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Research ArticleINTERVENTIONAL
Open Access

Effect of Retrievable Stent Size on Endovascular Treatment of Acute Ischemic Stroke: A Multicenter Study

D. Yang, Y. Hao, W. Zi, H. Wang, D. Zheng, H. Li, M. Tu, Y. Wan, P. Jin, G. Xiao, Y. Xiong, G. Xu and X. Liu
American Journal of Neuroradiology August 2017, 38 (8) 1586-1593; DOI: https://doi.org/10.3174/ajnr.A5232
D. Yang
aFrom the Department of Neurology (D.Y., H.W., X.L.), Jinling Hospital, Second Military Medical University, Nanjing, Jiangsu Province, China
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Y. Hao
bDepartment of Neurology (Y.H., G.Xu, X.L.), Jinling Hospital, Southern Medical University, Nanjing, Jiangsu Province, China
dDepartment of Emergency Medicine (Y.H.), First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
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W. Zi
cDepartment of Neurology (W.Z., Y.X., G.Xu, X.L.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China
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H. Wang
aFrom the Department of Neurology (D.Y., H.W., X.L.), Jinling Hospital, Second Military Medical University, Nanjing, Jiangsu Province, China
eDepartment of Neurology (H.W.), 89th Hospital of the People's Liberation Army, Weifang, Shandong Province, China
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D. Zheng
fDepartment of Neurology (D.Z.), 175th Hospital of the People's Liberation Army, Affiliated Southeast Hospital of Xiamen University, Zhangzhou, Fujian Province, China
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H. Li
gDepartment of Neurology (H.L.), 476th Hospital of the People's Liberation Army, Fuzhou, Fujian Province, China
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M. Tu
hDepartment of Neurology (M.T.), Hubei Wuchang Hospital, Wuhan, Hubei Province, China
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Y. Wan
iDepartment of Neurology (Y.W.), Hubei Zhongshan Hospital, Wuhan, Hubei Province, China
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P. Jin
jDepartment of Neurology (P.J.), Lu'an Affiliated Hospital of Anhui Medical University, Lu'an, Anhui Province, China
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G. Xiao
kDepartment of Neurology (G.Xiao), Second Affiliated Hospital of Soochow University; Suzhou, Jiangsu Province, China.
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Y. Xiong
cDepartment of Neurology (W.Z., Y.X., G.Xu, X.L.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China
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G. Xu
bDepartment of Neurology (Y.H., G.Xu, X.L.), Jinling Hospital, Southern Medical University, Nanjing, Jiangsu Province, China
cDepartment of Neurology (W.Z., Y.X., G.Xu, X.L.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China
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X. Liu
aFrom the Department of Neurology (D.Y., H.W., X.L.), Jinling Hospital, Second Military Medical University, Nanjing, Jiangsu Province, China
bDepartment of Neurology (Y.H., G.Xu, X.L.), Jinling Hospital, Southern Medical University, Nanjing, Jiangsu Province, China
cDepartment of Neurology (W.Z., Y.X., G.Xu, X.L.), Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China
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    Fig 1.

    A 72-year-old male patient who presented with weakness of the left limb for 4 hours. A, CT on admission does not show a large-territory infarct. B, CTA shows right MCA segment occlusion (arrow). C, DSA confirms occlusion of the right MCA segment (arrow). D, A microguidewire crosses the occluded artery. E, A microcatheter crosses the thrombus to the distal segment through the microguidewire. F, Angiogram after deployment of the Solitaire 6 × 30 mm stent retriever shows restoration immediately in the MCA. Arrows show proximal and distal markers of the Solitaire device. G, The stent retriever is unsheathed with the microcatheter being pulled back simultaneously (arrow). H, After 3 passes of thrombectomy, the final angiography shows a mTICI flow of grade 2B in the right MCA with favorable perfusion (arrow). I, CT postprocedure at 24 hours shows no obvious intracerebral hemorrhage. J, MRA postprocedure at 7 days shows good recanalization (arrow).

