Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Relationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers

J.I. Berman, D. Chudnovskaya, L. Blaskey, E. Kuschner, P. Mukherjee, R. Buckner, S. Nagarajan, W.K. Chung, E.H. Sherr and T.P.L. Roberts
American Journal of Neuroradiology June 2016, 37 (6) 1178-1184; DOI: https://doi.org/10.3174/ajnr.A4687
J.I. Berman
aFrom the Department of Radiology (J.I.B., D.C., L.B., E.K., T.P.L.R.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
bDepartment of Radiology (J.I.B., T.P.L.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.I. Berman
D. Chudnovskaya
aFrom the Department of Radiology (J.I.B., D.C., L.B., E.K., T.P.L.R.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Chudnovskaya
L. Blaskey
aFrom the Department of Radiology (J.I.B., D.C., L.B., E.K., T.P.L.R.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L. Blaskey
E. Kuschner
aFrom the Department of Radiology (J.I.B., D.C., L.B., E.K., T.P.L.R.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Kuschner
P. Mukherjee
cDepartments of Radiology (P.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Mukherjee
R. Buckner
eDepartment of Psychology (R.B.), Harvard University, Cambridge, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Buckner
S. Nagarajan
fDepartments of Pediatrics and Medicine (S.N., W.K.C.), Columbia University Medical Center, New York, New York.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Nagarajan
W.K. Chung
fDepartments of Pediatrics and Medicine (S.N., W.K.C.), Columbia University Medical Center, New York, New York.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W.K. Chung
E.H. Sherr
dNeurology (E.H.S.), University of California, San Francisco School of Medicine, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E.H. Sherr
T.P.L. Roberts
aFrom the Department of Radiology (J.I.B., D.C., L.B., E.K., T.P.L.R.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
bDepartment of Radiology (J.I.B., T.P.L.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T.P.L. Roberts
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    The Simons VIP Consortium. Simons Variation in Individuals Project (Simons VIP): a genetics-first approach to studying autism spectrum and related neurodevelopmental disorders. Neuron 2012;73:1063–67 doi:10.1016/j.neuron.2012.02.014 pmid:22445335
    CrossRefPubMed
  2. 2.↵
    1. Weiss LA,
    2. Shen Y,
    3. Korn JM, et al
    . Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med 2008;358:667–75 doi:10.1056/NEJMoa075974 pmid:18184952
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Bochukova EG,
    2. Huang N,
    3. Keogh J, et al
    . Large, rare chromosomal deletions associated with severe early-onset obesity. Nature 2010;463:666–70 doi:10.1038/nature08689 pmid:19966786
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Jacquemont S,
    2. Reymond A,
    3. Zufferey F, et al
    . Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature 2011;478:97–102 doi:10.1038/nature10406 pmid:21881559
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Fernandez BA,
    2. Roberts W,
    3. Chung B, et al
    . Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of autism spectrum disorder. J Med Genet 2010;47:195–203 doi:10.1136/jmg.2009.069369 pmid:19755429
    Abstract/FREE Full Text
  6. 6.↵
    1. Rosenfeld JA,
    2. Coppinger J,
    3. Bejjani BA, et al
    . Speech delays and behavioral problems are the predominant features in individuals with developmental delays and 16p11.2 microdeletions and microduplications. J Neurodev Disord 2010;2:26–38 doi:10.1007/s11689-009-9037-4 pmid:21731881
    CrossRefPubMed
  7. 7.↵
    1. Hanson E,
    2. Bernier R,
    3. Porche K, et al
