Article Figures & Data
Figures
- Figure.
Box-and-whisker plots of microvessel area according to histopathologic grade (A) and microvessel density according to histopathologic grade (B). The asterisk indicates P < .05.
Tables
- Table 1:
Median values of MVA, MVD, and DCE- and DSC-MRI parameters with interquartile range for low and high-grade gliomasa
Low-Grade (n = 10) High-Grade (n = 33) P Value MVA (%) 1.4 (0.66–2.09) 3.2 (1.82–9.38) .002 MVD (mm2) 129 (93–202) 376 (157–768) .006 Large-tumor Vp_Φ (%) 0.098 (0.01–0.58) 1.45 (0.71–2.21) .001 Large-tumor Vp_SI (%) 0.69 (0.27–2.20) 3.12 (1.37–6.72) .04 Large-tumor uCBV (a.u.) 35.8 (16.9–62.8) 80.8 (57.3–152.5) .01 Large-tumor rCBV 2.9 (1.53–4.19) 5.43 (3.19–8.21) .02 Large-tumor Ktrans_Φ (min−1) 0.00016 (0.00001–0.00225) 0.019 (0.011–0.041) .002 Large-tumor Ktrans_SI (min−1) 0.0012 (0.0004–0.0137) 0.05 (0.0118–0.0773) .004 Hot spot Vp_Φ (%) 0.46 (0.02–1.04) 2.93 (1.85–4.42) .0004 Hot spot Vp_SI (%) 1.84 (1.13–3.39) 8.51 (4.14–13.80) .015 Hot spot uCBV (a.u.) 40.2 (16.8–181.3) 163 (142–274) .002 Hot spot rCBV 2.85 (1.75–7.45) 11.6 (6.48–18.50) .008 Hot spot Ktrans_Φ (min−1) 0.00054 (0.00017–0.01341) 0.047 (0.023–0.091) .0006 Hot spot Ktrans_SI (min−1) 0.016 (0.002–0.067) 0.095 (0.044–0.162) .02 Note:—a.u. indicates arbitrary units.
↵a Interquartile ranges are in parentheses.
- Table 2:
Diagnostic accuracy of imaging and histopathologic parameters in differentiating grade III and IV astrocytomas using hot spot ROIs
Parameters AUC 95% CI Cutoff Value Sensitivity (%) Specificity (%) MVA 0.78 0.60–0.90 <2.32 77 73 MVD 0.62 0.44–0.78 <103 95 36 Hot spot Vp_Φ 0.81 0.64–0.92 <1.88 91 73 Hot spot Vp_SI 0.66 0.47–0.81 <4.2 91 64 Hot spot uCBV 0.80 0.63–0.92 <141 86 73 Hot spot rCBV 0.70 0.51–0.85 <9.88 68 73 Hot spot Ktrans_Φ 0.78 0.60–0.90 <0.024 86 64 Hot spot Ktrans_SI 0.72 0.53–0.86 <0.056 82 64 Combined Vp_Φ + Ktrans_Φ + MVA + uCBV 0.85 0.68–0.95 <0.67 77 82 Note:—AUC indicates area under the curve.
- Table 3:
Median values for MVA and MVD with interquartile ranges for nonenhancing/poorly enhancing gliomas and moderately/strongly enhancing gliomasa
Tumor Enhancement MVA MVD None/poor (n = 16) 1.4% (0.68%–2.16%) 187 mm2 (92–255 mm2) Moderate/strong (n = 27) 4.9% (2.08%–10.19%) 408 mm2 (156–842 mm2) P value .0002 .04 ↵a Interquartile ranges are in parentheses.
Parameter MVA (95% CI) P Value MVD (95% CI) P Value Large-tumor Vp_Φ 0.74 (0.57–0.85) <.0001 0.52 (0.26–0.71) .0003 Large-tumor Vp_SI 0.52 (0.26–0.71) .0003 0.29 (−0.14–0.54) .06 Large-tumor uCBV 0.61 (0.37–0.77) <.0001 0.42 (0.14–0.64) .005 Large-tumor rCBV 0.50 (0.23–0.69) .0007 0.45 (0.18–0.66) .002 Large-tumor Ktrans_Φ 0.57 (0.33–0.75) .0001 0.36 (0.07–0.60) .02 Large-tumor Ktrans_SI 0.56 (0.32–0.74) .0001 0.41 (0.13–0.63) .006 Hot spot Vp_Φ 0.69 (0.49–0.82) <.0001 0.46 (0.18–0.66) .002 Hot spot Vp_SI 0.44 (0.16–0.65) .033 0.20 (−0.11–0.47) .2 Hot spot uCBV 0.68 (0.48–0.82) <.0001 0.48 (0.21–0.68) .001 Hot spot rCBV 0.55 (0.30–0.73) .0001 0.47 (0.20–0.68) .002 Hot spot Ktrans_Φ 0.56 (0.31–.74) .0001 0.37 (0.073–0.60) .02 Hot spot Ktrans_SI 0.54 (0.29–0.73) .0002 0.32 (0.024–0.57) .04
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