Tables

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    • View popup
    Table 1:

    Baseline characteristics before and after matchinga

    Before MatchingPAfter MatchingP
    ST 6 (n = 256)ST 4 (n = 372)ST 6 (n = 169)ST 4 (n = 169)
    Age (median) (IQR) (yr)68 (58–75)64 (53–73).00367 (56–75)64 (53–73).103
    Women (No.) (%)112 (43.8%)150 (40.3%).39271 (42%)64 (37.9%).505
    AF (No.) (%)131 (51.2%)138 (37.2%).00180 (47.3%)67 (39.6%).160
    Hypertension (No.) (%)158 (61.7%)231 (62.1%).924112 (66.3%)105 (62.1%).500
    Diabetes mellitus (No.) (%)45 (17.6%)66 (17.7%).95835 (20.7%)29 (17.2%).488
    Current smoker (No.) (%)69 (27%)92 (24.7%).53149 (29%)41 (24.3%).389
    SBP (median) (IQR) (mm Hg)145 (130–161)144 (130–160).537148 (129–163)148 (130–160).393
    GLU (median) (IQR) (mmol/L)6.9 (5.83–8.9)6.7 (5.77–8.38).1736.83 (5.6–9.25)6.9 (5.81–8.69)1.000
    ASPECTS (median) (IQR)9 (7–10)9 (8–10).0019 (7–10)9 (8–10).784
    NIHSS (median) (IQR)17 (13–21)16 (12–20).02917 (13–21)17 (13–21)1.000
    IV (No.) (%)81 (31.6%)119 (32%).92756 (33.1%)61 (36.1%).657
    Time from onset to visit (median) (IQR) (min)130 (75–230)120 (60–214).058138 (64–224)120 (58–214).316
    Time from onset to puncture (median) (IQR) (min)280 (210–350)270 (205–347).692279 (202–345)270 (195–346).589
    Stroke subtype
        Atherosclerotic (No.) (%)95 (37.1%)171 (46%).02768 (40.2%)73 (43.2%).644
        Cardiac embolism (No.) (%)146 (57%)177 (47.5%).0290 (53.3%)85 (50.3%).657
        Undetermined etiology (No.) (%)15 (5.9%)24 (6.5%).76311 (6.5%)11 (6.5%)1.000
    Artery occlusion site
        ICA (No.) (%)155 (60.5%)86 (23.1%)<.00178 (46.2%)76 (45%).791
        MCA (No.) (%)100 (39.1%)284 (76.3%)<.00190 (53.3%)93 (55%).607
        ACA (No.) (%)1 (0.4%)2 (0.5%)1.0001 (0.6%)01.000
    Collateral flow grade (ASITN/SIR)<.001.261
        0–1 (No.) (%)156 (61.2%)156 (42.2%)93 (55%)83 (49.1%)
        2–3 (No.) (%)99 (38.8%)214 (57.8%)76 (45%)86 (50.9%)
    • Note:—ASITN/SIR indicates American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology; AF, atrial fibrillation; GLU, glucose; ACA, anterior cerebral artery; SBP, systolic blood pressure.

    • ↵a The logistic regression model used for the determination of the propensity score included the following factors: age, sex, atrial fibrillation, hypertension, diabetes, time from onset to groin puncture, NIHSS score, ASPECTS, stroke subtype, site of vessel occlusion, and collateral blood flow.

