Article Figures & Data
Figures
- Fig 1.
Example of cortical vascular territory ROIs drawn on the average map before gray-white matter segmentation.
- Fig 2.
Average MTT values in patients with good (A) and poor (B) grades with and without DCI. Note that the displayed y-axis MTT has been truncated (4–8 seconds in A and 5–7.5 seconds in B) to physiologic ranges to allow better visualization of the trends. Error bars represent the SDs (reflecting interindividual variation in MTT).
- Fig 3.
Representative MTT maps at days 0 and 3. A, Patient with good grade (WFNS I) who did not develop DCI. MTT on day 0 = 6.8 second; MTT on day 3 = 6.8 second. B, Patient with good grade (WFNS I) who developed DCI on day 5. MTT on day 0 = 7.4 second; MTT on day 3 = 10.2 second.
Tables
All (n = 87) Good Grade (n = 49) Poor Grade (n = 38) P Value Age (mean) (SD) (yr) 58.5 (13.2) 57.5 (12.8) 59.4 (13.9) .554 Female (No.) (%) 58 (67) 34 (69) 24 (63) .541 Smoking (No.) (%) 28 (32) 15 (31) 13 (34) .722 Hypertension (No.) (%) 41 (47) 19 (39) 22 (58) .076 GCS score (mean) (SD) 11.2 (4.6) 14.5 (0.8) 6.8 (3.8) <.001 mFisher grade (No.) (%) <.001 1 7 (8) 7 (14) 0 (0) 2 26 (30) 21 (43) 5 (13) 3 6 (7) 6 (12) 0 (0) 4 58 (55) 15 (31) 33 (87) Aneurysm treatment (No.) (%) .015 Clip 11 (13) 7 (14) 4 (11) Coil 70 (81) 42 (86) 28 (74) None 6 (6) 0 (0) 6 (16) Intracerebral hematoma (No.) (%) 64 (74) 8 (16) 15 (40) .03 Hydrocephalus (No.) (%) 57 (66) 27 (55) 30 (79) .02 Intracranial pressure (mean) (SD)a 28.7 (28.0) 15.3 (7.9) 36.8 (31.1) .005 Angiographic vasospasm (No.) (%) .377 CT 1 1 (1) 1 (2) 0 CT 2 10 (11) 6 (12) 4 (1) DCI (No.) (%) 13 (15) 9 (18) 4 (11) .309 Death (No.) (%) 12 (14) 0 (0) 12 (34) <.001 DCI or death (No.) (%) 25 (28) 9 (18) 16 (42) .015 Note:—mFisher indicates modified Fisher Scale; CT 1, before aneurysm treatment; CT 2, after aneurysm treatment.
↵a Data available in 15/49 patients with good grades and 31/38 with poor grades.
Good Grade Poor Grade All No DCI DCI All No DCI DCI or Death MTT 1 (SD) 6.3 (1.4) 6.2 (1.3) 6.6 (1.9) 7.7 (2.3)a 7.3 (1.7)a 8.3 (3.0)a MTT 2 (SD) 6.3 (1.7) 6.1 (1.5) 7.4 (2.5) 6.4 (1.9) 6.5 (2.1) 6.0 (0.8) MTTdiff (SD) 0.03 (1.2) −0.14 (0.98) 0.82 (1.6) −0.75 (1.7) −0.75 (1.8) −0.78 (1.6) ↵a Significantly greater than MTT1 in patients with good grades (P < .05).
All Good Grade Poor Grade OR 95% CI P Value OR 95% CI P Value OR 95% CI P Value Female 1.4 0.5–3.9 .504 0.86 0.18–4.0 .85 2.5 0.61–10.2 .2 Age 1.0 0.97–1.04 .512 0.96 0.90–1.0 .19 0.1 0.99–1.1 .09 Smoking 1.74 0.61–5.0 .303 0.86 0.18–4.0 .85 3.6 0.80–16.4 .096 Hypertension 1.5 0.59–3.80 .4 0.75 0.17–3.2 .7 4.44 1.12–17.7 .03a Hydrocephalus 0.66 0.24–1.8 .421 0.98 0.23–4.2 .98 0.78 0.16–3.9 .77 Hematoma 0.11 0.31–0.84 .021a 0.065 0.01–0.38 .002a 1.15 0.31–4.3 .832 GCS score 0.88 0.79–0.97 .01a 0.92 0.38–2.2 .85 0.92 0.77–1.1 .36 WFNS score 1.44 1.08–1.92 .013a mFisher Scale score 1.14 0.74–1.77 .554 0.48 0.21–1.1 .08 1.8 0.58–5.8 .3 Intracranial pressure 1 1.0–1.1 .013a 1.0 1.0–1.1 .03 0.89 0.68–1.2 .41 MTT1 1.3 1.0–1.6 .055 1.1 0.69–1.8 .66 1.21 0.89–1.6 .22 MTT2 1.16 0.87–1.55 .326 1.4 0.98–2.1 .06 0.85 0.51–1.4 .52 MTTdiff 1.24 0.82–1.86 .305 2.1 1.0–4.1 .04a 0.99 0.6–1.6 .97 Note:—mFisher indicates modified Fisher Scale.
↵a Significant.
All Good Grade Poor Grade OR 95% CI P Value OR 95% CI P Value OR 95% CI P Value WFNS grade 3.08 1.03–9.22 .04 GCS score 1.2 0.87–2.8 .31 0.57 0.17–1.9 .36 1.11 0.88–1.4 0.38 Hematoma 0.15 0.03–0.72 .02 0.03 0.003–0.34 .005 1.2 0.18–7.6 .87 MTTdiff 1.67 1.01–2.8 .04 3.1 1.3–7.4 .014 0.91 0.52–1.6 .73 - Table 5:
Optimal MTT thresholds and sensitivity and specificity (determined by the Youden Index) for DCI/deatha
Clinical Grade MTT1 MTT2 MTTdiff All 9.5 (26, 95) 5.5 (67, 48) 0.06 (47, 75) Good 6.5 (56, 73) 5.0 (100, 35) 0.2 (73, 37) Poor 9.6 (64, 90) 5.4 (88, 46) −0.33 (43, 65) ↵a MTT values in seconds with corresponding sensitivity and specificity (%, %).
