Spatial Correlation of Pathology and Perfusion Changes within the Cortex and White Matter in Multiple Sclerosis

References

1. 1.↵
   2. Rashid W,
   3. Parkes LM,
   4. Ingle GT, et al

   . Abnormalities of cerebral perfusion in multiple sclerosis. J Neurol Neurosurg Psychiatry 2004;75:1288–93 doi:10.1136/jnnp.2003.026021 pmid:15314117

   Abstract/FREE Full Text
2. 2.↵
   2. De Keyser J,
   3. Steen C,
   4. Mostert JP, et al

   . Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance. J Cereb Blood Flow Metab 2008;28:1645–51 doi:10.1038/jcbfm.2008.72 pmid:18594554

   CrossRefPubMed
3. 3.↵
   2. Sun X,
   3. Tanaka M,
   4. Kondo S, et al

   . Clinical significance of reduced cerebral metabolism in multiple sclerosis: a combined PET and MRI study. Ann Nucl Med 1998;12:89–94 doi:10.1007/BF03164835 pmid:9637279

   CrossRefPubMed
4. 4.↵
   2. Bodini B,
   3. Khaleeli Z,
   4. Cercignani M, et al

   . Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: an in vivo study with TBSS and VBM. Hum Brain Map 2009;30:2852–61 doi:10.1002/hbm.20713 pmid:19172648

   CrossRefPubMedWeb of Science
5. 5.↵
   2. Jehna M,
   3. Langkammer C,
   4. Khalil M, et al

   . An exploratory study on the spatial relationship between regional cortical volume changes and white matter integrity in multiple sclerosis. Brain Connect 2013;3:255–64 doi:10.1089/brain.2012.0108 pmid:23573900

   CrossRefPubMed
6. 6.↵
   2. Calabrese M,
   3. Gallo P

   . Magnetic resonance evidence of cortical onset of multiple sclerosis. Mult Scler 2009;15:933–41 doi:10.1177/1352458509106510 pmid:19667021

   CrossRefPubMed
7. 7.↵
   2. Fisher E,
   3. Lee JC,
   4. Nakamura K, et al

   . Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann Neurol 2008;64:255–65 doi:10.1002/ana.21436 pmid:18661561

   CrossRefPubMedWeb of Science
8. 8.↵
   2. Louapre C,
   3. Govindarajan ST,
   4. Gianni C, et al

   . Is the relationship between cortical and white matter pathologic changes in multiple sclerosis spatially specific? A multimodal 7-T and 3-T MR imaging study with surface and tract-based analysis. Radiology 2016;278:524–35 doi:10.1016/j.nicl.2016.11.001 pmid:26334679

   CrossRefPubMed
9. 9.↵
   2. Steenwijk MD,
   3. Daams M,
   4. Pouwels PJ, et al

   . Unraveling the relationship between regional gray matter atrophy and pathology in connected white matter tracts in long-standing multiple sclerosis. Hum Brain Map 2015;36:1796–807 doi:10.1002/hbm.22738 pmid:25627545

   CrossRefPubMed
10. 10.↵
    2. Mainero C,
    3. Louapre C,
    4. Govindarajan ST, et al

    . A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging. Brain 2015;138:932–45 doi:10.1093/brain/awv011 pmid:25681411

    CrossRefPubMed
11. 11.↵
    2. Klaver R,
    3. De Vries HE,
    4. Schenk GJ, et al

    . Grey matter damage in multiple sclerosis: a pathology perspective. Prion 2013;7:66–75 doi:10.4161/pri.2349 pmid:23324595

    CrossRefPubMed
12. 12.↵
    2. Aviv RI,
    3. Francis PL,
    4. Tenenbein R, et al

    . Decreased frontal lobe gray matter perfusion in cognitively impaired patients with secondary-progressive multiple sclerosis detected by the bookend technique. AJNR Am J Neuroradiol 2012;33:1779–85 doi:10.3174/ajnr.A3060 pmid:22538071

    Abstract/FREE Full Text
13. 13.↵
    2. Peruzzo D,
    3. Castellaro M,
    4. Calabrese M, et al

    . Heterogeneity of cortical lesions in multiple sclerosis: an MRI perfusion study. J Cereb Blood Flow Metab 2013;33:457–63 doi:10.1038/jcbfm.2012.192 pmid:23250108

