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Research ArticleAdult Brain
Open Access

Hippocampal and Deep Gray Matter Nuclei Atrophy Is Relevant for Explaining Cognitive Impairment in MS: A Multicenter Study

D. Damjanovic, P. Valsasina, M.A. Rocca, M.L. Stromillo, A. Gallo, C. Enzinger, H.E. Hulst, A. Rovira, N. Muhlert, N. De Stefano, A. Bisecco, F. Fazekas, M.J. Arévalo, T.A. Yousry and M. Filippi
American Journal of Neuroradiology January 2017, 38 (1) 18-24; DOI: https://doi.org/10.3174/ajnr.A4952
D. Damjanovic
aFrom the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.)
cCenter for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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  • ORCID record for D. Damjanovic
P. Valsasina
aFrom the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.)
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  • ORCID record for P. Valsasina
M.A. Rocca
aFrom the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.)
bDepartment of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
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M.L. Stromillo
dDepartment of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy
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A. Gallo
eMRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy
fI Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy
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C. Enzinger
gDepartment of Neurology (C.E., F.F.)
hDivision of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria
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H.E. Hulst
iDepartment of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands
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A. Rovira
jMagnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain
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N. Muhlert
kNMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
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N. De Stefano
dDepartment of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy
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A. Bisecco
eMRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy
fI Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy
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F. Fazekas
gDepartment of Neurology (C.E., F.F.)
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M.J. Arévalo
jMagnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain
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T.A. Yousry
kNMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
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M. Filippi
aFrom the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.)
bDepartment of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
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Article Information

vol. 38 no. 1 18-24
DOI 
https://doi.org/10.3174/ajnr.A4952
PubMed 
27686487

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received June 8, 2016
  • Accepted after revision August 11, 2016
  • Published online January 11, 2017.

Article Versions

  • Latest version (September 29, 2016 - 07:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2017 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. D. Damjanovica,c,
  2. P. Valsasinaa,
  3. M.A. Roccaa,b,
  4. M.L. Stromillod,
  5. A. Galloe,f,
  6. C. Enzingerg,h,
  7. H.E. Hulsti,
  8. A. Roviraj,
  9. N. Muhlertk,
  10. N. De Stefanod,
  11. A. Biseccoe,f,
  12. F. Fazekasg,
  13. M.J. Arévaloj,
  14. T.A. Yousryk and
  15. M. Filippia,b
  1. aFrom the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.)
  2. bDepartment of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
  3. cCenter for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  4. dDepartment of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy
  5. eMRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy
  6. fI Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy
  7. gDepartment of Neurology (C.E., F.F.)
  8. hDivision of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria
  9. iDepartment of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands
  10. jMagnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain
  11. kNMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
  1. Please address correspondence to Massimo Filippi, MD, Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy; e-mail: filippi.massimo{at}hsr.it
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Cite this article
D. Damjanovic, P. Valsasina, M.A. Rocca, M.L. Stromillo, A. Gallo, C. Enzinger, H.E. Hulst, A. Rovira, N. Muhlert, N. De Stefano, A. Bisecco, F. Fazekas, M.J. Arévalo, T.A. Yousry, M. Filippi
Hippocampal and Deep Gray Matter Nuclei Atrophy Is Relevant for Explaining Cognitive Impairment in MS: A Multicenter Study
American Journal of Neuroradiology Jan 2017, 38 (1) 18-24; DOI: 10.3174/ajnr.A4952

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Hippocampal and Deep Gray Matter Nuclei Atrophy Is Relevant for Explaining Cognitive Impairment in MS: A Multicenter Study
D. Damjanovic, P. Valsasina, M.A. Rocca, M.L. Stromillo, A. Gallo, C. Enzinger, H.E. Hulst, A. Rovira, N. Muhlert, N. De Stefano, A. Bisecco, F. Fazekas, M.J. Arévalo, T.A. Yousry, M. Filippi
American Journal of Neuroradiology Jan 2017, 38 (1) 18-24; DOI: 10.3174/ajnr.A4952
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