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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine Imaging and Spine Image-Guided Interventions

Comparison of Sagittal FSE T2, STIR, and T1-Weighted Phase-Sensitive Inversion Recovery in the Detection of Spinal Cord Lesions in MS at 3T

P. Alcaide-Leon, A. Pauranik, L. Alshafai, S. Rawal, J. Oh, W. Montanera, G. Leung and A. Bharatha
American Journal of Neuroradiology May 2016, 37 (5) 970-975; DOI: https://doi.org/10.3174/ajnr.A4656
P. Alcaide-Leon
aFrom the Departments of Medical Imaging (P.A.-L., A.P., W.M., G.L., A.B.)
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A. Pauranik
aFrom the Departments of Medical Imaging (P.A.-L., A.P., W.M., G.L., A.B.)
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L. Alshafai
cDepartment of Medical Imaging (L.A.), University Health Network, Mount Sinai Hospital, Toronto, Ontario, Canada
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S. Rawal
dDepartment of Medical Imaging (S.R.), University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada.
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J. Oh
bMovement Disorders (J.O.), St Michael's Hospital, Toronto, Ontario, Canada
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W. Montanera
aFrom the Departments of Medical Imaging (P.A.-L., A.P., W.M., G.L., A.B.)
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G. Leung
aFrom the Departments of Medical Imaging (P.A.-L., A.P., W.M., G.L., A.B.)
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A. Bharatha
aFrom the Departments of Medical Imaging (P.A.-L., A.P., W.M., G.L., A.B.)
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    Fig 1.

    Sagittal PSIR (A), FSE T2 (B), and STIR (C) sequences in a patient with MS. A demyelinating lesion at the C2 level (arrows) is adequately visualized on PSIR (A) and STIR (C) but not on FSE T2 (B). C, An example of reference lines through the center on the disc spaces used to separate the vertebral levels (gray lines).

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    Fig 2.

    Stacked bar charts show the total number of true-positive, false-negative, and false-positive spinal cord segments in the cervical (A) and thoracic (B) regions on the 3 different sagittal sequences evaluated. The horizontal lines represent the total number of segments truly affected by lesions as per criterion standard evaluation.

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    Fig 3.

    A, Thoracic sagittal PSIR image of a patient with MS with a thick back fat pad shows increased noise and failure of CSF suppression. A demyelinating lesion (white arrow) is clearly identified on STIR (B) but not seen on PSIR (A). Sagittal PSIR (C) and STIR (D) sequences of a slim patient with MS show adequate contrast between the lesions (arrow caps) and the cord and adequate CSF signal suppression on PSIR. E, The boxplot shows the distribution of the variable thickness of the back fat pad in the group of patients with good- and poor-quality thoracic PSIR images. The bottom and the top of the boxes represent the 25th and 75th percentiles, respectively; the median is represented by the horizontal line in the box; and the range corresponds to the whiskers that extend from the box. Patients with poor-quality PSIR sequences of the thoracic spine have a median back fat pad size significantly thicker than that in patients with good-quality images. F, The scatterplot shows the negative correlation between the sensitivity of the PSIR sequence of the thoracic segment and the thickness of the back fat pad (r = −0.53).

Tables

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  • Acquisition parameters of MR imaging sequences

    SegmentSequencePlaneFOV (mm)Acquisition MatrixThickness (mm)TR (ms)TE (ms)TI (ms)No. of Signals AcquiredAcquisition Time (min:sec)Parallel Imaging
    CervicalPSIRSagittal220320 × 224324009.440024:45GRAPPA 2
    CervicalSTIRSagittal300448 × 33634005120015:46GRAPPA 2
    CervicalFSE PDSagittal220320 × 288325002312:02None
    CervicalFSE T2Sagittal220384 × 3073350010623:35None
    CervicalGE T2Transverse180256 × 21837401724:25GRAPPA 2
    ThoracicPSIRSagittal330384 × 269324009.540024:45GRAPPA 2
    ThoracicSTIRSagittal330448 × 336340005020015:46GRAPPA 2
    ThoracicFSE PDSagittal330320 × 288325002114:02None
    ThoracicFSE T2Sagittal330448 × 336340009614:26None
    ThoracicFSE T2Transverse180256 × 1765678010724:46None
    • Note:—GE indicates gradient-echo; PD, proton density; GRAPPA, generalized autocalibrating partially parallel acquisition.

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American Journal of Neuroradiology: 37 (5)
American Journal of Neuroradiology
Vol. 37, Issue 5
1 May 2016
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Cite this article
P. Alcaide-Leon, A. Pauranik, L. Alshafai, S. Rawal, J. Oh, W. Montanera, G. Leung, A. Bharatha
Comparison of Sagittal FSE T2, STIR, and T1-Weighted Phase-Sensitive Inversion Recovery in the Detection of Spinal Cord Lesions in MS at 3T
American Journal of Neuroradiology May 2016, 37 (5) 970-975; DOI: 10.3174/ajnr.A4656

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Comparison of Sagittal FSE T2, STIR, and T1-Weighted Phase-Sensitive Inversion Recovery in the Detection of Spinal Cord Lesions in MS at 3T
P. Alcaide-Leon, A. Pauranik, L. Alshafai, S. Rawal, J. Oh, W. Montanera, G. Leung, A. Bharatha
American Journal of Neuroradiology May 2016, 37 (5) 970-975; DOI: 10.3174/ajnr.A4656
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