Imaging Evidence and Recommendations for Traumatic Brain Injury: Advanced Neuro- and Neurovascular Imaging Techniques

REFERENCES

1. 1.↵
   2. Faul M,
   3. Xu L,
   4. Wald M, et al

   . Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002–2006. Atlanta: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; 2010
2. 2.↵
   2. Marin JR,
   3. Weaver MD,
   4. Yealy DM, et al

   . Trends in visits for traumatic brain injury to emergency departments in the United States. JAMA 2014;311:1917–19

   CrossRefPubMed
3. 3.↵
   2. Ilie G,
   3. Boak A,
   4. Adlaf EM, et al

   . Prevalence and correlates of traumatic brain injuries among adolescents. JAMA 2013;309:2550–52

   CrossRefPubMedWeb of Science
4. 4.↵
   2. Gean AD

   . Brain Injury: Applications from War and Terrorism. Lippincott Williams & Wilkins; 2014
5. 5.↵
   National Center for Injury Prevention and Control. Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to Prevent a Serious Public Health Problem. Atlanta: Centers for Disease Control and Prevention; 2003
6. 6.↵
   Centers for Disease Control and Prevention. Injury Prevention and Control: Traumatic Brain Injury. http://www.cdc.gov/traumaticbraininjury/. . Updated March 6, 2014Accessed October 30, 2014.
7. 7.↵
   Congressional Budget Office. The Veterans Health Administration's Treatment of PTSD and Traumatic Brain Injury Among Recent Combat Veterans. http://www.cbo.gov/sites/default/files/cbofiles/attachments/02-09-PTSD.pdf. Accessed October 20, 2014. February 2012.
8. 8.↵
   2. Basser PJ,
   3. Mattiello J,
   4. LeBihan D

   . Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 1994;103:247–54

   CrossRefPubMedWeb of Science
9. 9.↵
   2. Davenport ND,
   3. Lim KO,
   4. Armstrong MT, et al

   . Diffuse and spatially variable white matter disruptions are associated with blast-related mild traumatic brain injury. Neuroimage 2012;59:2017–24

   CrossRefPubMedWeb of Science
10. 10.↵
    2. Mayer AR,
    3. Ling JM,
    4. Yang Z, et al

    . Diffusion abnormalities in pediatric mild traumatic brain injury. J Neurosci 2012;32:17961–69

    Abstract/FREE Full Text
11. 11.↵
    2. Ling JM,
    3. Peña A,
    4. Yeo RA, et al

    . Biomarkers of increased diffusion anisotropy in semi-acute mild traumatic brain injury: a longitudinal perspective. Brain 2012;135:1281–92

    Abstract/FREE Full Text
12. 12.↵
    2. Wilde EA,
    3. McCauley SR,
    4. Hunter JV, et al

    . Diffusion tensor imaging of acute mild traumatic brain injury in adolescents. Neurology 2008;70:948–55

    CrossRef
13. 13.↵
    2. Chu Z,
    3. Wilde EA,
    4. Hunter JV, et al

    . Voxel-based analysis of diffusion tensor imaging in mild traumatic brain injury in adolescents. AJNR Am J Neuroradiol 2010;31:340–46

    Abstract/FREE Full Text
14. 14.↵
    2. Mayer AR,
    3. Ling J,
    4. Mannell MV, et al

    . A prospective diffusion tensor imaging study in mild traumatic brain injury. Neurology 2010;74:643–50

    CrossRef
15. 15.↵
    2. Smith SM,
    3. Jenkinson M,
    4. Johansen-Berg H, et al

    . Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006;31:1487–505

    CrossRefPubMedWeb of Science
16. 16.↵
    2. Bouix S,
    3. Pasternak O,
    4. Rathi Y, et al

    . Increased gray matter diffusion anisotropy in patients with persistent post-concussive symptoms following mild traumatic brain injury. PLoS One 2013;8:e66205

    CrossRefPubMed
17. 17.↵
    2. Tuch DS,
    3. Reese TG,
    4. Wiegell MR, et al

    . High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity. Magn Reson Med 2002;48:577–82

    CrossRefPubMedWeb of Science
18. 18.↵
    2. Jensen JH,
    3. Helpern JA

    . MRI quantification of non-Gaussian water diffusion by kurtosis analysis. NMR Biomed 2010;23:698–710

    CrossRefPubMedWeb of Science
19. 19.↵
    2. Fieremans E,
    3. Benitez A,
    4. Jensen JH, et al

    . Novel white matter tract integrity metrics sensitive to Alzheimer disease progression. AJNR Am J Neuroradiol 2013;34:2105–12

    Abstract/FREE Full Text
20. 20.↵
    2. Jensen JH,
    3. Helpern JA,
    4. Tabesh A

    . Leading non-Gaussian corrections for diffusion orientation distribution function. NMR Biomed 2014;27:202–11

    CrossRefPubMed
21. 21.↵
    2. Wedeen VJ,
    3. Hagmann P,
    4. Tseng WY, et al

    . Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magn Reson Med 2005;54:1377–86

    CrossRefPubMedWeb of Science
22. 22.↵
    2. Tuch DS

    . Q-ball imaging. Magnet Reson Med 2004;52:1358–72

    CrossRef
23. 23.↵
    2. Feinberg DA,
    3. Moeller S,
    4. Smith SM, et al

    . Multiplexed echo planar imaging for sub-second whole brain FMRI and fast diffusion imaging. PLoS One 2010;5:e15710

