). I and J, OSI distribution. The enhanced area has lower OSI (large black arrow) than the nonenhanced area (small black arrow).

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    Table 1:

    Hemodynamic comparison between enhanced and nonenhanced areasa

    VariablesEnhanced AreaNonenhanced AreaP Valueb
    P (Pa)183.2600 (97.4100–242.9950)158.8200 (103.5900–220.2000).115
    WSS (Pa)3.7255 (1.8487–8.3531)7.5342 (4.6062–11.1105).000c
    OSI0.2288 ± 0.09180.3008 ± 0.0890.021c
    • ↵a Data are expressed as means for normally distributed continuous variables, and as the median for non-normally distributed variables. Numbers in parentheses are interquartile range.

    • ↵b A P value < .05 was statistically significant.

    • ↵c Statistically significant.

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    Table 2:

    Hemodynamic comparison between the whole aneurysm and parent arterya

    VariablesWhole AneurysmParent ArteryP Valueb
    P (Pa)161.4600 (106.7050–220.5200)181.3400 (104.2630–268.1350).313
    WSS (Pa)6.8341 ± 3.72469.0612 ± 3.3256.000c
    OSI0.3402 ± 0.06290.2859 ± 0.0560.007c
    • ↵a Data are expressed as means for normally distributed continuous variables, and as the median for non-normally distributed variables. Numbers in parentheses are interquartile range.

    • ↵b A P value < .05 was statistically significant.

    • ↵c Statistically significant.

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American Journal of Neuroradiology: 39 (11)
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W. Xiao, T. Qi, S. He, Z. Li, S. Ou, G. Zhang, X. Liu, Z. Huang, F. Liang
Low Wall Shear Stress Is Associated with Local Aneurysm Wall Enhancement on High-Resolution MR Vessel Wall Imaging
American Journal of Neuroradiology Nov 2018, 39 (11) 2082-2087; DOI: 10.3174/ajnr.A5806

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Low Wall Shear Stress Is Associated with Local Aneurysm Wall Enhancement on High-Resolution MR Vessel Wall Imaging
W. Xiao, T. Qi, S. He, Z. Li, S. Ou, G. Zhang, X. Liu, Z. Huang, F. Liang
American Journal of Neuroradiology Nov 2018, 39 (11) 2082-2087; DOI: 10.3174/ajnr.A5806
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