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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleADULT BRAIN
Open Access

Comparison of the Effect of Vessel Size Imaging and Cerebral Blood Volume Derived from Perfusion MR Imaging on Glioma Grading

H.-Y. Kang, H.-L. Xiao, J.-H. Chen, Y. Tan, X. Chen, T. Xie, J.-Q. Fang, S. Wang, Y. Yang and W.-G. Zhang
American Journal of Neuroradiology January 2016, 37 (1) 51-57; DOI: https://doi.org/10.3174/ajnr.A4477
H.-Y. Kang
aFrom Departments of Radiology (H.-Y.K., J.-H.C., H.-L.X., Y.T., X.C., T.X., J.-q.F., W.-G.Z.)
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H.-L. Xiao
aFrom Departments of Radiology (H.-Y.K., J.-H.C., H.-L.X., Y.T., X.C., T.X., J.-q.F., W.-G.Z.)
bPathology (H.-L.X.)
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J.-H. Chen
aFrom Departments of Radiology (H.-Y.K., J.-H.C., H.-L.X., Y.T., X.C., T.X., J.-q.F., W.-G.Z.)
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Y. Tan
aFrom Departments of Radiology (H.-Y.K., J.-H.C., H.-L.X., Y.T., X.C., T.X., J.-q.F., W.-G.Z.)
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X. Chen
aFrom Departments of Radiology (H.-Y.K., J.-H.C., H.-L.X., Y.T., X.C., T.X., J.-q.F., W.-G.Z.)
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T. Xie
aFrom Departments of Radiology (H.-Y.K., J.-H.C., H.-L.X., Y.T., X.C., T.X., J.-q.F., W.-G.Z.)
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J.-Q. Fang
aFrom Departments of Radiology (H.-Y.K., J.-H.C., H.-L.X., Y.T., X.C., T.X., J.-q.F., W.-G.Z.)
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S. Wang
dDepartments of Radiology (S.W.)
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Y. Yang
eMedicine (Y.Y.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
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W.-G. Zhang
aFrom Departments of Radiology (H.-Y.K., J.-H.C., H.-L.X., Y.T., X.C., T.X., J.-q.F., W.-G.Z.)
cState Key Laboratory of Trauma, Burns and Combined Injury (W.-G.Z.), Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
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    Fig 1.

    A 25-year-old woman with an oligodendroglioma (World Health Organization grade II). A, Axial T2-weighted MR imaging demonstrates a right frontal and temporal lobe lesion with mass effect, a small amount of edema, and signal-intensity heterogeneity. B, Contrast-enhanced T1-weighted imaging demonstrates mild enhancement. C, The VSI map shows homogeneous low VSI values and is represented in blue-green. D, CBV map demonstrates clearly elevated perfusion in the tumor parenchyma.

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    Fig 2.

    A 42-year-old woman with glioblastoma (World Health Organization grade IV). A, Axial T2-weighted MR imaging reveals a left temporal and occipital lobe lesion with mass effect, a moderate amount of edema, and homogeneous signal intensity. B, Contrast-enhanced T1-weighted imaging reveals marked enhancement. C, VSI map shows high VSI values. D, CBV map reveals the elevated perfusion more extensively. The highest perfusion region of CBV does not match entirely that of VSI.

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    Fig 3.

    VSI and rCBV values in predicting the grade of gliomas. A, The VSImean values show no overlap between HGG and LGG and provide 100% accuracy in predicting the glioma grade. B, The glioma grade could not be exactly identified on the basis of the cutoff values of rCBV. Black indicates the cases correctly identified, and red denotes the cases incorrectly identified.

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American Journal of Neuroradiology: 37 (1)
American Journal of Neuroradiology
Vol. 37, Issue 1
1 Jan 2016
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H.-Y. Kang, H.-L. Xiao, J.-H. Chen, Y. Tan, X. Chen, T. Xie, J.-Q. Fang, S. Wang, Y. Yang, W.-G. Zhang
Comparison of the Effect of Vessel Size Imaging and Cerebral Blood Volume Derived from Perfusion MR Imaging on Glioma Grading
American Journal of Neuroradiology Jan 2016, 37 (1) 51-57; DOI: 10.3174/ajnr.A4477

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Comparison of the Effect of Vessel Size Imaging and Cerebral Blood Volume Derived from Perfusion MR Imaging on Glioma Grading
H.-Y. Kang, H.-L. Xiao, J.-H. Chen, Y. Tan, X. Chen, T. Xie, J.-Q. Fang, S. Wang, Y. Yang, W.-G. Zhang
American Journal of Neuroradiology Jan 2016, 37 (1) 51-57; DOI: 10.3174/ajnr.A4477
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