    CrossRefPubMed
24. 24.↵
    2. Zhang H,
    3. Schneider T,
    4. Wheeler-Kingshott CA, et al

    . NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. Neuroimage 2012;61:1000–16

    CrossRefPubMedWeb of Science
25. 25.↵
    2. Tournier J,
    3. Calamante F,
    4. Connelly A

    . Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. Neuroimage 2007;35:1459–72

    CrossRefPubMedWeb of Science
26. 26.↵
    2. Xu D,
    3. Maier JK,
    4. King KF, et al

    . Prospective and retrospective high order eddy current mitigation for diffusion weighted echo planar imaging. Magnet Reson Med 2013;70:1293–305

    CrossRef
27. 27.↵
    2. Wilde EA,
    3. Ramos MA,
    4. Yallampalli R, et al

    . Diffusion tensor imaging of the cingulum bundle in children after traumatic brain injury. Dev Neuropsychol 2010;35:333–51

    CrossRefPubMed
28. 28.↵
    2. Arfanakis K,
    3. Haughton VM,
    4. Carew JD, et al

    . Diffusion tensor MR imaging in diffuse axonal injury. AJNR Am J Neuroradiol 2002;23:794–802

    Abstract/FREE Full Text
29. 29.↵
    2. Kumar R,
    3. Gupta RK,
    4. Husain M, et al

    . Comparative evaluation of corpus callosum DTI metrics in acute mild and moderate traumatic brain injury: its correlation with neuropsychometric tests. Brain Inj 2009;23:675–85

    CrossRefPubMedWeb of Science
30. 30.↵
    2. Miles L,
    3. Grossman RI,
    4. Johnson G, et al

    . Short-term DTI predictors of cognitive dysfunction in mild traumatic brain injury. Brain Inj 2008;22:115–22

    CrossRefPubMedWeb of Science
31. 31.↵
    2. Newcombe VF,
    3. Williams GB,
    4. Nortje J, et al

    . Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma. Acta Neurochir Suppl 2008;102:247–51

    CrossRefPubMed
32. 32.↵
    2. Newcombe VF,
    3. Williams GB,
    4. Nortje J, et al

    . Analysis of acute traumatic axonal injury using diffusion tensor imaging. Br J Neurosurg 2007;21:340–48

    CrossRefPubMedWeb of Science
33. 33.↵
    2. Wozniak JR,
    3. Lim KO

    . Advances in white matter imaging: a review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging. Neurosci Biobehav Rev 2006;30:762–74

    CrossRefPubMedWeb of Science
34. 34.↵
    2. Wozniak JR,
    3. Krach L,
    4. Ward E, et al

    . Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: a diffusion tensor imaging (DTI) study. Arch Clin Neuropsychol 2007;22:555–68

    Abstract/FREE Full Text
35. 35.↵
    2. Aoki Y,
    3. Inokuchi R,
    4. Gunshin M, et al

    . Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis. J Neurol Neurosurg Psychiatry 2012;83:870–76

    Abstract/FREE Full Text
36. 36.↵
    2. Brandstack N,
    3. Kurki T,
    4. Tenovuo O

    . Quantitative diffusion-tensor tractography of long association tracts in patients with traumatic brain injury without associated findings at routine MR imaging. Radiology 2013;267:231–39

    CrossRefPubMed
37. 37.↵
    2. McAllister TW,
    3. Ford JC,
    4. Ji S, et al

    . Maximum principal strain and strain rate associated with concussion diagnosis correlates with changes in corpus callosum white matter indices. Ann Biomed Eng 2012;40:127–40

    CrossRefPubMed
38. 38.↵
    2. Henry LC,
    3. Tremblay J,
    4. Tremblay S, et al

    . Acute and chronic changes in diffusivity measures after sports concussion. J Neurotrauma 2011;28:2049–59

    CrossRefPubMedWeb of Science
39. 39.↵
    2. Bazarian JJ,
    3. Zhong J,
    4. Blyth B, et al

    . Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study. J Neurotrauma 2007;24:1447–59

    CrossRefPubMedWeb of Science
40. 40.↵
    2. Bazarian JJ,
    3. Zhu T,
    4. Blyth B, et al

    . Subject-specific changes in brain white matter on diffusion tensor imaging after sports-related concussion. Magn Reson Imaging 2012;30:171–80

    CrossRefPubMedWeb of Science
41. 41.↵
    2. Eierud C,
    3. Craddock RC,
    4. Fletcher S, et al

    . Neuroimaging after mild traumatic brain injury: review and meta-analysis. Neuroimage Clin 2014;4:283–94

    CrossRefPubMed
42. 42.↵
    2. Hulkower M,
    3. Poliak D,
    4. Rosenbaum S, et al

    . A decade of DTI in traumatic brain injury: 10 years and 100 articles later. AJNR Am J Neuroradiol 2013;34:2064–74

    Abstract/FREE Full Text
43. 43.↵
    2. Fakhran S,
    3. Yaeger K,
    4. Alhilali L

    . Symptomatic white matter changes in mild traumatic brain injury resemble pathologic features of early Alzheimer dementia. Radiology 2013;269:249–57

