Cerebral Microbleeds: Different Prevalence, Topography, and Risk Factors Depending on Dementia Diagnosis—The Karolinska Imaging Dementia Study

REFERENCES

1. 1.↵
   2. Fazekas F,
   3. Kleinert R,
   4. Roob G, et al

   . Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999;20:637–42

   Abstract/FREE Full Text
2. 2.↵
   2. Gregoire SM,
   3. Chaudhary UJ,
   4. Brown MM, et al

   . The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds. Neurology 2009;73:1759–66

   CrossRef
3. 3.↵
   2. Auer RN,
   3. Sutherland GR

   . Primary intracerebral hemorrhage: pathophysiology. Can J Neurol Sci 2005;32(suppl 2):S3–12

   PubMedWeb of Science
4. 4.↵
   2. Jellinger KA

   . Alzheimer disease and cerebrovascular pathology: an update. J Neural Transm 2002:109:813–36

   CrossRefPubMedWeb of Science
5. 5.↵
   2. Skoog I

   . The relationship between blood pressure and dementia: a review. Biomed Pharmacother 1997;51:367–75

   CrossRefPubMed
6. 6.↵
   2. Pettersen JA,
   3. Sathiyamoorthy G,
   4. Gao FQ, et al

   . Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol 2008;65:790–95

   CrossRefPubMedWeb of Science
7. 7.↵
   2. Nakata-Kudo Y,
   3. Mizuno T,
   4. Yamada K, et al

   . Microbleeds in Alzheimer disease are more related to cerebral amyloid angiopathy than cerebrovascular disease. Dement Geriatr Cogn Disord 2006;22:8–14

   CrossRefPubMedWeb of Science
8. 8.↵
   2. Cordonnier C,
   3. van der Flier WM,
   4. Sluimer JD, et al

   . Prevalence and severity of microbleeds in a memory clinic setting. Neurology 2006;66:1356–60

   CrossRef
9. 9.↵
   2. Roob G,
   3. Schmidt R,
   4. Kapeller P, et al

   . MRI evidence of past cerebral microbleeds in a healthy elderly population. Neurology 1999;52:991–94

   CrossRef
10. 10.↵
    2. Jeerakathil T,
    3. Wolf PA,
    4. Beiser A, et al

    . Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study. Stroke 2004;35:1831–35

    Abstract/FREE Full Text
11. 11.↵
    2. Sveinbjornsdottir S,
    3. Sigurdsson S,
    4. Aspelund T, et al

    . Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location. J Neurol Neurosurg Psychiatry 2008;79:1002–06

    Abstract/FREE Full Text
12. 12.↵
    2. Tsushima Y,
    3. Tanizaki Y,
    4. Aoki J, et al

    . MR detection of microhemorrhages in neurologically healthy adults. Neuroradiology 2002;44:31–36

    CrossRefPubMedWeb of Science
13. 13.↵
    2. Hanyu H,
    3. Tanaka Y,
    4. Shimizu S, et al

    . Cerebral microbleeds in Alzheimer's disease. J Neurol 2003;250:1496–97

    CrossRefPubMedWeb of Science
14. 14.↵
    2. Nakata Y,
    3. Shiga K,
    4. Yoshikawa K, et al

    . Subclinical brain hemorrhages in Alzheimer's disease: evaluation by magnetic resonance T2*-weighted images. Ann N Y Acad Sci 2002;977:169–72

    CrossRefPubMedWeb of Science
15. 15.↵
    2. Fukui T,
    3. Oowan Y,
    4. Yamazaki T, et al

    . Prevalence and clinical implication of microbleeds in dementia with Lewy bodies in comparison with microbleeds in Alzheimer's disease. Dement Geriatr Cogn Dis Extra 2013;3:148–60

    CrossRefPubMed
16. 16.↵
    2. Cordonnier C,
    3. van der Flier WM

    . Brain microbleeds and Alzheimer's disease: innocent observation or key player? Brain 2011:134(pt 2):335–44

    Abstract/FREE Full Text
17. 17.↵
    2. Lee SH,
    3. Bae HJ,
    4. Kwon SJ, et al

    . Cerebral microbleeds are regionally associated with intracerebral hemorrhage. Neurology 2004;62:72–76

    CrossRef
18. 18.↵
    2. Landis JR,
    3. Koch GG

    . The measurement of observer agreement for categorical data. Biometrics 1977;33:159–74

    CrossRefPubMedWeb of Science
19. 19.↵
    2. Uetani H,
    3. Hirai T,
    4. Hashimoto M, et al

    . Prevalence and topography of small hypointense foci suggesting microbleeds on 3T susceptibility-weighted imaging in various types of dementia. AJNR Am J Neuroradiol 2013;34:984–89

    Abstract/FREE Full Text
20. 20.↵
    2. Brundel M,
    3. Heringa SM,
    4. de Bresser J, et al

    . High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease. J Alzheimers Dis 2012;31:259–63

    PubMed
21. 21.↵
    2. Nandigam RNK,
    3. Viswanathan A,
    4. Delgado P, et al

    . MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength. AJNR Am J Neuroradiol 2009;30:338–43

    Abstract/FREE Full Text
22. 22.↵
    2. Dierksen GA,
    3. Skehan ME,
    4. Khan MA, et al

    . Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann Neurol 2010;68:545–48

    CrossRefPubMedWeb of Science
23. 23.↵
    2. Park JH,
    3. Seo SW,
    4. Kim C, et al

    . Pathogenesis of cerebral microbleeds: in vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment. Ann Neurol 2013;73:584–93

    CrossRefPubMed
24. 24.↵
    2. Gurol ME,
    3. Dierksen G,
    4. Betensky R, et al

    . Predicting sites of new hemorrhage with amyloid imaging in cerebral amyloid angiopathy. Neurology 2012;79:320–26

    CrossRef
25. 25.↵
    2. Greenberg SM,
    3. Vernooij MW,
    4. Cordonnier C, et al

    . Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 2009;8:165–74

    CrossRefPubMedWeb of Science
26. 26.↵
    2. Werring DJ

    , ed. Cerebral Microbleeds: Pathophysiology to Clinical Practice. Cambridge: Cambridge University Press; 2011
27. 27.↵
    2. Poels MM,
    3. Vernooij MW,
    4. Ikram MA, et al

    . Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study. Stroke 2010:41(10 suppl):S103–06

    Abstract/FREE Full Text
28. 28.↵
    2. Wiegman AF,
    3. Meier IB,
    4. Schupf N, et al

    . Cerebral microbleeds in a multiethnic elderly community: demographic and clinical correlates. J Neurol Sci 2014;345:125–30

    CrossRefPubMed
29. 29.↵
    2. Romero JR,
    3. Preis SR,
    4. Beiser A, et al

    . Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study. Stroke 2014;45:1492–94

    Abstract/FREE Full Text
30. 30.↵
    2. Vinters HV,
    3. Gilbert JJ

    . Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. Stroke 1983;14:924–28

    Abstract/FREE Full Text
31. 31.↵
    2. Biffi A,
    3. Greenberg SM

    . Cerebral amyloid angiopathy: a systematic review. J Clin Neurol 2011;7:1–9

    CrossRefPubMed
32. 32.↵
    2. Rosand J,
    3. Muzikansky A,
    4. Kumar A, et al

    . Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Ann Neurol 2005;58:459–62

    CrossRefPubMedWeb of Science
33. 33.↵
    2. Attems J,
    3. Jellinger KA,
    4. Lintner F

    . Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy. Acta Neuropathol 2005;110:222–31

    CrossRefPubMed