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Research ArticleAdult Brain

CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients

I.A. Meyer, M. Wintermark, J.-F. Démonet and P. Michel
American Journal of Neuroradiology October 2015, 36 (10) 1830-1833; DOI: https://doi.org/10.3174/ajnr.A4370
I.A. Meyer
aFrom the Neurology Service (I.A.M., P.M.)
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M. Wintermark
cDepartment of Radiology (M.W.), Stanford University School of Medicine, Stanford, California.
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J.-F. Démonet
bthe Leenaards Memory Center (J.-F.D.), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
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P. Michel
aFrom the Neurology Service (I.A.M., P.M.)
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    Fig 1.

    Upper row: CTP shows abnormalities in the lentiform nuclei bilaterally (white arrows) in a 43-year-old patient with transient global amnesia at 2.5 hours from symptom onset. Bottom row: PWI shows abnormalities (white arrows) at 4.0 hours from symptom onset. NEI indicates negative enhancement integral (CBV equivalent); MSD, maximum slope of decrease (CBF equivalent); MTE, mean time to enhance (MTT equivalent).

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    Fig 2.

    Acute CTP and subacute DWI in 2 female patients presenting with classic TGA symptoms. All CTP map findings for both patients were normal, while punctate DWI lesions were detected in the lateral hippocampus, bilaterally at 45 hours (62-year-old patient, upper row), and unilaterally at 64 hours (61-year-old patient, lower row) after symptom onset, respectively.

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  • Patient characteristics and diagnostic tests performeda

    Characteristic
    Women (%)18 (60.0)
    Age (yr)64 (57–70)
    Cerebrovascular risk factor, none (%)13 (43.3)
        Current smokers (%)b2 (6.7)
        Hypertension, treated (%)10 (33.3)
        Hyperlipidemia, treated (%)5 (16.7)
        Impaired glucose tolerance (%)1 (3.3)
        History of atrial fibrillation (%)5 (16.7)
        High-risk alcohol consumption (%)2 (6.7)
        Previous cerebrovascular event (%)3 (10.0)
    Approximate duration of anterograde amnesia (hr)12 (4–17)
    Previous episode of TGA (%)3 (10.0)
    Documented triggering event, any (%)16 (53.3)
         Emotional (%)9 (30.0)
         Physical (%)7 (23.3)
    CTP
        Delay from TGA onset (hr)6 (4–10)
        Anterograde amnesia still present (%)20 (66.7)
        Hippocampi well-visualized on CTP (%)14 (46.7)
    EEG (%)23 (76.7)
        Delay from onset (hr)21 (7–27)
        Abnormalities (all nonspecific)10 (33.3)
    DWI (%)10 (33.3)
        Delay from onset (days)2 (1–3)
        Punctate hippocampal lesions (%)2 (6.7)
    • Note:—EEG indicates electroencephalography.

    • ↵a Data are shown as No. (%) for categoric variables and median ± interquartile range for continuous variables.

    • ↵b Four additional patients (13.3%) did smoke in the past.

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American Journal of Neuroradiology: 36 (10)
American Journal of Neuroradiology
Vol. 36, Issue 10
1 Oct 2015
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Cite this article
I.A. Meyer, M. Wintermark, J.-F. Démonet, P. Michel
CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients
American Journal of Neuroradiology Oct 2015, 36 (10) 1830-1833; DOI: 10.3174/ajnr.A4370

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CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients
I.A. Meyer, M. Wintermark, J.-F. Démonet, P. Michel
American Journal of Neuroradiology Oct 2015, 36 (10) 1830-1833; DOI: 10.3174/ajnr.A4370
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