    CrossRefPubMed
44. 44.↵
    2. Shenton M,
    3. Hamoda H,
    4. Schneiderman J, et al

    . A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging Behav 2012;6:137–92

    CrossRefPubMedWeb of Science
45. 45.↵
    2. Niogi SN,
    3. Mukherjee P

    . Diffusion tensor imaging of mild traumatic brain injury. J Head Trauma Rehabil 2010;25:241–55

    CrossRefPubMedWeb of Science
46. 46.↵
    2. Logothetis NK,
    3. Pauls J,
    4. Augath M, et al

    . Neurophysiological investigation of the basis of the fMRI signal. Nature 2001;412:150–57

    CrossRefPubMedWeb of Science
47. 47.↵
    2. Heeger DJ,
    3. Ress D

    . What does fMRI tell us about neuronal activity? Nat Rev Neurosci 2002;3:142–51

    CrossRefPubMedWeb of Science
48. 48.↵
    2. Arthurs OJ,
    3. Boniface S

    . How well do we understand the neural origins of the fMRI BOLD signal? Trends Neurosci 2002;25:27–31

    CrossRefPubMedWeb of Science
49. 49.↵
    2. Attwell D,
    3. Iadecola C

    . The neural basis of functional brain imaging signals. Trends Neurosci 2002;25:621–25

    CrossRefPubMedWeb of Science
50. 50.↵
    2. Nair DG

    . About being BOLD. Brain Res Brain Res Rev 2005;50:229–43

    CrossRefPubMed
51. 51.↵
    2. Jantzen KJ

    . Functional magnetic resonance imaging of mild traumatic brain injury. J Head Trauma Rehab 2010;25:256–66

    CrossRefPubMed
52. 52.↵
    1. Silver JM,
    2. McAllister TW,
    3. Yudofsky SC

    2. Freeman JR,
    3. Barth JT,
    4. Broshek DK, et al

    . Sports injuries. In: Silver JM, McAllister TW, Yudofsky SC, eds. Textbook of Traumatic Brain Injury. Washington, DC: American Psychiatric Publishing Inc; 2005:453–76
53. 53.↵
    2. Bullock R,
    3. Zauner A,
    4. Woodward JJ, et al

    . Factors affecting excitatory amino acid release following severe human head injury. J Neurosurg 1998;89:507–18

    CrossRefPubMedWeb of Science
54. 54.↵
    2. Garnett MR,
    3. Blamire AM,
    4. Rajagopalan B, et al

    . Evidence for cellular damage in normal-appearing white matter correlates with injury severity in patients following traumatic brain injury: a magnetic resonance spectroscopy study. Brain 2000;123(pt 7):1403–09

    Abstract/FREE Full Text
55. 55.↵
    2. Hattingen E,
    3. Raab P,
    4. Franz K, et al

    . Prognostic value of choline and creatine in WHO grade II gliomas. Neuroradiology 2008;50:759–67

    CrossRefPubMedWeb of Science
56. 56.↵
    2. Inglese M,
    3. Li BS,
    4. Rusinek H, et al

    . Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis. Magn Reson Med 2003;50:190–95

    CrossRefPubMedWeb of Science
57. 57.↵
    2. Muñoz Maniega S,
    3. Cvoro V,
    4. Armitage PA, et al

    . Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. Stroke 2008;39:2467–69

    Abstract/FREE Full Text
58. 58.↵
    2. Gasparovic C,
    3. Yeo R,
    4. Mannell M, et al

    . Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: an 1H-magnetic resonance spectroscopy study. J Neurotrauma 2009;26:1635–43

    CrossRefPubMedWeb of Science
59. 59.↵
    2. Danielsen ER,
    3. Michaelis T,
    4. Ross BD

    . Three methods of calibration in quantitative proton MR spectroscopy. J Magn Reson B 1995;106:287–91

    CrossRefPubMedWeb of Science
60. 60.↵
    2. Jansen JF,
    3. Backes WH,
    4. Nicolay K, et al

    . 1H MR spectroscopy of the brain: absolute quantification of metabolites. Radiology 2006;240:318–32

    CrossRefPubMedWeb of Science
61. 61.↵
    2. Provencher SW

    . Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672–79

    CrossRefPubMedWeb of Science
62. 62.↵
    2. Holshouser BA,
    3. Ashwal S,
    4. Luh GY, et al

    . Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children. Radiology 1997;202:487–96

    CrossRefPubMedWeb of Science
63. 63.↵
    2. Horská A,
    3. Kaufmann WE,
    4. Brant LJ, et al

    . In vivo quantitative proton MRSI study of brain development from childhood to adolescence. J Magn Reson Imaging 2002;15:137–43

    CrossRefPubMedWeb of Science
64. 64.↵
    2. Kreis R,
    3. Ernst T,
    4. Ross BD

    . Development of the human brain: in-vivo quantification of metabolite and water-content with proton magnetic-resonance spectroscopy. Magnet Reson Med 1993;30:424–37

    CrossRef
65. 65.↵
    2. Kreis R,
    3. Hofmann L,
    4. Kuhlmann B, et al

    . Brain metabolite composition during early human brain development as measured by quantitative in vivo H-1 magnetic resonance spectroscopy. Magnet Reson Med 2002;48:949–58

