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Research ArticleHead and Neck Imaging

Endolymphatic Hydrops Reversal following Acetazolamide Therapy: Demonstration with Delayed Intravenous Contrast-Enhanced 3D-FLAIR MRI

A.R. Sepahdari, N. Vorasubin, G. Ishiyama and A. Ishiyama
American Journal of Neuroradiology January 2016, 37 (1) 151-154; DOI: https://doi.org/10.3174/ajnr.A4462
A.R. Sepahdari
aFrom the Departments of Radiological Sciences (A.R.S.)
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N. Vorasubin
bHead and Neck Surgery (N.V., A.I.)
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G. Ishiyama
cNeurology (G.I.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
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A. Ishiyama
bHead and Neck Surgery (N.V., A.I.)
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    Fig 1.

    Normal appearance of cisternographic T2 (T2 SPACE) and heavily T2-weighted 3D FLAIR. A, Axial T2 SPACE source image through the midmodiolar level shows normal bright signal of fluid in the vestibule. Both endolymph and perilymph are bright by this technique. B, Axial hT2WI-FLAIR source image at the same level shows predominantly bright perilymphatic fluid in this part of the vestibule (short arrow), with a small signal void reflecting normal endolymphatic space near the ampulla of the posterior semicircular canal (long arrow). C, 3D maximum intensity projection of the T2 SPACE sequence shows the cochlea, vestibule, and semicircular canals in the same image, all with normal bright fluid signal. D, 3D MIP of the hT2WI-FLAIR sequence shows 2 small signal voids in the vestibule reflective of normal endolymphatic spaces (long arrows). The vestibule is predominantly filled with bright perilymph (short arrow).

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    Fig 2.

    A 42-year-old man with grade I vestibular hydrops, with reversal of symptoms and reversal of hydrops after treatment with acetazolamide. A, Pretreatment axial hT2WI-FLAIR source image through the vestibule shows dilated endolymphatic spaces effacing the vestibular perilymph (long arrow). Compare with the normal appearance of the inner ear in Fig 1B. B, Posttreatment axial hT2WI-FLAIR source image through the vestibule shows interval resolution of endolymphatic hydrops, with normal bright perilymph signal in the vestibule (short arrow). C, Pretreatment hT2WI-FLAIR 3D MIP shows dilated endolymphatic spaces effacing >50% of the vestibule (long arrow). D, Posttreatment hT2WI-FLAIR 3D MIP shows interval resolution of hydrops, with normal bright perilymph (short arrow) occupying >50% of the vestibule.

  • Fig 3.
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    Fig 3.

    A 72-year-old man with hydrops responsive to acetazolamide and recurrence after discontinuation of treatment. A, Pretreatment axial hT2WI-FLAIR source image through the vestibule shows marked hydrops with complete effacement of the normal bright vestibular perilymphatic fluid by dilated, dark endolymphatic space (long arrow). B, Posttreatment axial hT2WI-FLAIR, during treatment with acetazolamide, shows reversal of hydrops. Normal bright perilymphatic fluid is now visible (short arrows). C, Following discontinuation of acetazolamide and recurrence of symptoms, follow-up axial hT2WI-FLAIR image shows recurrence of hydrops (long arrow).

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American Journal of Neuroradiology: 37 (1)
American Journal of Neuroradiology
Vol. 37, Issue 1
1 Jan 2016
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A.R. Sepahdari, N. Vorasubin, G. Ishiyama, A. Ishiyama
Endolymphatic Hydrops Reversal following Acetazolamide Therapy: Demonstration with Delayed Intravenous Contrast-Enhanced 3D-FLAIR MRI
American Journal of Neuroradiology Jan 2016, 37 (1) 151-154; DOI: 10.3174/ajnr.A4462

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Endolymphatic Hydrops Reversal following Acetazolamide Therapy: Demonstration with Delayed Intravenous Contrast-Enhanced 3D-FLAIR MRI
A.R. Sepahdari, N. Vorasubin, G. Ishiyama, A. Ishiyama
American Journal of Neuroradiology Jan 2016, 37 (1) 151-154; DOI: 10.3174/ajnr.A4462
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