    ; Simons Variation in Individuals Project Consortium. The cognitive and behavioral phenotype of the 16p11.2 deletion in a clinically ascertained population. Biol Psychiatry 2015;77:785–93 doi:10.1016/j.biopsych.2014.04.021 pmid:25064419
    CrossRefPubMed
  8. 8.↵
    1. Zufferey F,
    2. Sherr EH,
    3. Beckmann ND, et al
    ; Simons VIP Consortium, 16p11.2 European Consortium. A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders. J Med Genet 2012;49:660–68 doi:10.1136/jmedgenet-2012-101203 pmid:23054248
    Abstract/FREE Full Text
  9. 9.↵
    1. Hanson E,
    2. Nasir RH,
    3. Fong A, et al
    ; 16p11.2 Study Group Clinicians. Cognitive and behavioral characterization of 16p11.2 deletion syndrome. J Dev Behav Pediatr 2010;31:649–57 doi:10.1097/DBP.0b013e3181ea50ed pmid:20613623
    CrossRefPubMed
  10. 10.↵
    1. Qureshi AY,
    2. Mueller S,
    3. Snyder AZ, et al
    ; Simons VIP Consortium. Opposing brain differences in 16p11.2 deletion and duplication carriers. J Neurosci 2014;34:11199–211 doi:10.1523/JNEUROSCI.1366-14.2014 pmid:25143601
    Abstract/FREE Full Text
  11. 11.↵
    1. Owen JP,
    2. Chang YS,
    3. Pojman NJ, et al
    ; Simons VIP Consortium. Aberrant white matter microstructure in children with 16p11.2 deletions. J Neurosci 2014;34:6214–23 doi:10.1523/JNEUROSCI.4495-13.2014 pmid:24790192
    Abstract/FREE Full Text
  12. 12.↵
    1. Berman JI,
    2. Chudnovskaya D,
    3. Blaskey L, et al
    . Abnormal auditory and language pathways in children with 16p11.2 deletion. Neuroimage Clin 2015;9:50–57 doi:10.1016/j.nicl.2015.07.006 pmid:26413471
    CrossRefPubMed
  13. 13.↵
    1. Jenkins J,
    2. Chow V,
    3. Blaskey L, et al
    . Auditory evoked M100 response latency is delayed in children with 16p11.2 deletion but not 16p11.2 duplication. Cereb Cortex 2015 Feb 11. [Epub ahead of print] doi:10.1093/cercor/bhv008 pmid:25678630
    Abstract/FREE Full Text
  14. 14.↵
    1. Roberts TP,
    2. Lanza MR,
    3. Dell J, et al
    . Maturational differences in thalamocortical white matter microstructure and auditory evoked response latencies in autism spectrum disorders. Brain Res 2013;1537:79–85 doi:10.1016/j.brainres.2013.09.011 pmid:24055954
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Lange N,
    2. DuBray MB,
    3. Lee JE, et al
    . Atypical diffusion tensor hemispheric asymmetry in autism. Autism Res 2010;3:350–58 doi:10.1002/aur.162 pmid:21182212
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Berman J,
    2. Lanza M,
    3. Blaskey L, et al
    . High angular resolution diffusion imaging probabilistic tractography of the auditory radiation. AJNR Am J Neuroradiol 2013;34:1573–78 doi:10.3174/ajnr.A3471 pmid:23493892
    Abstract/FREE Full Text
  17. 17.↵
    1. Semel EM,
    2. Wiig EH,
    3. Secord W
    . Clinical Evaluation of Language Fundamentals (CELF-4). San Antonio: The Psychological Corporation; 2003
  18. 18.↵
    1. Elliott CD
    . Differential Ability Scales. 2nd ed. San Antonio: Pearson; 2007
  19. 19.↵
    1. Lord C,
    2. Risi S,
    3. Lambrecht L, et al
    . The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 2000;30:205–23 doi:10.1023/A:1005592401947 pmid:11055457
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Rutter M,
    2. Bailey A,
    3. Lord C
    . Social Communication Questionnaire (SCQ). Los Angeles: Western Psychological Services; 2003
  21. 21.↵
    1. Owen JP,
    2. Ziv E,
    3. Bukshpun P, et al
    . Test-retest reliability of computational network measurements derived from the structural connectome of the human brain. Brain Connect 2013;3:160–76 doi:10.1089/brain.2012.0121 pmid:23350832
    CrossRefPubMed
  22. 22.↵
    1. van der Kouwe AJ,
