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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention
Open Access

Comparison of Modern Stroke Thrombectomy Approaches Using an In Vitro Cerebrovascular Occlusion Model

M. Mokin, S.V. Setlur Nagesh, C.N. Ionita, E.I. Levy and A.H. Siddiqui
American Journal of Neuroradiology March 2015, 36 (3) 547-551; DOI: https://doi.org/10.3174/ajnr.A4149
M. Mokin
aFrom the Departments of Neurosurgery (M.M., E.I.L., A.H.S.)
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S.V. Setlur Nagesh
bBiomedical Engineering (S.V.S.N., C.N.I.)
cElectrical Engineering (S.V.S.N.)
dMechanical and Aerospace Engineering (S.V.S.N.)
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C.N. Ionita
bBiomedical Engineering (S.V.S.N., C.N.I.)
fToshiba Stroke and Vascular Research Center (C.N.I., E.I.L., A.H.S.), University at Buffalo, State University of New York, Buffalo, New York
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E.I. Levy
aFrom the Departments of Neurosurgery (M.M., E.I.L., A.H.S.)
eRadiology (E.I.L., A.H.S.)
fToshiba Stroke and Vascular Research Center (C.N.I., E.I.L., A.H.S.), University at Buffalo, State University of New York, Buffalo, New York
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A.H. Siddiqui
aFrom the Departments of Neurosurgery (M.M., E.I.L., A.H.S.)
eRadiology (E.I.L., A.H.S.)
fToshiba Stroke and Vascular Research Center (C.N.I., E.I.L., A.H.S.), University at Buffalo, State University of New York, Buffalo, New York
gJacobs Institute (A.H.S.), Buffalo, New York.
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    Fig 1.

    Combined Stentriever plus aspiration approach to thrombectomy. A, Baseline angiogram, anteroposterior view, left ICA injection, demonstrating occlusion at the MCA origin (white arrow). ACA indicates anterior cerebral artery. B, Combined left ICA and microcatheter injection shows the extent of the thrombus within the left MCA (dotted black lines). Black arrow points to the tip of the microcatheter within an M2 branch of the MCA. C, Solitaire FR stent retriever is deployed within the M1 MCA segment. Black arrow points to the distal tip of the 5MAX ACE reperfusion catheter. D, Final angiogram after successful thrombectomy shows robust filling of the left MCA branches except for some distal superior trunk vessels. The final recanalization grade is TICI 2b.

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    Fig 2.

    A, Rates of TICI 2b or 3 recanalization achieved with different thrombectomy approaches. “Guide + Stentriever” represents the primary Stentriever approach by using a conventional guide catheter. “BGC + Stentriever” represents the primary Stentriever approach by using a balloon-guide catheter. “Stentriever + aspiration” represents the combined Stentriever plus continuous aspiration approach. “Direct aspiration” represents thrombectomy performed by using the direct aspiration approach without the use of a Stentriever. B, Rates of embolization of new territories with different thrombectomy approaches. C, Rates of embolization of distal territories with different thrombectomy approaches.

Tables

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    Conventional Guide + Stentriever (n = 19)Balloon-Guide + Stentriever (n = 20)Stentriever + Aspiration (n = 17)Direct Aspiration (n = 15)
    TICI score
        0 (No.) (%)7 (37%)8 (40%)0 (0%)0 (0%)
        1 (No.) (%)2 (11%)0 (0%)1 (6%)0 (0%)
        2a (No.) (%)3 (16%)1 (5%)2 (12%)0 (0%)
        2b (No.) (%)2 (11%)3 (15%)3 (18%)2 (13%)
        3 (No.) (%)5 (26%)8 (40%)11 (65%)13 (87%)
        2b or 3 (No.) (%)7 (37%)11 (55%)14 (82%)15 (100%)
    Embolic events
        Embolization of new territories (No.) (%)10 (53%)2 (10%)2 (12%)0 (0%)
        Embolization of distal territories (No.) (%)3 (16%)3 (15%)4 (24%)2 (13%)
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American Journal of Neuroradiology: 36 (3)
American Journal of Neuroradiology
Vol. 36, Issue 3
1 Mar 2015
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M. Mokin, S.V. Setlur Nagesh, C.N. Ionita, E.I. Levy, A.H. Siddiqui
Comparison of Modern Stroke Thrombectomy Approaches Using an In Vitro Cerebrovascular Occlusion Model
American Journal of Neuroradiology Mar 2015, 36 (3) 547-551; DOI: 10.3174/ajnr.A4149

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Comparison of Modern Stroke Thrombectomy Approaches Using an In Vitro Cerebrovascular Occlusion Model
M. Mokin, S.V. Setlur Nagesh, C.N. Ionita, E.I. Levy, A.H. Siddiqui
American Journal of Neuroradiology Mar 2015, 36 (3) 547-551; DOI: 10.3174/ajnr.A4149
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