    • View popup
    Table 2:

    Clinical outcomes before and after matching

    Before MatchingPAfter MatchingP
    ST 6 (n = 256)ST 4 (n = 372)ST 6 (n = 169)ST 4 (n = 169)
    mTICI.013.532
        0–2a (No.) (%)51 (19.9%)47 (12.6%)31 (18.3%)26 (15.4%)
        2b–3 (No.) (%)205 (80.1%)325 (87.4%)138 (81.7%)143 (84.6%)
    Workflow time
        Time from puncture to reperfusion (median) (IQR) (min)111.5 (80–153)97 (72–140).007108 (75–147)100 (75–156)1.000
        Time from stent deployment to reperfusion (median) (IQR) (min)61 (30–94)44 (20–75)<.00158 (30–87)45 (21–82).021
        Passes (median) (IQR)2 (1–3)2 (1–3).0012 (1–3)2 (1–3).375
            ≤3 (No.) (%)210 (82%)323 (86.8%).099106 (62.7%)119 (70.4%).154
        Rescue therapy (No.) (%)134 (52.3%)184 (49.5%).47885 (50.3%)84 (49.7%)1.000
    Complications
        Vessel dissection (No.) (%)3 (1.2%)6 (1.6%).7442 (1.2%)5 (3.0%).453
        Arterial perforation (No.) (%)2 (0.8%)6 (1.6%).4822 (1.2%)2 (1.2%)1.000
        Stent failure to deploy (No.) (%)1 (0.4%)0.4081 (0.6%)01.000
        Isolated SAH (No.) (%)4 (1.6%)9 (2.4%).4593 (1.8%)1 (0.6%).625
        Symptomatic ICH (No.) (%)41 (16%)60 (16.1%).97022 (13%)27 (16%).511
        Asymptomatic ICH (No.) (%)92 (35.9%)118 (31.7%).27156 (33.1%)67 (39.6%).248
    mRS 90 days.003.087
        0–2 (No.) (%)89 (34.8%)173 (46.5%)64 (37.9%)79 (46.7%)
        3–6 (No.) (%)167 (65.2%)199 (53.5%)105 (62.1%)90 (53.3%)
        In-hospital mortality (No.) (%)74 (28.9%)78 (21%).02238 (22.5%)39 (23.1%)1.000
    • Note:—ICH indicates intracerebral hemorrhage.

    • View popup
    Table 3:

    Baseline characteristics of atherosclerotic-related occlusion before and after matchinga

    Before MatchingPAfter MatchingP
    ST 6 (n = 95)ST 4 (n = 171)ST 6 (n = 66)ST 4 (n = 66)
    Age (mean) (SD) (yr)65 (11)63 (13).08664 (11.4)62 (11.7).249
    Women (No.) (%)28 (29.5%)47 (27.5%).73016 (24.2%)16 (24.2%)1.000
    Hypertension (No.) (%)65 (68.4%)115 (67.3%).84548 (72.7%)42 (63.6%).307
    Diabetes mellitus (No.) (%)21 (22.1%)30 (17.5%).36516 (24.2%)7 (10.6%).078
    Current smoker (No.) (%)34 (35.8%)56 (32.7%).61525 (37.9%)25 (37.9%)1.000
    SBP (median) (IQR) (mm Hg)148 (135–163)147 (130–160).351148 (135–162)140 (129–160).268
    GLU (median) (IQR) (mmol/L)6.54 (5.46–9.00)6.70 (5.68–8.32).8126.41 (5.2–8.95)6.62 (5.7–8.34).538
    ASPECTS (median) (IQR)9 (7–10)9 (8–10).0129 (8–10)10 (8–10).233
    NIHSS (median) (IQR)16 (12–20)16 (11–19).15416 (12–19)16 (11–19).873
    IV (No.) (%)30 (31.6%)61 (35.7%).50025 (37.9%)24 (36.4%)1.000
    Time from onset to visit (median) (IQR) (min)153 (90–232)120 (60–216).032152 (90–220)122 (49–242).450
    Time from onset to treatment (median) (IQR) (min)293 (225–364)280 (210–356).352289 (224–351)275 (206–355).532
    Artery occlusion site
        ICA (No.) (%)55 (57.9%)33 (19.3%)<.00132 (48.5%)29 (43.9%).375
        MCA (No.) (%)39 (41.1%)136 (79.5%)<.00133 (50%)36 (54.5%).375
        ACA (No.) (%)1 (1.1%)2 (1.2%).9311 (1.5%)1 (1.5%)1.000
    Collateral flow grade (ASITN/SIR).0231.000
        0–1 (No.) (%)50 (52.6%)65 (38.2%)32 (48.5%)31 (47%)
        2–3 (No.) (%)45 (47.4%)105 (61.8%)99 (51.5%)214 (53%)
    • Note:—ASITN/SIR indicates American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology; GLU, glucose; ACA, anterior cerebral artery; SBP, systolic blood pressure.