    CrossRef
66. 66.↵
    2. Pouwels PJW,
    3. Brockmann K,
    4. Kruse B, et al

    . Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatr Res 1999;46:474–85

    CrossRefPubMedWeb of Science
67. 67.↵
    2. Ross BD,
    3. Ernst T,
    4. Kreis R, et al

    . 1H MRS in acute traumatic brain injury. J Magn Reson Imaging 1998;8:829–40

    CrossRefPubMedWeb of Science
68. 68.↵
    2. Shutter L,
    3. Tong KA,
    4. Holshouser BA

    . Proton MRS in acute traumatic brain injury: role for glutamate/glutamine and choline for outcome prediction. J Neurotrauma 2004;21:1693–705

    CrossRefPubMedWeb of Science
69. 69.↵
    2. Cohen BA,
    3. Inglese M,
    4. Rusinek H, et al

    . Proton MR spectroscopy and MRI-volumetry in mild traumatic brain injury. AJNR Am J Neuroradiol 2007;28:907–13

    Abstract/FREE Full Text
70. 70.↵
    2. Govindaraju V,
    3. Gauger GE,
    4. Manley GT, et al

    . Volumetric proton spectroscopic imaging of mild traumatic brain injury. AJNR Am J Neuroradiol 2004;25:730–37

    Abstract/FREE Full Text
71. 71.↵
    2. Henry LC,
    3. Tremblay S,
    4. Boulanger Y, et al

    . Neurometabolic changes in the acute phase after sports concussions correlate with symptom severity. J Neurotrauma 2010;27:65–76

    CrossRefPubMedWeb of Science
72. 72.↵
    2. Henry LC,
    3. Tremblay S,
    4. Leclerc S, et al

    . Metabolic changes in concussed American football players during the acute and chronic post-injury phases. BMC Neurol 2011;11:105

    CrossRefPubMed
73. 73.↵
    2. Sarmento E,
    3. Moreira P,
    4. Brito C, et al

    . Proton spectroscopy in patients with post-traumatic headache attributed to mild head injury. Headache 2009;49:1345–52

    CrossRefPubMedWeb of Science
74. 74.↵
    2. Vagnozzi R,
    3. Signoretti S,
    4. Cristofori L, et al

    . Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients. Brain 2010;133:3232–42

    Abstract/FREE Full Text
75. 75.↵
    2. Vagnozzi R,
    3. Signoretti S,
    4. Tavazzi B, et al

    . Temporal window of metabolic brain vulnerability to concussion: a pilot 1H-magnetic resonance spectroscopic study in concussed athletes—part III. Neurosurgery 2008;62:1286–95; discussion 1295–96

    CrossRefPubMedWeb of Science
76. 76.↵
    2. Govind V,
    3. Gold S,
    4. Kaliannan K, et al

    . Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits. J Neurotrauma 2010;27:483–96

    CrossRefPubMed
77. 77.↵
    2. Kirov I,
    3. Fleysher L,
    4. Babb JS, et al

    . Characterizing ‘mild’ in traumatic brain injury with proton MR spectroscopy in the thalamus: initial findings. Brain Inj 2007;21:1147–54

    CrossRefPubMedWeb of Science
78. 78.↵
    2. Maugans TA,
    3. Farley C,
    4. Altaye M, et al

    . Pediatric sports-related concussion produces cerebral blood flow alterations. Pediatrics 2012;129:28–37

    Abstract/FREE Full Text
79. 79.↵
    2. George EO,
    3. Roys S,
    4. Sours C, et al

    . Longitudinal and prognostic evaluation of mild traumatic brain injury: a 1H-magnetic resonance spectroscopy study. J Neurotrauma 2014;31:1018–28

    CrossRefPubMed
80. 80.↵
    2. Cecil KM,
    3. Hills EC,
    4. Sandel ME, et al

    . Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients. J Neurosurg 1998;88:795–801

    CrossRefPubMedWeb of Science
81. 81.↵
    2. Cimatti M

    . Assessment of metabolic cerebral damage using proton magnetic resonance spectroscopy in mild traumatic brain injury. J Neurosurg Sci 2006;50:83–88

    PubMed
82. 82.↵
    2. Ashwal S,
    3. Holshouser B,
    4. Tong K, et al

    . Proton spectroscopy detected myoinositol in children with traumatic brain injury. Pediatr Res 2004;56:630–38

    CrossRefPubMedWeb of Science
83. 83.↵
    2. Yeo RA,
    3. Gasparovic C,
    4. Merideth F, et al

    . A longitudinal proton magnetic resonance spectroscopy study of mild traumatic brain injury. J Neurotrauma 2011;28:1–11

    CrossRefPubMedWeb of Science
84. 84.↵
    2. Brooks WM,
    3. Stidley CA,
    4. Petropoulos H, et al

    . Metabolic and cognitive response to human traumatic brain injury: a quantitative proton magnetic resonance study. J Neurotrauma 2000;17:629–40

    CrossRefPubMedWeb of Science
85. 85.↵
    2. Friedman SD,
    3. Brooks WM,
    4. Jung RE, et al

    . Quantitative proton MRS predicts outcome after traumatic brain injury. Neurology 1999;52:1384–91

    CrossRef
86. 86.↵
    2. Friedman SD,
    3. Brooks WM,
    4. Jung RE, et al

    . Proton MR spectroscopic findings correspond to neuropsychological function in traumatic brain injury. AJNR Am J Neuroradiol 1998;19:1879–85

