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Research ArticleAdult Brain
Open Access

Clinical Applications of Simultaneous PET/MR Imaging Using (R)-[11C]-Verapamil with Cyclosporin A: Preliminary Results on a Surrogate Marker of Drug-Resistant Epilepsy

J.-W. Shin, K. Chu, S.A. Shin, K.-H. Jung, S.-T. Lee, Y.-S. Lee, J. Moon, D.Y. Lee, J.S. Lee, D.S. Lee and S.K. Lee
American Journal of Neuroradiology April 2016, 37 (4) 600-606; DOI: https://doi.org/10.3174/ajnr.A4566
J.-W. Shin
aFrom the Department of Neurology (J.-W.S., K.C., K.-H.J., S.-T.L., J.M., D.Y.L., S.K.L.), Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Biomedical Research Institute
dDepartment of Neurology (J.-W.S.), CHA Bundang Medical Center, CHA University, Seongnam, Korea
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K. Chu
aFrom the Department of Neurology (J.-W.S., K.C., K.-H.J., S.-T.L., J.M., D.Y.L., S.K.L.), Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Biomedical Research Institute
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S.A. Shin
bDepartment of Nuclear Medicine (S.A.S., Y.-S.L., J.S.L., D.S.L.)
cDepartment of Biomedical Sciences (S.A.S., J.S.L.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea
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K.-H. Jung
aFrom the Department of Neurology (J.-W.S., K.C., K.-H.J., S.-T.L., J.M., D.Y.L., S.K.L.), Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Biomedical Research Institute
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S.-T. Lee
aFrom the Department of Neurology (J.-W.S., K.C., K.-H.J., S.-T.L., J.M., D.Y.L., S.K.L.), Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Biomedical Research Institute
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Y.-S. Lee
bDepartment of Nuclear Medicine (S.A.S., Y.-S.L., J.S.L., D.S.L.)
eDepartment of Molecular Medicine and Biopharmaceutical Sciences (Y.-S.L., D.S.L.), Graduate School of Convergence Science and Technology, Kyunggi, South Korea.
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J. Moon
aFrom the Department of Neurology (J.-W.S., K.C., K.-H.J., S.-T.L., J.M., D.Y.L., S.K.L.), Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Biomedical Research Institute
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D.Y. Lee
aFrom the Department of Neurology (J.-W.S., K.C., K.-H.J., S.-T.L., J.M., D.Y.L., S.K.L.), Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Biomedical Research Institute
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J.S. Lee
bDepartment of Nuclear Medicine (S.A.S., Y.-S.L., J.S.L., D.S.L.)
cDepartment of Biomedical Sciences (S.A.S., J.S.L.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea
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D.S. Lee
bDepartment of Nuclear Medicine (S.A.S., Y.-S.L., J.S.L., D.S.L.)
eDepartment of Molecular Medicine and Biopharmaceutical Sciences (Y.-S.L., D.S.L.), Graduate School of Convergence Science and Technology, Kyunggi, South Korea.
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S.K. Lee
aFrom the Department of Neurology (J.-W.S., K.C., K.-H.J., S.-T.L., J.M., D.Y.L., S.K.L.), Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Biomedical Research Institute
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REFERENCES

