Article Figures & Data
Figures
- Fig 1.
Regional cerebral blood flow. Cerebral blood in the gray matter, white matter, normal-appearing white matter unaffected by WMHs (NAWM), and white matter hyperintensities. Shown are means (SDs) and P values of paired sample t tests.
- Fig 2.
Cerebral blood flow per quartiles of WMH load. Cerebral blood flow in the gray matter, normal-appearing white matter unaffected by WMHs, and white matter hyperintensities in subgroups based on quartiles of WMH volume. Shown are means (SDs) and significant P values of 1-way analysis of variance.
- Fig 3.
Scatterplots of relations between CBF and WMH volume, adjusted for total brain volume. Lines denote the regression line with 95% CI. Log WMH volume is logarithmically transformed.
Tables
Characteristics (n = 181) Age (yr) 77 (2) Female 96 (53%) MMSE 29 (28–30) BMI (kg/m2) 26 (24–28) History of stroke or TIA 19 (11%) History of cardiovascular disease 41 (23%) Diabetes mellitus 20 (11%) Smoking status Never 82 (45%) Former 88 (49%) Current 11 (6%) Antihypertensive drug use 108 (60%) World Health Organization hypertension grade: Normotension 47 (26%) Grade I hypertension 73 (41%) Grade II hypertension 38 (21%) Grade III hypertension 20 (11%) Systolic blood pressure (mm Hg) 148 (138–165) Diastolic blood pressure (mm Hg) 81 (74–90) Brain parenchymal fraction 0.61 (0.025) WMH volume (mL) 6.5 (3.6–11.2) Note:—MMSE indicates Mini-Mental State Examination; BMI, body mass index.
↵a Reported are means and SDs, numbers and valid percentages, or medians with interquartile range. Cardiovascular disease comprises peripheral arterial disease, angina pectoris, and myocardial infarction. Brain parenchymal fraction = (total cerebral volume)/total intracranial volume.
Predictor Model 1 Model 2 β P Value R2 β P Value R2 CBF in WMH −.248 .001 0.06 −.201 .029 0.06 CBF in NAWM −.035 .643 0.00 .175 .098 0.05 CBF in GM −.065 .382 0.00 .175 .133 0.05 ↵a R2 is the adjusted R2 representing the proportion of variation in white matter hyperintensity volume explained by all variables in the model, corrected for the number of variables—model 1: adjusted for total brain volume; model 2: adjusted for total brain volume, age, antihypertensive use, brain parenchymal fraction, and transit time.