    Abstract
87. 87.↵
    2. Aaen GS,
    3. Holshouser BA,
    4. Sheridan C, et al

    . Magnetic resonance spectroscopy predicts outcomes for children with nonaccidental trauma. Pediatrics 2010;125:295–303

    Abstract/FREE Full Text
88. 88.↵
    2. Ashwal S,
    3. Holshouser BA,
    4. Shu SK, et al

    . Predictive value of proton magnetic resonance spectroscopy in pediatric closed head injury. Pediatr Neurol 2000;23:114–25

    CrossRefPubMedWeb of Science
89. 89.↵
    2. Babikian T,
    3. Freier MC,
    4. Ashwal S, et al

    . MR spectroscopy: predicting long-term neuropsychological outcome following pediatric TBI. J Magn Reson Imaging 2006;24:801–11

    CrossRefPubMedWeb of Science
90. 90.↵
    2. Brenner T,
    3. Freier MC,
    4. Holshouser BA, et al

    . Predicting neuropsychologic outcome after traumatic brain injury in children. Pediatr Neurol 2003;28:104–14

    CrossRefPubMedWeb of Science
91. 91.↵
    2. Holshouser BA,
    3. Tong KA,
    4. Ashwal S

    . Proton MR spectroscopic imaging depicts diffuse axonal injury in children with traumatic brain injury. AJNR Am J Neuroradiol 2005;26:1276–85

    Abstract/FREE Full Text
92. 92.↵
    2. Hunter JV,
    3. Thornton RJ,
    4. Wang ZJ, et al

    . Late proton MR spectroscopy in children after traumatic brain injury: correlation with cognitive outcomes. AJNR Am J Neuroradiol 2005;26:482–88

    Abstract/FREE Full Text
93. 93.↵
    2. Makoroff KL,
    3. Cecil KM,
    4. Care M, et al

    . Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. Pediatr Radiol 2005;35:668–76

    CrossRefPubMedWeb of Science
94. 94.↵
    2. Yeo RA,
    3. Phillips JP,
    4. Jung RE, et al

    . Magnetic resonance spectroscopy detects brain injury and predicts cognitive functioning in children with brain injuries. J Neurotrauma 2006;23:1427–35

    CrossRefPubMedWeb of Science
95. 95.↵
    2. Holshouser BA,
    3. Tong KA,
    4. Ashwal S, et al

    . Prospective longitudinal proton magnetic resonance spectroscopic imaging in adult traumatic brain injury. J Magn Reson Imaging 2006;24:33–40

    CrossRefPubMedWeb of Science
96. 96.↵
    2. Garnett MR,
    3. Corkill RG,
    4. Blamire AM, et al

    . Altered cellular metabolism following traumatic brain injury: a magnetic resonance spectroscopy study. J Neurotrauma 2001;18:231–40

    CrossRefPubMedWeb of Science
97. 97.↵
    2. Hari R,
    3. Forss N

    . Magnetoencephalography in the study of human somatosensory cortical processing. Philos Trans R Soc Lond B Biol Sci 1999;354:1145–54

    Abstract/FREE Full Text
98. 98.↵
    2. Hari R,
    3. Salmelin R

    . Magnetoencephalography: from SQUIDs to neuroscience—Neuroimage 20th anniversary special edition. Neuroimage 2012;61:386–96

    CrossRefPubMedWeb of Science
99. 99.↵
    2. Hamalainen M,
    3. Hari R,
    4. Ilmoniemi RJ, et al

    . Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain. Rev Mod Phys 1993;65:413–97

    CrossRefWeb of Science
100. 100.↵
     2. Stam CJ

     . Use of magnetoencephalography (MEG) to study functional brain networks in neurodegenerative disorders. J Neurol Sci 2010;289:128–34

     CrossRefPubMedWeb of Science
101. 101.↵
     2. Tormenti M,
     3. Krieger D,
     4. Puccio AM, et al

     . Magnetoencephalographic virtual recording: a novel diagnostic tool for concussion. Neurosurg Focus 2012;33:E9

     PubMed
102. 102.↵
     2. Huang M-X,
     3. Nichols S,
     4. Robb A, et al

     . An automatic MEG low-frequency source imaging approach for detecting injuries in mild and moderate TBI patients with blast and non-blast causes. Neuroimage 2012;61:1067–82

     CrossRefPubMedWeb of Science
103. 103.↵
     2. Huang MX,
     3. Theilmann RJ,
     4. Robb A, et al

     . Integrated imaging approach with MEG and DTI to detect mild traumatic brain injury in military and civilian patients. J Neurotrauma 2009;26:1213–26

     CrossRefPubMedWeb of Science
104. 104.↵
     2. Tarapore PE,
     3. Findlay AM,
     4. Lahue SC, et al

     . Resting state magnetoencephalography functional connectivity in traumatic brain injury. J Neurosurg 2013;118:1306–16

     CrossRefPubMed
105. 105.↵
     2. Verweij BH,
     3. Muizelaar JP,
     4. Vinas FC

     . Hyperacute measurement of intracranial pressure, cerebral perfusion pressure, jugular venous oxygen saturation, and laser Doppler flowmetry, before and during removal of traumatic acute subdural hematoma. J Neurosurg 2001;95:569–72