    • ↵a The logistic regression model used for the determination of the propensity score included the following factors: age, time from onset symptom to visit, time from onset to groin puncture, NIHSS score, ASPECTS, site of vessel occlusion, and collateral blood flow.

    • View popup
    Table 4:

    Clinical outcomes of atherosclerotic-related occlusion before and after matching

    Before MatchingPAfter MatchingP
    ST 6 (n = 95)ST 4 (n = 171)ST 6 (n = 66)ST 4 (n = 66)
    mTICI.012.021
        0–2a (No.) (%)20 (21.1%)17 (9.9%)16 (24.2%)6 (9.1%)
        2b–3 (No.) (%)75 (78.9%)154 (90.1%)50 (75.8%)60 (90.9%)
    Workflow time
        Time from puncture to reperfusion (median) (IQR) (min)125 (90–180)103 (75–145).001120 (89–170)95 (65–136).013
        Time from stent deployment to reperfusion (median) (IQR) (min)69 (32–117)45 (23.5–79).00167 (33–114)46 (19–68).002
        Passes (median) (IQR)2 (1–3)2 (1–2).0422 (1–3)1 (1–2).025
            ≤3 (No.) (%)75 (78.9%)151 (88.3%).04151 (77.3%)60 (90.9%).064
        Rescue therapy (No.) (%)68 (71.6%)99 (57.9%).02747 (71.2%)38 (57.6%).164
    Complications
        Arterial perforation (No.) (%)04 (2.3%).30002 (3.0%).500
        Vessel dissection (No.) (%)1 (1.1%)2 (1.2%)1.00002 (3.0%).500
        Stent failure to deploy (No.) (%)1 (1.1%)0.3571 (1.5%)01.000
        Isolated SAH (No.) (%)06 (3.5%).09201 (1.5%)1.000
        Symptomatic ICH (No.) (%)13 (13.7%)18 (10.5%).4426 (9.1%)4 (6.1%).754
        Asymptomatic ICH (No.) (%)29 (30.5%)52 (30.4%).98419 (28.8%)24 (36.4%).405
    mRS 90 days.032.486
        0–2 (No.) (%)37 (38.9%)90 (52.6%)28 (42.4%)33 (50%)
        3–6 (No.) (%)58 (61.1%)81 (47.4%)38 (57.6%)33 (50%)
        In-hospital mortality (No.) (%)19 (20%)29 (17%).53713 (19.7%)15 (22.7%).832
    • Note:—ICH indicates intracerebral hemorrhage.

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D. Yang, Y. Hao, W. Zi, H. Wang, D. Zheng, H. Li, M. Tu, Y. Wan, P. Jin, G. Xiao, Y. Xiong, G. Xu, X. Liu
Effect of Retrievable Stent Size on Endovascular Treatment of Acute Ischemic Stroke: A Multicenter Study
American Journal of Neuroradiology Aug 2017, 38 (8) 1586-1593; DOI: 10.3174/ajnr.A5232

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Effect of Retrievable Stent Size on Endovascular Treatment of Acute Ischemic Stroke: A Multicenter Study
D. Yang, Y. Hao, W. Zi, H. Wang, D. Zheng, H. Li, M. Tu, Y. Wan, P. Jin, G. Xiao, Y. Xiong, G. Xu, X. Liu
American Journal of Neuroradiology Aug 2017, 38 (8) 1586-1593; DOI: 10.3174/ajnr.A5232
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