  1. 1.↵
    1. Browne TR,
    2. Holmes GL
    . Epilepsy. N Engl J Med 2001;344:1145–51 doi:10.1056/NEJM200104123441507 pmid:11297707
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Löscher W,
    2. Schmidt D
    . Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011;52:657–78 doi:10.1111/j.1528-1167.2011.03024.x pmid:21426333
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Sillanpää M,
    2. Schmidt D
    . Natural history of treated childhood-onset epilepsy: prospective, long-term population-based study. Brain 2006;129:617–24 doi:10.1093/brain/awh726 pmid:16401617
    Abstract/FREE Full Text
  4. 4.↵
    1. Löscher W,
    2. Klitgaard H,
    3. Twyman RE, et al
    . New avenues for anti-epileptic drug discovery and development. Nat Rev Drug Discov 2013;12:757–76 doi:10.1038/nrd4126 pmid:24052047
    CrossRefPubMed
  5. 5.↵
    1. Löscher W,
    2. Potschka H
    . Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 2005;6:591–602 doi:10.1038/nrn1728 pmid:16025095
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Potschka H
    . Role of CNS efflux drug transporters in antiepileptic drug delivery: overcoming CNS efflux drug transport. Adv Drug Deliv Rev 2012;64:943–52 doi:10.1016/j.addr.2011.12.007 pmid:22210135
    CrossRefPubMed
  7. 7.↵
    1. Liu JY,
    2. Thom M,
    3. Catarino CB, et al
    . Neuropathology of the blood-brain barrier and pharmaco-resistance in human epilepsy. Brain 2012;135:3115–33 doi:10.1093/brain/aws147 pmid:22750659
    Abstract/FREE Full Text
  8. 8.↵
    1. Muzi M,
    2. Mankoff DA,
    3. Link JM, et al
    . Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans. J Nucl Med 2009;50:1267–75 doi:10.2967/jnumed.108.059162 pmid:19617341
    Abstract/FREE Full Text
  9. 9.↵
    1. Wagner CC,
    2. Bauer M,
    3. Karch R, et al
    . A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET. J Nucl Med 2009;50:1954–61 doi:10.2967/jnumed.109.063289 pmid:19910428
    Abstract/FREE Full Text
  10. 10.↵
    1. Bauer M,
    2. Karch R,
    3. Neumann F, et al
    . Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier. Cereb Blood Flow Metab 2010;30:510–15 doi:10.1038/jcbfm.2009.265 pmid:20010957
    Abstract/FREE Full Text
  11. 11.↵
    1. Dukart J,
    2. Mueller K,
    3. Horstmann A, et al
    . Differential effects of global and cerebellar normalization on detection and differentiation of dementia in FDG-PET studies. Neuroimage 2010;49:1490–95 doi:10.1016/j.neuroimage.2009.09.017 pmid:19770055
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Kwan P,
    2. Arzimanoglou A,
    3. Berg AT, et al
    . Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010;51:1069–77 doi:10.1111/j.1528-1167.2009.02397.x pmid:19889013
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Kang KW,
    2. Lee DS,
    3. Cho JH, et al
    . Quantification of F-18 FDG PET images in temporal lobe epilepsy patients using probabilistic brain atlas. Neuroimage 2001;14:1–6 doi:10.1006/nimg.2001.0783 pmid:11525319
    CrossRefPubMed
  14. 14.↵
    1. Lee JS,
    2. Lee DS
    . Analysis of functional brain images using population-based probabilistic atlas. Current Medical Imaging Reviews 2005;1:81–87 doi:10.2174/1573405052953056
    CrossRef
  15. 15.↵
    1. Kim DW,
    2. Lee SK,
    3. Chu K, et al
    . Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy. Epilepsy Res 2009;84:86–90 doi:10.1016/j.eplepsyres.2008.12.001 pmid:19167193
    CrossRefPubMed
  16. 16.↵
    1. Langer O,
    2. Bauer M,
    3. Hammers A, et al
    . Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia 2007;48:1774–84 doi:10.1111/j.1528-1167.2007.01116.x pmid:17484754
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Feldmann M,
    2. Asselin MC,
    3. Liu J, et al
    . P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study. Lancet Neurol 2013;12:777–85 doi:10.1016/S1474-4422(13)70109-1 pmid:23786896
    CrossRefPubMed
  18. 18.↵
    1. Kalvass JC,
    2. Polli JW,
    3. Bourdet DL, et al
    ; International Transporter Consortium. Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position. Clin Pharmacol Ther 2013;94:80–94 doi:10.1038/clpt.2013.34 pmid:23588303
    CrossRefPubMed
  19. 19.↵
    1. Syvänen S,
    2. Eriksson J
    . Advances in PET imaging of P-glycoprotein function at the blood-brain barrier. ACS Chem Neurosci 2013;4:225–37 doi:10.1021/cn3001729 pmid:23421673
    CrossRefPubMed
  20. 20.↵
    1. Taubert D,
    2. von Beckerath N,
    3. Grimberg G, et al
    . Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther 2006;80:486–501 doi:10.1016/j.clpt.2006.07.007 pmid:17112805
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Syvänen S,
    2. Blomquist G,
    3. Sprycha M, et al
    . Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET. Neuroimage 2006;32:1134–41 doi:10.1016/j.neuroimage.2006.05.047 pmid:16857389
    CrossRefPubMed
  22. 22.↵
    1. Syvänen S,
    2. Hooker A,
    3. Rahman O, et al
    . Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier. J Pharm Sci 2008;97:5386–400 doi:10.1002/jps.21359 pmid:18384156
    CrossRefPubMed
  23. 23.↵
    1. Deo AK,
    2. Borson S,
    3. Link JM, et al
    . Activity of P-glycoprotein, a β-amyloid transporter at the blood-brain barrier, is compromised in patients with mild Alzheimer disease. J Nucl Med 2014;55:1106–11 doi:10.2967/jnumed.113.130161 pmid:24842892
    Abstract/FREE Full Text
  24. 24.↵
    1. Asadi-Pooya AA,
    2. Razavizadegan SM,
    3. Abdi-Ardekani A, et al
    . Adjunctive use of verapamil in patients with refractory temporal lobe epilepsy: a pilot study. Epilepsy Behav 2013;29:150–54 doi:10.1016/j.yebeh.2013.07.006 pmid:23973639
    CrossRefPubMed
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J.-W. Shin, K. Chu, S.A. Shin, K.-H. Jung, S.-T. Lee, Y.-S. Lee, J. Moon, D.Y. Lee, J.S. Lee, D.S. Lee, S.K. Lee
Clinical Applications of Simultaneous PET/MR Imaging Using (R)-[11C]-Verapamil with Cyclosporin A: Preliminary Results on a Surrogate Marker of Drug-Resistant Epilepsy
American Journal of Neuroradiology Apr 2016, 37 (4) 600-606; DOI: 10.3174/ajnr.A4566

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Clinical Applications of Simultaneous PET/MR Imaging Using (R)-[11C]-Verapamil with Cyclosporin A: Preliminary Results on a Surrogate Marker of Drug-Resistant Epilepsy
J.-W. Shin, K. Chu, S.A. Shin, K.-H. Jung, S.-T. Lee, Y.-S. Lee, J. Moon, D.Y. Lee, J.S. Lee, D.S. Lee, S.K. Lee
American Journal of Neuroradiology Apr 2016, 37 (4) 600-606; DOI: 10.3174/ajnr.A4566
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