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Research ArticleNeurointervention
Open Access

A Comparison of 4D DSA with 2D and 3D DSA in the Analysis of Normal Vascular Structures in a Canine Model

C. Sandoval-Garcia, K. Royalty, B. Aagaard-Kienitz, S. Schafer, P. Yang and C. Strother
American Journal of Neuroradiology October 2015, 36 (10) 1959-1963; DOI: https://doi.org/10.3174/ajnr.A4359
C. Sandoval-Garcia
aFrom the Departments of Neurological Surgery (C.S.-G., B.A.-K.)
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K. Royalty
bBiomedical Engineering (K.R)
dSiemens (K.R., S.S.), Hoffman Estates, Illinois
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B. Aagaard-Kienitz
aFrom the Departments of Neurological Surgery (C.S.-G., B.A.-K.)
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S. Schafer
dSiemens (K.R., S.S.), Hoffman Estates, Illinois
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P. Yang
cRadiology (P.Y., C.S.), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
eDepartment of Neurosurgery (P.Y.), Changhai Hospital, Second Military Medical University, Shanghai, China.
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C. Strother
cRadiology (P.Y., C.S.), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
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Article Figures & Data

Figures

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  • Fig 1.
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    Fig 1.

    Example of the vasculature on anteroposterior 2D DSA projections for each catheter position: proximal (A), middle (B), and distal (C). These show the decrease in the vascular complexity as the injection site is moved from proximal to most distal. The magnification factor for the images increases, moving from proximal to most distal.

  • Fig 2.
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    Fig 2.

    Illustration of 4D DSA reconstruction. No x-ray delay between contrast injection and rotational image acquisition results in contrast flow or inflow being visible in the rotational projections (A–C). Through a 2-step reconstruction process, this flow information is encoded into the 3D DSA for every projection, effectively creating a 4D DSA. This allows viewing of the contrast bolus passage at any desired angle at any time during the bolus passage. D–F, View of the bolus passage at 3 projection angles at 3 different time points. G–I, View of the bolus passage at 3 angles not present in the projections, again at 3 different time points. The figures correspond to sample angle projections selected to match the 2D acquisitions, even though once 4D images are reconstructed, views are available from any angle.

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    Fig 3.

    A–C, Example of the pictorial reference form provided to the image reviewers identifying the vascular segments to be evaluated: proximal (A), middle (B), and distal (C) catheter positions on anteroposterior projections. D, Evaluation form and scales used for scoring of the images.

Tables

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    Table 1:

    Injection parameters used for the various acquisitions

    ProximalMiddleDistal
    2D DSA3D DSA4D DSA2D DSA3D DSA4D DSA2D DSA3D DSA4D DSA
    Contrast volume (mL)8–920208–911118–989
    Concentration (%)505050505050505050
    Flow rate (mL/s)HI33HI1.5–2.51.5–2.5HI1–1.51–1.5
    Injection duration (s)HI6.66.6HI66HI7.37.3
    Injection delay (s)100100100
    X-ray delay (s)010010010
    • Note:—HI indicates hand injection.

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    Table 2:

    Raw data from each of the 2 observers for all 44 vessel segmentsa

    Reviewer 1Reviewer 2
    2D3D4DPreferred2D3D4DPreferred
    3444D2444D
    3344D4444D
    4244D0344D
    4242D3444D
    4244D2344D
    4244D3344D
    4342D3444D
    4332D4234D
    4244D4334D
    4444D3344D
    4444D2344D
    4444D2344D
    4332D4444D
    4342D2444D
    4344D2444D
    4332D4444D
    4423D4433D
    4344D4433D
    4242D4444D
    4134D4444D
    4342D4444D
    4442D4444D
    4342D4344D
    4344D4444D
    4442D4444D
    4342D4332D
    3222D2012D
    4444D1444D
    4244D2244D
    4344D3344D
    4444D4344D
    4444D3244D
    4344D2244D
    4444D4444D
    4344D3344D
    3344D4144D
    4342D3444D
    4244D3244D
    4442D4444D
    4342D4444D
    4444D3444D
    4344D3344D
    3442D3424D
    4432D4444D
    • ↵a The first 3 columns show the rating for each of the 3 modalities as described in the “Materials and Methods” and the scoring form (Fig 3B). The last column shows the preferred modality.

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American Journal of Neuroradiology: 36 (10)
American Journal of Neuroradiology
Vol. 36, Issue 10
1 Oct 2015
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Cite this article
C. Sandoval-Garcia, K. Royalty, B. Aagaard-Kienitz, S. Schafer, P. Yang, C. Strother
A Comparison of 4D DSA with 2D and 3D DSA in the Analysis of Normal Vascular Structures in a Canine Model
American Journal of Neuroradiology Oct 2015, 36 (10) 1959-1963; DOI: 10.3174/ajnr.A4359

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A Comparison of 4D DSA with 2D and 3D DSA in the Analysis of Normal Vascular Structures in a Canine Model
C. Sandoval-Garcia, K. Royalty, B. Aagaard-Kienitz, S. Schafer, P. Yang, C. Strother
American Journal of Neuroradiology Oct 2015, 36 (10) 1959-1963; DOI: 10.3174/ajnr.A4359
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  • Application of Time-Resolved 3D Digital Subtraction Angiography to Plan Cerebral Arteriovenous Malformation Radiosurgery
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