    CrossRefPubMed
14. 14.↵
    2. Debernard L,
    3. Melzer TR,
    4. Van Stockum S, et al

    . Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2014;85:544–51 doi:10.1136/jnnp-2013-305612 pmid:24039024

    Abstract/FREE Full Text
15. 15.↵
    2. Hojjat SP,
    3. Cantrell CG,
    4. Vitorino R, et al

    . Regional reduction in cortical blood flow among cognitively impaired adults with relapsing-remitting multiple sclerosis patients. Mult Scler 2016;11:1421–28 doi:10.1177/1352458515622696 pmid:26754799

    CrossRefPubMed
16. 16.↵
    2. Hojjat SP,
    3. Cantrell CG,
    4. Carroll TJ, et al

    . Perfusion reduction in the absence of structural differences in cognitively impaired versus unimpaired RRMS patients. Mult Scler 2016;22:1685–94 doi:10.1177/1352458516628656 pmid:26846987

    CrossRefPubMed
17. 17.↵
    2. Vakil P,
    3. Lee JJ,
    4. Mouannes-Srour JJ, et al

    . Cerebrovascular occlusive disease: quantitative cerebral blood flow using dynamic susceptibility contrast MR imaging correlates with quantitative H2[150] PET. Radiology 2013;266:879–86 doi:10.1148/radiol.12120756 pmid:23297337

    CrossRefPubMed
18. 18.↵
    2. Shah MK,
    3. Shin W,
    4. Parikh VS, et al

    . Quantitative MR perfusion imaging: preliminary results in stroke. J Magn Reson Imaging 2010;32:796–802 doi:10.1002/jmri.22302 pmid:20882609

    CrossRefPubMed
19. 19.↵
    2. Popescu BF,
    3. Lucchinetti CF

    . Meningeal and cortical grey matter pathology in multiple sclerosis. BMC Neurol 2012;12:1l1 doi:10.1186/1471-2377-12-11 pmid:22397318

    CrossRefPubMed
20. 20.↵
    2. Bö L,
    3. Geurts JJ,
    4. van der Valk P, et al

    . Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis. Arch Neurol 2007;64:76–80 doi:10.1001/archneur.64.1.76 pmid:17210812

    CrossRefPubMedWeb of Science
21. 21.↵
    2. Sethi V,
    3. Yousry T,
    4. Muhlert N, et al

    . A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis. J Neurol Neurosurg Psychiatry 2016;87:750–53 doi:10.1136/jnnp-2015-311102 pmid:26272028

    Abstract/FREE Full Text
22. 22.↵
    2. Francis PL,
    3. Jakubovic R,
    4. O'Connor P, et al

    . Robust perfusion deficits in cognitively impaired patients with secondary-progressive multiple sclerosis. AJNR Am J Neuroradiol 2013;34:62–67 doi:10.3174/ajnr.A3148 pmid:22700746

    Abstract/FREE Full Text
23. 23.↵
    2. Trapp BD,
    3. Peterson J,
    4. Ransohoff RM, et al

    . Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998;338:278–85 doi:10.1056/NEJM199801293380502 pmid:9445407

    CrossRefPubMedWeb of Science
24. 24.↵
    2. Francis PL,
    3. Chia TL,
    4. Jakubovic R, et al

    . Extensive white matter dysfunction in cognitively impaired patients with secondary-progressive multiple sclerosis. AJNR Am J Neuroradiol 2014;35:1910–15 doi:10.3174/ajnr.A3974 pmid:24831599

    Abstract/FREE Full Text
25. 25.↵
    2. Pareto D,
    3. Sastre-Garriga J,
    4. Auger C, et al

    . Juxtacortical lesions and cortical thinning in multiple sclerosis. AJNR Am J Neuroradiol 2015;36:2270–76 doi:10.3174/ajnr.A4485 pmid:26450537

    Abstract/FREE Full Text
26. 26.↵
    2. Gläscher J,
    3. Rudrauf D,
    4. Colom R, et al

    . Distributed neural system for general intelligence revealed by lesion mapping. Proc Natl Acad Sci U S A 2010;107:4705–09 doi:10.1073/pnas.0910397107 pmid:20176936

    Abstract/FREE Full Text