Tractography at 3T MRI of Corpus Callosum Tracts Crossing White Matter Hyperintensities

W. Reginold; J. Itorralba; A.C. Luedke; J. Fernandez-Ruiz; J. Reginold; O. Islam; A. Garcia

doi:10.3174/ajnr.A4788

Article Figures & Data

Figures

Tables

Download figure
Open in new tab
Download powerpoint
Fig 1.
Tract segmentation, WMH tracts, and lesion-free tracts. Axial T2 FLAIR demonstrates white matter hyperintensities, tractography representation of the entire tracts, WMH tracts, and lesion-free tracts in the corpus callosum (A), cingulum (B), association fibers (C), corticospinal/bulbar tract (D), and thalamic tracts (E).

Tables

Figures

View popup
Table 1:
Demographic and clinical data for participants^{^a}
Total
No. 24
Age (yr) 70.4 ± 9.2
Sex (M/F count) 8/16
WMH volume (voxels) 1190 ± 3030
MoCA 27.7 ± 1.7
Note:—MoCA indicates Montreal Cognitive Assessment.
↵a Values are means and SDs unless otherwise noted.

View popup

Table 2:

Comparison in major white matter tracts of the fractional anisotropy, mean diffusivity, and radial diffusivity of tracts crossing and not crossing WMH^{^a}

	No. of Subjects with Tracts Crossing WMH	Crossing WMH	Not Crossing WMH	P Value
Fractional anisotropy
Corpus callosum	24	0.539 ± 0.057	0.591 ± 0.046	.002^{^b}
Cingulum	17	0.442 ± 0.076	0.448 ± 0.047	.152
Association fibers	21	0.410 ± 0.054	0.424 ± 0.034	.093
Corticospinal tract	20	0.446 ± 0.061	0.477 ± 0.032	.027
Thalamus	16	0.452 ± 0.073	0.441 ± 0.032	.130
Mean diffusivity
Corpus callosum	24	0.00085 ± 0.0001	0.000932 ± 0.0001	.053
Cingulum	17	0.0009 ± 0.0002	0.0008 ± 0.0001	.013
Association fibers	21	0.00079 ± 0.0001	0.00078 ± 0.0001	.122
Corticospinal tract	20	0.0008 ± 0.0001	0.0007 ± 0.0001	.047
Thalamus	16	0.00078 ± 0.0002	0.0008 ± 0.0001	.145
Radial diffusivity
Corpus callosum	24	0.0006 ± 0.0001	0.0006 ± 0.0001	.140
Cingulum	17	0.0007 ± 0.0002	0.0006 ± 0.0001	.001^{^b}
Association fibers	21	0.0006 ± 0.0001	0.0006 ± 0.0001	.143
Corticospinal tract	20	0.0006 ± 0.0001	0.0005 ± 0.0001	.070
Thalamus	16	0.0007 ± 0.0002	0.0006 ± 0.0001	.126