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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience

M. Garcia, T.W. Okell, M. Gloor, M.A. Chappell, P. Jezzard, O. Bieri and J.V. Byrne
American Journal of Neuroradiology April 2017, 38 (4) 735-739; DOI: https://doi.org/10.3174/ajnr.A5091
M. Garcia
aFrom the Division of Diagnostic and Interventional Neuroradiology (M. Garcia)
cNuffield Department of Surgical Sciences and Department of Neuroradiology (M. Garcia, J.V.B.)
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T.W. Okell
dCentre for Functional Magnetic Resonance Imaging of the Brain (FMRIB Centre) (T.W.O., M.A.C., P.J.), Nuffield Department of Neurosciences
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M. Gloor
bDivision of Radiological Physics (M. Gloor, O.B.), Department of Radiology Clinic for Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland
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M.A. Chappell
dCentre for Functional Magnetic Resonance Imaging of the Brain (FMRIB Centre) (T.W.O., M.A.C., P.J.), Nuffield Department of Neurosciences
eInstitute of Biomedical Engineering (M.A.C.), Department of Engineering, University of Oxford, Oxford, United Kingdom.
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P. Jezzard
dCentre for Functional Magnetic Resonance Imaging of the Brain (FMRIB Centre) (T.W.O., M.A.C., P.J.), Nuffield Department of Neurosciences
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O. Bieri
bDivision of Radiological Physics (M. Gloor, O.B.), Department of Radiology Clinic for Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland
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J.V. Byrne
cNuffield Department of Surgical Sciences and Department of Neuroradiology (M. Garcia, J.V.B.)
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    Fig 1.

    Examples of the different WM (pn1/pn2, vic1/vic2, rem1/rem2) and GM masks (put, thal) selected on the T1WI contrast-enhanced sequence. Each mask has been labeled in either of the 2 hemispheres. The set of masks was loaded on each perfusion map separately, which had previously been coregistered to the T1WI contrast-enhanced dataset. Except for some of the GM masks, almost all masks were drawn as a volume, which explains their delineation on several consecutive sections. Note the different color for the respective mask in the contralateral hemisphere, because the software did not allow the use of the same color for the respective opposite mask. pn indicates perinidal; vic, vicinity; rem, remote; thal, thalamus; put, putamen.

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    Fig 2.

    When superimposing the red mask representing the ipsilateral pn1 ROI previously drawn in the T1WI contrast-enhanced dataset (T1wCE; left) on the FPD-CT perfusion dataset (right), a good overlap without contamination from bAVM tissue could be observed.

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    Fig 3.

    Box-and-whisker plots for patients 1–4. The boxes show the median, lower, and upper quartiles. Outliers are displayed as red crosses. The mean and SD across the pixels of each ROI of patient 5 are represented in green. ref indicates reference.

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    Fig 4.

    Correlations between different parameters for all patients. The squares represent the ratio for a single pair of masks.

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  • Coefficients of variation aggregating all masks, excluding the outlier (pn 1 of patient 3), across all patients

    ModalityCoefficient of Variation
    FPD-CT21.2%
    ASL-CBF11.0%
    ASL-arrival time12.3%
    DSC-rCBF21.3%
    DSC-rCBV17.8%
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American Journal of Neuroradiology: 38 (4)
American Journal of Neuroradiology
Vol. 38, Issue 4
1 Apr 2017
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Cite this article
M. Garcia, T.W. Okell, M. Gloor, M.A. Chappell, P. Jezzard, O. Bieri, J.V. Byrne
Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience
American Journal of Neuroradiology Apr 2017, 38 (4) 735-739; DOI: 10.3174/ajnr.A5091

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Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience
M. Garcia, T.W. Okell, M. Gloor, M.A. Chappell, P. Jezzard, O. Bieri, J.V. Byrne
American Journal of Neuroradiology Apr 2017, 38 (4) 735-739; DOI: 10.3174/ajnr.A5091
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