     CrossRefPubMed
106. 106.↵
     2. Adelson PD,
     3. Clyde B,
     4. Kochanek PM, et al

     . Cerebrovascular response in infants and young children following severe traumatic brain injury: a preliminary report. Pediatr Neurosurg 1997;26:200–07

     CrossRefPubMedWeb of Science
107. 107.↵
     2. Nedd K,
     3. Sfakianakis G,
     4. Ganz W, et al

     . 99mTc-HMPAO SPECT of the brain in mild to moderate traumatic brain injury patients: compared with CT: a prospective study. Brain Inj 1993;7:469–79

     CrossRefPubMedWeb of Science
108. 108.↵
     2. Kinuya K,
     3. Kakuda K,
     4. Nobata K, et al

     . Role of brain perfusion single-photon emission tomography in traumatic head injury. Nucl Med Commun 2004;25:333–37

     CrossRefPubMed
109. 109.↵
     2. Gowda NK,
     3. Agrawal D,
     4. Bal C, et al

     . Technetium Tc-99m ethyl cysteinate dimer brain single-photon emission CT in mild traumatic brain injury: a prospective study. AJNR Am J Neuroradiol 2006;27:447–51

     Abstract/FREE Full Text
110. 110.↵
     2. Pavel D,
     3. Jobe T,
     4. Devore-Best S, et al

     . Viewing the functional consequences of traumatic brain injury by using brain SPECT. Brain Cogn 2006;60:211–13

     PubMed
111. 111.↵
     2. Shin YB,
     3. Kim SJ,
     4. Kim IJ, et al

     . Voxel-based statistical analysis of cerebral blood flow using Tc-99m ECD brain SPECT in patients with traumatic brain injury: group and individual analyses. Brain Inj 2006;20:661–67

     CrossRefPubMed
112. 112.↵
     2. Uruma G,
     3. Hashimoto K,
     4. Abo M

     . A new method for evaluation of mild traumatic brain injury with neuropsychological impairment using statistical imaging analysis for Tc-ECD SPECT. Ann Nucl Med 2013;27:187–202

     CrossRefPubMed
113. 113.↵
     2. Bavetta S,
     3. Nimmon CC,
     4. White J, et al

     . A prospective study comparing SPET with MRI and CT as prognostic indicators following severe closed head injury. Nucl Med Commun 1994;15:961–68

     CrossRefPubMed
114. 114.↵
     2. Abu-Judeh HH,
     3. Parker R,
     4. Singh M, et al

     . SPET brain perfusion imaging in mild traumatic brain injury without loss of consciousness and normal computed tomography. Nucl Med Commun 1999;20:505–10

     CrossRefPubMedWeb of Science
115. 115.↵
     2. Yamaki T,
     3. Imahori Y,
     4. Ohmori Y, et al

     . Cerebral hemodynamics and metabolism of severe diffuse brain injury measured by PET. J Nucl Med 1996;37:1166–70

     Abstract/FREE Full Text
116. 116.↵
     2. Wintermark M,
     3. van Melle G,
     4. Schnyder P, et al

     . Admission perfusion CT: prognostic value in patients with severe head trauma. Radiology 2004;232:211–20

     CrossRefPubMed
117. 117.↵
     2. Wintermark M,
     3. Chiolero R,
     4. van Melle G, et al

     . Relationship between brain perfusion computed tomography variables and cerebral perfusion pressure in severe head trauma patients. Crit Care Med 2004;32:1579–87

     CrossRefPubMedWeb of Science
118. 118.↵
     2. Wintermark M,
     3. Chiolero R,
     4. Van Melle G, et al

     . Cerebral vascular autoregulation assessed by perfusion-CT in severe head trauma patients. J Neuroradiol 2006;33:27–37

     CrossRefPubMed
119. 119.↵
     2. Metting Z,
     3. Rodiger LA,
     4. de Jong BM, et al

     . Acute cerebral perfusion CT abnormalities associated with posttraumatic amnesia in mild head injury. J Neurotrauma 2010;27:2183–89

     CrossRefPubMed
120. 120.↵
     2. Soustiel JF,
     3. Mahamid E,
     4. Goldsher D, et al

     . Perfusion-CT for early assessment of traumatic cerebral contusions. Neuroradiology 2008;50:189–96

     CrossRefPubMed
121. 121.↵
     2. Garnett MR,
     3. Blamire AM,
     4. Corkill RG, et al

     . Abnormal cerebral blood volume in regions of contused and normal appearing brain following traumatic brain injury using perfusion magnetic resonance imaging. J Neurotrauma 2001;18:585–93

     CrossRefPubMed
122. 122.↵
     2. Liu W,
     3. Wang B,
     4. Wolfowitz R, et al

     . Perfusion deficits in patients with mild traumatic brain injury characterized by dynamic susceptibility contrast MRI. NMR Biomed 2013;26:651–63

     PubMed
123. 123.↵
     2. Ge YL,
     3. Patel MB,
     4. Chen Q, et al

     . Assessment of thalamic perfusion in patients with mild traumatic brain injury by true FISP arterial spin labelling MR imaging at 3T. Brain Inj 2009;23:666–74

     CrossRefPubMedWeb of Science
124. 124.↵
     2. Kim J,
     3. Whyte J,
     4. Patel S, et al

