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Figures
- Fig 1.
Visual assessment of nigrosome 1 in MR imaging. On the oblique axial MEDIC imaging, the evaluation of nigrosome 1 (arrows) was performed on 3 sections: an upper section at the lower tip of the red nucleus and the 2 successive sections (A). The oblique coronal MEDIC imaging was also assessed on 3 sections: an anterior section at the anterior tip of the red nucleus and the 2 consecutive sections (B). In this particular 71-year-old woman, the nigrosome 1 appears normal on both sides.
- Fig 2.
Degree of abnormality on MR imaging. Possibly abnormal and definitely abnormal were rated in the left (arrows) and right (open arrows) nigrosome 1, respectively (A). Similar asymmetry was observed on 18F-FP-CIT PET. This 53-year-old woman has H&Y stage 2 and UPDRS Part III (motor score) of 4 and 1 on the left and right, respectively, which is in concordance with asymmetry on both MR imaging and 18F-FP-CIT PET.
- Fig 3.
False-positive on MR imaging. In this 64-year-old healthy female subject, both reviewers interpreted the left nigrosome (arrows) was as normal, whereas they called the right one (broken arrows) abnormal.
- Fig 4.
Asymmetry on MR imaging but not on 18F-FP-CIT in a 78-year-old woman with H&Y stage 2 and UPDRS of 4 and 2 on the right and left shows that the left nigrosome 1 is more affected (arrows) than the right one (open arrows) (A), whereas 18F-FP-CIT PET shows relatively symmetric findings (B).
Tables
IPD (n = 24) Healthy Control (n = 13) P Value Age (yr) 63.6 ± 10.97 61.6 ± 12.29 .620 Female sex (%) 10 (41.7%) 9 (69.2%) .170 MMSE 27.5 (25.0–29.0) 29.0 (28.0–29.5) .036 Onset age (yr) 62.4 ± 11.59 – Disease duration (mo) 9.0 (3.0–12.0) – H&Y scale (1/1.5/2) 2/2/20 – UPDRS I 1.0 (0–2.0) – UPDRS II 6.75 ± 2.85 – UPDRS III 13.5 ± 6.19 – Note:—MMSE indicates Mini-Mental State Examination; UPDRS, Unified Parkinson Disease Rating Scale, –, not applicable.
↵a Data are presented as mean ± SD for normally distributed variables and median (interquartile ranges) for non-normally distributed variables. The χ2 test with Yates continuity correction was used.
Reviewer 1 Reviewer 2 Right Left Right Left Normal (No.) 10 13 12 11 Possibly abnormal (No.) 7 5 2 3 Definitely abnormal (No.) 20 19 23 23
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