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Research ArticleExtracranial Vascular
Open Access

Characterization of Craniocervical Artery Dissection by Simultaneous MR Noncontrast Angiography and Intraplaque Hemorrhage Imaging at 3T

Q. Li, J. Wang, H. Chen, X. Gong, N. Ma, K. Gao, L. He, M. Guan, Z. Chen, R. Li, D. Mi, C. Yuan, X. Zhao and X.H. Zhao
American Journal of Neuroradiology September 2015, 36 (9) 1769-1775; DOI: https://doi.org/10.3174/ajnr.A4348
Q. Li
aFrom the Departments of Neurology (Q.L., X.G., D.M., X.Z.)
cDepartment of Neurology (Q.L.), People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China
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J. Wang
dClinical Sites Research Program (J.W.), Philips Research North America, Briarcliff Manor, New York
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H. Chen
eDepartment of Biomedical Engineering (H.C., L.H., Z.C., R.L., C.Y., X.H.Z.), Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China
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X. Gong
aFrom the Departments of Neurology (Q.L., X.G., D.M., X.Z.)
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N. Ma
bInterventional Neuroradiology (N.M., K.G.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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K. Gao
bInterventional Neuroradiology (N.M., K.G.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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L. He
eDepartment of Biomedical Engineering (H.C., L.H., Z.C., R.L., C.Y., X.H.Z.), Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China
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M. Guan
fDepartment of Radiology (M.G.), Yangzhou First People's Hospital, Yangzhou, China
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Z. Chen
eDepartment of Biomedical Engineering (H.C., L.H., Z.C., R.L., C.Y., X.H.Z.), Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China
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R. Li
eDepartment of Biomedical Engineering (H.C., L.H., Z.C., R.L., C.Y., X.H.Z.), Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China
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D. Mi
aFrom the Departments of Neurology (Q.L., X.G., D.M., X.Z.)
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C. Yuan
eDepartment of Biomedical Engineering (H.C., L.H., Z.C., R.L., C.Y., X.H.Z.), Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China
gDepartment of Radiology (C.Y.), University of Washington, Seattle, Washington.
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X. Zhao
aFrom the Departments of Neurology (Q.L., X.G., D.M., X.Z.)
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X.H. Zhao
eDepartment of Biomedical Engineering (H.C., L.H., Z.C., R.L., C.Y., X.H.Z.), Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China
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  • Fig 1.
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    Fig 1.

    Excellent agreement between SNAP imaging and TOF MRA in measuring stenosis. Mild stenosis in the basilar artery is determined by MRA images derived from SNAP imaging (A), which corresponds to the TOF MRA image (B). The hyperintense signal on the SNAP vessel wall image (C) indicates intramural hematoma.

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    Fig 2.

    SNAP imaging depicts intramural hematoma. The intramural hematoma in the internal carotid artery appears hyperintense on both 3D MERGE (A, white arrows) and SNAP images (B, white arrows).

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    Fig 3.

    SNAP imaging delineates the intimal flaps. The SNAP MRA image (A) shows a dilated lumen (pseudoaneurysm) in the internal carotid artery. The intimal flaps (hollow arrow) and double lumen (white arrow) are noted on vessel wall images derived from SNAP imaging in the coronal (B) and axial (C) views after MPR reconstruction. The white line on the coronal view indicates the location of the axial view acquisition.

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    Fig 4.

    The luminal narrowing and intramural hematoma are jointly visualized in a single SNAP image. Total occlusion in the internal carotid artery is demonstrated by TOF MRA (A, hollow arrow) and SNAP MRA (C, hollow arrow). A vessel wall image (B) derived from SNAP imaging shows a hyperintense lesion in the vessel wall (white arrows), indicating intramural hematoma. The intramural hematoma is well-depicted by maximum intensity projection of SNAP images (D). The MRA and vessel wall images derived from SNAP imaging are naturally registered to jointly visualize luminal narrowing and intramural hematoma in red (E) after color-coded processing.

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    Table 1:

    Clinical characteristics of study population

    CharacteristicsMean or No. (%)Range (if Applicable)
    Age (yr)45.0 ± 16.114–70
    Male sex21 (87.5)
    Weight (kg)75.1 ± 8.560–90
    Height (cm)171.2 ± 5.5160–183
    Smoking10 (41.7)
    Hypertension13 (54.2)
    Diabetes6 (25)
    High-density lipoprotein (mmol/L)1.0 ± 0.20.5–1.8
    Low-density lipoprotein (mmol/L)2.3 ± 0.81.0–5.7
    Total cholesterol (mmol/L)4.0 ± 1.12.2–7.8
    Triglycerides (mmol/L)1.5 ± 0.70.6–3.0
    Headache4 (16.7)
    Neck pain3 (12.5)
    Ischemic stroke20 (83.3)
    Transient ischemic attack4 (16.7)
    • View popup
    Table 2:

    Characteristics of 24 patients with CCAD on multisequence MR imaging

    Patient No.Sex/Age (yr)LocationLength (mm)Category of StenosisaPresence or Absence
    IMHPseudo-aneurysmIntimal Flaps and Double Lumen
    1M/65BA16.7Moderate+––
    2M/24MCA8.1Occlusion+––
    3M/14MCA6.0Mild+––
    4M/53ICA (C1)35.8No stenosis–++
    5M/20BA12.7No stenosis––+
    6M/40ICA (C1)70.2Occlusion+––
    7M/62BA and VA44.1Occlusion+––
    8M/59BA22.2No stenosis–+–
    9M/36MCA10.7No stenosis––+
    10F/18CCA23.3Occlusion+––
    11M/34VA10.1Moderate–––
    12F/38ICA (C1)42.4Severe+––
    13F/66CCA44.8No stenosis+––
    14M/43VA7.5Occlusion+––
    15M/62ICA (C1)40Severe+––
    16M/68CCA37.1Occlusion+––
    17M/42VA24.8Occlusion+––
    18M/35ICA (C1)63.4Occlusion+––
    19M/51BA and VA50.8Mild+––
    20M/69ICA (C1)57Occlusion+––
    21M/56ICA (C1)66.4Severe+––
    22M/40ICA (C1)13.6Occlusion+––
    23M/41VA42.7Occlusion+––
    24M/43BA11.6Moderate+–+
    • Note:—BA indicates basilar artery; VA, vertebral artery; CCA, common carotid artery; +, positive; –, negative.

    • ↵a Mild stenosis, 1%–49%; moderate stenosis, 50%–69%; severe stenosis, 70%–99%; occlusion, 100%.

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American Journal of Neuroradiology: 36 (9)
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Q. Li, J. Wang, H. Chen, X. Gong, N. Ma, K. Gao, L. He, M. Guan, Z. Chen, R. Li, D. Mi, C. Yuan, X. Zhao, X.H. Zhao
Characterization of Craniocervical Artery Dissection by Simultaneous MR Noncontrast Angiography and Intraplaque Hemorrhage Imaging at 3T
American Journal of Neuroradiology Sep 2015, 36 (9) 1769-1775; DOI: 10.3174/ajnr.A4348

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Characterization of Craniocervical Artery Dissection by Simultaneous MR Noncontrast Angiography and Intraplaque Hemorrhage Imaging at 3T
Q. Li, J. Wang, H. Chen, X. Gong, N. Ma, K. Gao, L. He, M. Guan, Z. Chen, R. Li, D. Mi, C. Yuan, X. Zhao, X.H. Zhao
American Journal of Neuroradiology Sep 2015, 36 (9) 1769-1775; DOI: 10.3174/ajnr.A4348
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