     . Resting cerebral blood flow alterations in chronic traumatic brain injury: an arterial spin labeling perfusion FMRI study. J Neurotrauma 2010;27:1399–411

     CrossRefPubMedWeb of Science
125. 125.↵
     2. Peters AM,
     3. Gunasekera RD,
     4. Henderson BL, et al

     . Noninvasive measurement of blood flow and extraction fraction. Nucl Med Commun 1987;8:823–37

     CrossRefPubMedWeb of Science
126. 126.↵
     2. Wintermark M,
     3. Thiran JP,
     4. Maeder P, et al

     . Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study. AJNR Am J Neuroradiol 2001;22:905–14

     Abstract/FREE Full Text
127. 127.↵
     2. Kudo K,
     3. Terae S,
     4. Katoh C, et al

     . Quantitative cerebral blood flow measurement with dynamic perfusion CT using the vascular-pixel elimination method: comparison with (H2O)-O-15 positron emission tomography. AJNR Am J Neuroradiol 2003;24:419–26

     Abstract/FREE Full Text
128. 128.↵
     2. Latchaw RE,
     3. Yonas H,
     4. Pentheny SL, et al

     . Adverse reactions to xenon-enhanced CT cerebral blood flow determination. Radiology 1987;163:251–54

     CrossRefPubMedWeb of Science
129. 129.↵
     2. Wintermark M,
     3. Reichhart M,
     4. Thiran JP, et al

     . Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients. Ann Neurol 2002;51:417–32

     CrossRefPubMedWeb of Science
130. 130.↵
     2. Wintermark M,
     3. Reichhart M,
     4. Cuisenaire O, et al

     . Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients. Stroke 2002;33:2025–31

     Abstract/FREE Full Text
131. 131.↵
     2. Amorim RL,
     3. Bor-Seng-Shu E,
     4. Gattás GS, et al

     . Decompressive craniectomy and cerebral blood flow regulation in head injured patients: a case studied by perfusion CT. J Neuroradiol 2012;39:346–49

     CrossRefPubMed
132. 132.↵
     2. Metting Z,
     3. Cerliani L,
     4. Rodiger LA, et al

     . Pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging. PLoS One 2013;8:e64461

     CrossRefPubMed
133. 133.↵
     2. Grossman EJ,
     3. Jensen JH,
     4. Babb JS, et al

     . Cognitive impairment in mild traumatic brain injury: a longitudinal diffusional kurtosis and perfusion imaging study. AJNR Am J Neuroradiol 2013;34:951–57, S1–3

     Abstract/FREE Full Text
134. 134.↵
     2. Stamatakis EA,
     3. Wilson JTL,
     4. Hadley DM, et al

     . SPECT imaging in head injury interpreted with statistical parametric mapping. J Nucl Med 2002;43:476–83

     Abstract/FREE Full Text
135. 135.↵
     2. Lorberboym M,
     3. Lampl Y,
     4. Gerzon I, et al

     . Brain SPECT evaluation of amnestic ED patients after mild head trauma. Am J Emerg Med 2002;20:310–13

     CrossRefPubMedWeb of Science
136. 136.↵
     2. Lewine JD,
     3. Davis JT,
     4. Bigler ED, et al

     . Objective documentation of traumatic brain injury subsequent to mild head trauma: multimodal brain imaging with MEG, SPECT, and MRI. J Head Trauma Rehabil 2007;22:141–55

     CrossRefPubMedWeb of Science
137. 137.↵
     2. Chen SHA,
     3. Kareken DA,
     4. Fastenau PS, et al

     . A study of persistent post-concussion symptoms in mild head trauma using positron emission tomography. J Neurol Neurosurg Psychiatry 2003;74:326–32

     Abstract/FREE Full Text
138. 138.↵
     2. Peskind ER,
     3. Petrie EC,
     4. Cross DJ, et al

     . Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war veterans with persistent post-concussive symptoms. Neuroimage 2011;54(suppl 1):S76–82

     CrossRefPubMedWeb of Science
139. 139.↵
     2. Byrnes KR,
     3. Wilson CM,
     4. Brabazon F, et al

     . FDG-PET imaging in mild traumatic brain injury: a critical review. Front Neuroenergetics 2014;5:13

     PubMed
140. 140.↵
     2. Raji CA,
     3. Tarzwell R,
     4. Pavel D, et al

     . Clinical utility of SPECT neuroimaging in the diagnosis and treatment of traumatic brain injury: a systematic review. PLoS One 2014;9:e91088

     CrossRefPubMed
141. 141.↵
     2. Bigler ED

     . Neuroimaging biomarkers in mild traumatic brain injury (mTBI). Neuropsychol Rev 2013;23:169–209

     CrossRefPubMed
142. 142.↵
     2. Hong YT,
     3. Veenith T,
     4. Dewar D, et al

     . Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury. JAMA Neurol 2014;71:23–31

     CrossRefPubMed
143. 143.↵
     2. Small GW,
     3. Kepe V,
     4. Siddarth P, et al

     . PET scanning of brain tau in retired National Football League players: preliminary findings. Am J Geriatr Psychiatry 2013;21:138–44

     CrossRefPubMedWeb of Science
144. 144.↵
     2. Stein TD,
     3. Alvarez VE,
     4. McKee AC

     . Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimers Res Ther 2014;6:4

     CrossRefPubMed
145. 145.↵
     2. Gavett BE,
     3. Stern RA,
     4. McKee AC

     . Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma. Clin Sports Med 2011;30:179–88, xi

