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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

The Curved MCA: Influence of Vessel Anatomy on Recanalization Results of Mechanical Thrombectomy after Acute Ischemic Stroke

B.J. Schwaiger, A.S. Gersing, C. Zimmer and S. Prothmann
American Journal of Neuroradiology May 2015, 36 (5) 971-976; DOI: https://doi.org/10.3174/ajnr.A4222
B.J. Schwaiger
aFrom the Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.
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A.S. Gersing
aFrom the Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.
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C. Zimmer
aFrom the Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.
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S. Prothmann
aFrom the Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.
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    Fig 1.

    First and second columns (patients 1 and 2) show pre- (a) and postprocedural (b) angiograms of patients with a proximal M1 occlusion as well as schematics of the vessel anatomy (c). The thrombus site is hatched red and yellow. In patient 1, the ICA/M1 was 53° and the M1/M1 was 18°, and he was successfully recanalized (TICI 3). Patient 2 presented with an ICA/M1 of 140° and an M1/M1 of 105°. In this patient, thrombectomy was unsuccessful (TICI 0). Third and fourth columns (patients 3 and 4) show pre- (a) and postprocedural (b) angiograms of patients with a proximal M2 occlusion as well as vessel schematics (c). While patient 3 presented with an M1/M2 angle of 51° and was successfully recanalized (TICI 3), in patient 4, an M1/M2 angle of 128° was measured and thrombectomy was unsuccessful (TICI 1).

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    Table 1:

    Epidemiologic, clinical, and technical parameters for all patients and a comparison between subgroups, depending on recanalization success

    ParameterAll PatientsTICI 0–2aTICI 2b/3P Value
    Group/subgroup size15924 (15.1%)135 (84.9%)
    Female sex (No., % of subgroup)79 (49.7%)11 (45.8%)68 (50.4%).825
    Age (yr, mean)70 ± 12.870 ± 10.770 ± 13.2.964
    Wake-up (No., % of subgroup)30 (18.9%)3 (12.5%)27 (20%).572
    Time symptom onset to puncture (min, mean)a230 ± 80.0232 ± 82.6230 ± 79.9.902
    Procedure time (min, mean)b55 ± 35.169 ± 38.253 ± 34.3.058
    Time onset to recanalization (min, mean)c285 ± 86.9303 ± 96.7283 ± 85.4.349
    NIHSS score at admission (median, range)15 (4–27)16 (7–24)14 (4–27).198
    IV rtPA administered (No., % of subgroup)112 (70.4%)15 (62.5%)97 (71.9%).345
    General anesthesia applied (No., % of subgroup)127 (79.9%)20 (83.3%)107 (79.3%).787
    Passages of device (No., median, range)2 (1–12)4 (1–10)2 (1–12).008d
    <1 Device used (No., % of subgroup)55 (34.6%)14 (58.3%)41 (30%).011d
    • ↵a Data missing for 24 patients.

    • ↵b Data missing for 9 patients.

    • ↵c Data missing for 21 patients.

    • ↵d Significant at P < .05.

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    Table 2:

    Angles, P values, AUCs for ROC analyses, and optimal cutoff values to differentiate TICI subgroups and Youden indices for different vessel anglesa

    Occlusion PatternGroup SizeAngleTICI 0–2a (mean)TICI 2b/3 (mean)PROC AUCCutoff and Youden index
    Proximal (carotid T or proximal M1 segment)125ICA/M1110 ± 23.869 ± 28.7.000b.872d100° (J = 0.69)
    125M1/M156 ± 29.229 ± 26.6.001b.759d36° (J = 0.40)
    Distal (distal M1 or proximal M2 segment)36M1/M2117 ± 34.367 ± 29.5.006c.865d97° (J = 0.64)
    • Note:—AUC indicates area under the curve.

    • ↵a P values significant at P < .05.

    • ↵b Corrected for age, sex, and IV rtPA (yes/no).

    • ↵c Corrected for age.

    • ↵d Significant at P < .005.

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American Journal of Neuroradiology: 36 (5)
American Journal of Neuroradiology
Vol. 36, Issue 5
1 May 2015
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B.J. Schwaiger, A.S. Gersing, C. Zimmer, S. Prothmann
The Curved MCA: Influence of Vessel Anatomy on Recanalization Results of Mechanical Thrombectomy after Acute Ischemic Stroke
American Journal of Neuroradiology May 2015, 36 (5) 971-976; DOI: 10.3174/ajnr.A4222

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The Curved MCA: Influence of Vessel Anatomy on Recanalization Results of Mechanical Thrombectomy after Acute Ischemic Stroke
B.J. Schwaiger, A.S. Gersing, C. Zimmer, S. Prothmann
American Journal of Neuroradiology May 2015, 36 (5) 971-976; DOI: 10.3174/ajnr.A4222
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