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Research ArticleNeurointervention

Additional Value of Intra-Aneurysmal Hemodynamics in Discriminating Ruptured versus Unruptured Intracranial Aneurysms

J.J. Schneiders, H.A. Marquering, P. van Ooij, R. van den Berg, A.J. Nederveen, D. Verbaan, W.P. Vandertop, M. Pourquie, G.J.E. Rinkel, E. vanBavel and C.B.L.M. Majoie
American Journal of Neuroradiology October 2015, 36 (10) 1920-1926; DOI: https://doi.org/10.3174/ajnr.A4397
J.J. Schneiders
aFrom the Departments of Radiology (J.J.S., H.A.M., P.v.O., R.v.d.B., A.J.N., C.B.L.M.M.)
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H.A. Marquering
aFrom the Departments of Radiology (J.J.S., H.A.M., P.v.O., R.v.d.B., A.J.N., C.B.L.M.M.)
bBiomedical Engineering and Physics (H.A.M., E.V.)
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P. van Ooij
aFrom the Departments of Radiology (J.J.S., H.A.M., P.v.O., R.v.d.B., A.J.N., C.B.L.M.M.)
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R. van den Berg
aFrom the Departments of Radiology (J.J.S., H.A.M., P.v.O., R.v.d.B., A.J.N., C.B.L.M.M.)
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A.J. Nederveen
aFrom the Departments of Radiology (J.J.S., H.A.M., P.v.O., R.v.d.B., A.J.N., C.B.L.M.M.)
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D. Verbaan
cNeurosurgery (D.V., W.P.V.), Academic Medical Center, Amsterdam, the Netherlands
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W.P. Vandertop
cNeurosurgery (D.V., W.P.V.), Academic Medical Center, Amsterdam, the Netherlands
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M. Pourquie
dDepartment of Aero- and Hydrodynamics (M.P.), Delft University of Technology, Delft, the Netherlands
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G.J.E. Rinkel
eDepartment of Neurology and Neurosurgery (G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, the Netherlands.
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E. vanBavel
bBiomedical Engineering and Physics (H.A.M., E.V.)
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C.B.L.M. Majoie
aFrom the Departments of Radiology (J.J.S., H.A.M., P.v.O., R.v.d.B., A.J.N., C.B.L.M.M.)
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    Fig 1.

    Flow chart of patient and aneurysm inclusion.

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    Fig 2.

    Intra-aneurysmal hemodynamics in 3 typical aneurysms. Diastole is depicted in the top row; systole, in the bottom row. The columns represent: A, Isosurface of the velocity. B, 3D streamlines colored by velocity magnitude. C, 2D slice of the velocity magnitude. D, Wall shear stress distribution displayed on 3D geometry. The rows represent cases 1–3. Case 1: Ruptured anterior communicating artery aneurysm with a concentrated inflow jet (A and C) and a stable-simple flow pattern: single vortex that is stable throughout the cardiac cycle (B). The impingement zone is located at the body (D). Case 2: Unruptured posterior communicating artery aneurysm with a concentrated inflow jet (A and C) and a stable-complex flow pattern: multiple flow structures that remain stable throughout the cardiac cycle (B). The impingement zone is located at the dome (D) and 2 daughter sacs (D). Case 3: Ruptured anterior communicating artery aneurysm with a concentrated inflow jet (A and C) and an unstable-simple flow pattern: a single flow structure that is unstable throughout the cardiac cycle. The primary direction of flow is different between systole and diastole (B). The impingement zone is located at the neck (D) and 2 daughter sacs (D).

Tables

  • Figures
  • Location, aneurysm type, and rupture status of 117 aneurysms (101 patients)

    LocationaNo. of CasesTotal (n = 117)Bifurcation (n = 90)Sidewall (n = 27)
    UnrupturedRupturedUnrupturedRupturedUnrupturedRuptured
    High-risk location
        PcomA12 (10%)483315
        BA11 (9%)838201
        VA1 (1%)010001
        ACA8 (7%)352510
        AcomA28 (24%)72172001
        Subtotal60 (51%)2238203028
    Low-risk location
        MCA36 (31%)27923940
        ICA21 (18%)13835103
        Subtotal57 (49%)40172614143
    Total117 (100%)625546441611
    • Note:—AcomA indicates anterior communicating artery; PcomA, posterior communicating artery; VA, vertebral artery.

    • ↵a ICA includes the internal carotid, ophthalmic, anterior choroidal arteries and the carotid tip; ACA includes the anterior cerebral and pericallosal arteries; BA includes the basilar, PICA, and superior cerebellar arteries.

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American Journal of Neuroradiology: 36 (10)
American Journal of Neuroradiology
Vol. 36, Issue 10
1 Oct 2015
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Cite this article
J.J. Schneiders, H.A. Marquering, P. van Ooij, R. van den Berg, A.J. Nederveen, D. Verbaan, W.P. Vandertop, M. Pourquie, G.J.E. Rinkel, E. vanBavel, C.B.L.M. Majoie
Additional Value of Intra-Aneurysmal Hemodynamics in Discriminating Ruptured versus Unruptured Intracranial Aneurysms
American Journal of Neuroradiology Oct 2015, 36 (10) 1920-1926; DOI: 10.3174/ajnr.A4397

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Additional Value of Intra-Aneurysmal Hemodynamics in Discriminating Ruptured versus Unruptured Intracranial Aneurysms
J.J. Schneiders, H.A. Marquering, P. van Ooij, R. van den Berg, A.J. Nederveen, D. Verbaan, W.P. Vandertop, M. Pourquie, G.J.E. Rinkel, E. vanBavel, C.B.L.M. Majoie
American Journal of Neuroradiology Oct 2015, 36 (10) 1920-1926; DOI: 10.3174/ajnr.A4397
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