     CrossRefPubMedWeb of Science
146. 146.↵
     2. Shively S,
     3. Scher AI,
     4. Perl DP, et al

     . Dementia resulting from traumatic brain injury: what is the pathology? Arch Neurol 2012;69:1245–51

     PubMed
147. 147.↵
     2. McKinney A,
     3. Ott F,
     4. Short J, et al

     . Angiographic frequency of blunt cerebrovascular injury in patients with carotid canal or vertebral foramen fractures on multidetector CT. Eur J Radiol 2007;62:385–93

     CrossRefPubMed
148. 148.↵
     2. Franz RW,
     3. Willette PA,
     4. Wood MJ, et al

     . A systematic review and meta-analysis of diagnostic screening criteria for blunt cerebrovascular injuries. J Am Coll Surg 2012;214:313–27

     CrossRefPubMed
149. 149.↵
     2. Biffl WL,
     3. Moore EE,
     4. Offner PJ, et al

     . Blunt carotid arterial injuries: implications of a new grading scale. J Trauma 1999;47:845–53

     CrossRefPubMedWeb of Science
150. 150.↵
     2. Löhrer L,
     3. Vieth V,
     4. Nassenstein I, et al

     . Blunt cerebrovascular injuries in acute trauma care: a screening protocol. Eur Spine J 2012;21:837–43

     CrossRefPubMed
151. 151.↵
     2. Cothren CC,
     3. Moore EE,
     4. Ray CE Jr., et al

     . Cervical spine fracture patterns mandating screening to rule out blunt cerebrovascular injury. Surgery 2007;141:76–82

     CrossRefPubMedWeb of Science
152. 152.↵
     2. Kopelman TR,
     3. Leeds S,
     4. Berardoni NE, et al

     . Incidence of blunt cerebrovascular injury in low-risk cervical spine fractures. Am J Surg 2011;202:684–88; discussion 688–89

     CrossRefPubMed
153. 153.↵
     2. Burlew CC,
     3. Biffl WL,
     4. Moore EE, et al

     . Blunt cerebrovascular injuries: redefining screening criteria in the era of noninvasive diagnosis. J Trauma Acute Care Surg 2012;72:330–35; discussion 336–37, quiz 539

     PubMed
154. 154.↵
     2. Berne JD,
     3. Cook A,
     4. Rowe SA, et al

     . A multivariate logistic regression analysis of risk factors for blunt cerebrovascular injury. J Vasc Surg 2010;51:57–64

     CrossRefPubMedWeb of Science
155. 155.↵
     2. Chokshi FH,
     3. Munera F,
     4. Rivas LA, et al

     . 64-MDCT angiography of blunt vascular injuries of the neck. AJR Am J Roentgenol 2011;196:W309–15

     CrossRefPubMed
156. 156.↵
     2. Desai NK,
     3. Kang J,
     4. Chokshi FH

     . Screening CT angiography for pediatric blunt cerebrovascular injury with emphasis on the cervical “seatbelt sign.” AJNR Am J Neuroradiol 2014;35:1836–40

     Abstract/FREE Full Text
157. 157.↵
     2. Dhillon RS,
     3. Barrios C,
     4. Lau C, et al

     . Seatbelt sign as an indication for four-vessel computed tomography angiogram of the neck to diagnose blunt carotid artery and other cervical vascular injuries. Am Surg 2013;79:1001–04

     PubMed
158. 158.↵
     2. Fleck SK,
     3. Langner S,
     4. Baldauf J, et al

     . Blunt craniocervical artery injury in cervical spine lesions: the value of CT angiography. Acta Neurochir (Wien) 2010;152:1679–86

     CrossRefPubMed
159. 159.↵
     2. Liang T,
     3. McLaughlin PD,
     4. Louis L, et al

     . Review of multidetector computed tomography angiography as a screening modality in the assessment of blunt vascular neck injuries. Can Assoc Radiol J 2013;64:130–39

     CrossRefPubMed
160. 160.↵
     2. Patterson BO,
     3. Holt PJ,
     4. Cleanthis M, et al

     . Imaging vascular trauma. Br J Surg 2012;99:494–505

     CrossRefPubMed
161. 161.↵
     2. Sliker CW

     . Blunt cerebrovascular injuries: imaging with multidetector CT angiography. Radiographics 2008;28:1689–708; discussion 1709–10

     CrossRefPubMedWeb of Science
162. 162.↵
     2. Shiroff AM,
     3. Gale SC,
     4. Martin ND, et al

     . Penetrating neck trauma: a review of management strategies and discussion of the ‘No Zone’ approach. Am Surg 2013;79:23–29

     PubMed
163. 163.↵
     2. Kansagra AP,
     3. Cooke DL,
     4. English JD, et al

     . Current trends in endovascular management of traumatic cerebrovascular injury. J Neurointerv Surg 2014;6:47–50

     Abstract/FREE Full Text
164. 164.↵
     2. Hassan AE,
     3. Zacharatos H,
     4. Souslian F, et al

     . Long-term clinical and angiographic outcomes in patients with cervico-cranial dissections treated with stent placement: a meta-analysis of case series. J Neurotrauma 2012;29:1342–53

     CrossRefPubMedWeb of Science