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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Cytotoxic Edema in Posterior Reversible Encephalopathy Syndrome: Correlation of MRI Features with Serum Albumin Levels

B. Gao, B.X. Yu, R.S. Li, G. Zhang, H.Z. Xie, F.L. Liu and C. Lv
American Journal of Neuroradiology October 2015, 36 (10) 1884-1889; DOI: https://doi.org/10.3174/ajnr.A4379
B. Gao
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
bDepartment of Radiology (B.G.), Zhongda Hospital, Southeast University, Nanjing, China
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B.X. Yu
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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R.S. Li
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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G. Zhang
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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H.Z. Xie
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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F.L. Liu
aFrom the Department of Radiology (B.G., B.X.Y., R.S.L., G.Z., H.Z.X., F.L.L.), Yantai Yuhuangding Hospital, Qingdao University, Shandong Province, China
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C. Lv
cDepartment of Neurology (C.L.), Yantai City Yantaishan Hospital and Yantai Sino-France Friendship Hospital, Shandong Province, China.
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    Fig 1.

    Comparison of serum albumin levels between patients with PRES with cytotoxic edema and those only with vasogenic edema. A, A 26-year-old pregnant woman presented with eclampsia, with a serum albumin level of 37 mg/dL. Hyperintense abnormalities are found in bilateral frontoparietal lobes on FLAIR (left), hyperintense on DWI (middle) and hypointense on ADC (right), and are also noted in the right parietal lobe, indicating cytotoxic edema. B, A 22-year-old woman with systemic vasculitis with a serum albumin level of 34.2 mg/dL and blood pressure of 175/110 mm Hg at onset. Symmetric hyperintensities are found in the bilateral frontoparietal lobes on FLAIR (left), isointense on DWI (middle) and hyperintense on ADC (right), indicating vasogenic edema.

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    Fig 2.

    Comparison of the scores of brain edema between patients with PRES with cytotoxic edema and those only with vasogenic edema. A, A 25-year-old woman with eclampsia and seizures after cesarean delivery. FLAIR image shows symmetric confluent heterogeneous hyperintensities in the bilateral, frontal, and parietal lobes (left) with a scale score 3 of edema severity and marked hyperintensity in the adjacent cortex on DWI (middle), with hypointensity on the ADC map (right), indicating cytotoxic edema. B, A 27-year-old man with hypertension and nephritis had headache with blood pressure of 180/120 mm. Symmetric hyperintensities are found in the bilateral occipital lobes on FLAIR (left) with a scale score 1 of edema severity, isointense on DWI (middle) and hyperintense on ADC (right), indicating vasogenic edema.

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  • Comparison of clinical parameters in patients with present and absent cytotoxic edema

    ParametersCytotoxic Edema Present (n = 26)Cytotoxic Edema Absent (n = 53)P Value
    Age (y)34.51 ± 11.4233.21 ± 15.01.74
    Sex11/1521/32.077
    Causea4/335/46.19
    MAP (mm Hg)138.51 ± 28.63124.83 ± 30.22.13
    ALB (mg/mL)522.00 ± 241.47388.00 ± 191.18.98
    ALB decreased ratio22/2645/53.12
    SBE20.36 ± 11.4310.24 ± 7.20.003b
    • Note:—MAP indicates mean arterial pressure; ALB, albumin; SBE, score of brain edema.

    • ↵a Percentage of patients with eclampsia or pre-eclampsia.

    • ↵b Significant.

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American Journal of Neuroradiology: 36 (10)
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Cite this article
B. Gao, B.X. Yu, R.S. Li, G. Zhang, H.Z. Xie, F.L. Liu, C. Lv
Cytotoxic Edema in Posterior Reversible Encephalopathy Syndrome: Correlation of MRI Features with Serum Albumin Levels
American Journal of Neuroradiology Oct 2015, 36 (10) 1884-1889; DOI: 10.3174/ajnr.A4379

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Cytotoxic Edema in Posterior Reversible Encephalopathy Syndrome: Correlation of MRI Features with Serum Albumin Levels
B. Gao, B.X. Yu, R.S. Li, G. Zhang, H.Z. Xie, F.L. Liu, C. Lv
American Journal of Neuroradiology Oct 2015, 36 (10) 1884-1889; DOI: 10.3174/ajnr.A4379
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