    2. Benner T,
    3. Salat DH, et al
    . Brain morphometry with multiecho MPRAGE. Neuroimage 2008;40:559–69 doi:10.1016/j.neuroimage.2007.12.025 pmid:18242102
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Berman JI,
    2. Chung S,
    3. Mukherjee P, et al
    . Probabilistic streamline q-ball tractography using the residual bootstrap. Neuroimage 2008;39:215–22 doi:10.1016/j.neuroimage.2007.08.021 pmid:17911030
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Fischl B,
    2. Sereno MI,
    3. Tootell RB, et al
    . High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp 1999;8:272–84 pmid:10619420
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Roberts TP,
    2. Ferrari P,
    3. Stufflebeam SM, et al
    . Latency of the auditory evoked neuromagnetic field components: stimulus dependence and insights toward perception. J Clin Neurophysiol 2000;17:114–29 doi:10.1097/00004691-200003000-00002 pmid:10831104
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Taschenberger H,
    2. von Gersdorff H
    . Fine-tuning an auditory synapse for speed and fidelity: developmental changes in presynaptic waveform, EPSC kinetics, and synaptic plasticity. J Neurosci 2000;20:9162–73 pmid:11124994
    Abstract/FREE Full Text
  27. 27.↵
    1. Gaetz W,
    2. Bloy L,
    3. Wang DJ, et al
    . GABA estimation in the brains of children on the autism spectrum: measurement precision and regional cortical variation. Neuroimage 2014;86:1–9 doi:10.1016/j.neuroimage.2013.05.068 pmid:23707581
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Canolty RT,
    2. Knight RT
    . The functional role of cross-frequency coupling. Trends Cogn Sci 2010;14:506–15 doi:10.1016/j.tics.2010.09.001 pmid:20932795
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Aggarwal M,
    2. Nauen DW,
    3. Troncoso JC, et al
    . Probing region-specific microstructure of human cortical areas using high angular and spatial resolution diffusion MRI. Neuroimage 2015;105:198–207 doi:10.1016/j.neuroimage.2014.10.053 pmid:25449747
    CrossRefPubMed
  30. 30.↵
    1. Roberts TP,
    2. Khan SY,
    3. Blaskey L, et al
    . Developmental correlation of diffusion anisotropy with auditory-evoked response. Neuroreport 2009;20:1586–91 doi:10.1097/WNR.0b013e3283306854 pmid:19898261
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 37 (6)
American Journal of Neuroradiology
Vol. 37, Issue 6
1 Jun 2016
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Relationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
J.I. Berman, D. Chudnovskaya, L. Blaskey, E. Kuschner, P. Mukherjee, R. Buckner, S. Nagarajan, W.K. Chung, E.H. Sherr, T.P.L. Roberts
Relationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers
American Journal of Neuroradiology Jun 2016, 37 (6) 1178-1184; DOI: 10.3174/ajnr.A4687

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Relationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers
J.I. Berman, D. Chudnovskaya, L. Blaskey, E. Kuschner, P. Mukherjee, R. Buckner, S. Nagarajan, W.K. Chung, E.H. Sherr, T.P.L. Roberts
American Journal of Neuroradiology Jun 2016, 37 (6) 1178-1184; DOI: 10.3174/ajnr.A4687
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Health supervision for children and adolescents with 16p11.2 deletion syndrome
  • Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk
  • Sensorimotor Cortical Oscillations during Movement Preparation in 16p11.2 Deletion Carriers
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Frontal Paraventricular Cysts
  • Sodium MRI in Pediatric Brain Tumors
  • FRACTURE MR in Congenital Vertebral Anomalies
Show more Pediatric Neuroimaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire