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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleResearch Perspectives
Open Access

Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline

C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga and M.W. Vernooij
American Journal of Neuroradiology October 2015, 36 (10) 1803-1809; DOI: https://doi.org/10.3174/ajnr.A4409
C.A. Raji
aFrom the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.)
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H. Eyre
bPsychiatry (H.E., G.S.)
eDiscipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia
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S.H. Wei
aFrom the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.)
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D.E. Bredesen
cNeurology (D.E.B.)
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S. Moylan
fSchool of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia
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M. Law
gDepartment of Radiology (M.L.)
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G. Small
bPsychiatry (H.E., G.S.)
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P.M. Thompson
hLaboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California
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R.M. Friedlander
iDepartment of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania
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D.H. Silverman
dNuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California
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B.T. Baune
eDiscipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia
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T.A. Hoang
aFrom the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.)
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N. Salamon
aFrom the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.)
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A.W. Toga
hLaboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California
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M.W. Vernooij
jDepartments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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REFERENCES

  1. 1.↵
    1. Erickson KI,
    2. Creswell JD,
    3. Verstynen TD, et al
    . Health neuroscience: defining a new field. Curr Dir Psychol Sci 2014;23:446–53
    Abstract/FREE Full Text
  2. 2.↵
    United Nations, Department of Economic and Social Affairs, Population Division. World Population Ageing 2013. ST/ESA/SER.A/348. New York: United Nations; 2013
  3. 3.↵
    1. Prince M,
    2. Prina M,
    3. Guerchet M
    ; Alzheimer's Disease International. World Alzheimer Report 2013: Journey of Caring—An Analysis of Long-Term Care for Dementia. London: Alzheimer's Disease International; 2013
  4. 4.↵
    1. Selkoe DJ
    . Preventing Alzheimer's disease. Science 2012;337:1488–92
    Abstract/FREE Full Text
  5. 5.↵
    1. Barnes DE,
    2. Yaffe K
    . The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 2011;10:819–28
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Eyre HA,
    2. Baune BT
    . Assessing for unique immunomodulatory and neuroplastic profiles of physical activity subtypes: a focus on psychiatric disorders. Brain Behav Immun 2014;39:42–55
    CrossRefPubMed
  7. 7.↵
    1. Varteresian T,
    2. Lavretsky H
    . Natural products and supplements for geriatric depression and cognitive disorders: an evaluation of the research. Curr Psychiatry Rep 2014;16:456
    CrossRefPubMed
  8. 8.↵
    1. Wells RE,
    2. Kerr CE,
    3. Wolkin J, et al
    . Meditation for adults with mild cognitive impairment: a pilot randomized trial. J Am Geriatr Soc 2013;61:642–45
    CrossRefPubMed
  9. 9.↵
    1. Coogan AN,
    2. Schutová B,
    3. Husung S, et al
    . The circadian system in Alzheimer's disease: disturbances, mechanisms, and opportunities. Biol Psychiatry 2013;74:333–39
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Di Marco LY,
    2. Marzo A,
    3. Muñoz-Ruiz M, et al
    . Modifiable lifestyle factors in dementia: a systematic review of longitudinal observational cohort studies. J Alzheimers Dis 2014;42:119–35
    PubMed
  11. 11.↵
    1. Hua X,
    2. Leow AD,
    3. Parikshak N, et al
    ; Alzheimer's Disease Neuroimaging Initiative. Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects. Neuroimage 2008;43:458–69
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Mueller SG,
    2. Weiner MW,
    3. Thal LJ, et al
    . The Alzheimer's Disease Neuroimaging Initiative. Neuroimaging Clin N Am 2005;15:869–77, xi–xii
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. DeCarli C,
    2. Mungas D,
    3. Harvey D, et al
    . Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia. Neurology 2004;63:220–27
    CrossRefPubMed
  14. 14.↵
    1. Morra JH,
    2. Tu Z,
    3. Apostolova LG, et al
    ; Alzheimer's Disease Neuroimaging Initiative. Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Neuroimage 2009;45:S3–15
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Raji CA,
    2. Erickson KI,
    3. Lopez OL, et al
    . Regular fish consumption and age-related brain gray matter loss. Am J Prev Med 2014;47:444–51
    CrossRefPubMed
  16. 16.↵
    1. Ho AJ,
    2. Raji CA,
    3. Becker JT, et al
    . The effects of physical activity, education, and body mass index on the aging brain. Hum Brain Mapp 2011;32:1371–82
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Beydoun MA,
    2. Beydoun HA,
    3. Wang Y
    . Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev 2008;9:204–18
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Raji CA,
    2. Ho AJ,
    3. Parikshak NN, et al
    . Brain structure and obesity. Hum Brain Mapp 2010;31:353–64
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Moylan S,
    2. Berk M,
    3. Dean OM, et al
    . Oxidative & nitrosative stress in depression: why so much stress? Neurosci Biobehav Rev 2014;45:46–62
    CrossRefPubMed
  20. 20.↵
    1. Yaffe K,
    2. Haan M,
    3. Blackwell T, et al
    . Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study. J Am Geriatr Soc 2007;55:758–62
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Poirier P,
    2. Després JP,
    3. Bertrand OF
    . Identifying which patients with diabetes should be tested for the presence of coronary artery disease–the importance of baseline electrocardiogram and exercise testing. Can J Cardiol 2006;22(suppl A):9A–15A
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Bobb JF,
    2. Schwartz BS,
    3. Davatzikos C, et al
    . Cross-sectional and longitudinal association of body mass index and brain volume. Hum Brain Mapp 2014;35:75–88
    CrossRefPubMed
  23. 23.↵
    1. Boyle CP,
    2. Raji CA,
    3. Erickson KI, et al
    . Physical activity, body mass index, and brain atrophy in Alzheimer's disease. Neurobiol Aging 2015;36(suppl 1):S194–202
    CrossRefPubMed
  24. 24.↵
    1. Driscoll I,
    2. Beydoun MA,
    3. An Y, et al
    . Midlife obesity and trajectories of brain volume changes in older adults. Hum Brain Mapp 2012;33:2204–10
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Marks BL,
    2. Madden DJ,
    3. Bucur B, et al
    . Role of aerobic fitness and aging on cerebral white matter integrity. Ann N Y Acad Sci 2007;1097:171–74
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Stanek KM,
    2. Grieve SM,
    3. Brickman AM, et al
    . Obesity is associated with reduced white matter integrity in otherwise healthy adults. Obesity 2011;19:500–04
    CrossRefPubMed
  27. 27.↵
    1. Bondi MW,
    2. Houston WS,
    3. Eyler LT, et al
    . fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease. Neurology 2005;64:501–08
    CrossRefPubMed
  28. 28.↵
    1. Braskie MN,
    2. Small GW,
    3. Bookheimer SY
    . Vascular health risks and fMRI activation during a memory task in older adults. Neurobiol Aging 2010;31:1532–42
    CrossRefPubMed
  29. 29.↵
    1. Gonzales MM,
    2. Tarumi T,
    3. Miles SC, et al
    . Insulin sensitivity as a mediator of the relationship between BMI and working memory-related brain activation. Obesity 2010;18:2131–37
    CrossRefPubMed
  30. 30.↵
    1. Volkow ND,
    2. Wang GJ,
    3. Telang F, et al
    . Inverse association between BMI and prefrontal metabolic activity in healthy adults. Obesity 2009;17:60–65
    CrossRefPubMed
  31. 31.↵
    1. Gonzales MM,
    2. Kaur S,
    3. Eagan DE, et al
    . Central adiposity and the functional magnetic resonance imaging response to cognitive challenge. Int J Obes (Lond) 2014;38:1193–99
    CrossRefPubMed
  32. 32.↵
    1. Nagamatsu LS,
    2. Handy TC,
    3. Hsu CL, et al
    . Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment. Arch Intern Med 2012;172:666–68
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Gates N,
    2. Fiatarone Singh MA,
    3. Sachdev PS, et al
    . The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials. Am J Geriatr Psychiatry 2013;21:1086–97
    CrossRefPubMed
  34. 34.↵
    1. Hamer M,
    2. Chida Y
    . Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med 2009;39:3–11
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Bherer L,
    2. Erickson KI,
    3. Liu-Ambrose T
    . A review of the effects of physical activity and exercise on cognitive and brain functions in older adults. J Aging Res 2013;2013:657508
    CrossRefPubMed
  36. 36.↵
    1. Barnes DE,
    2. Whitmer RA,
    3. Yaffe K
    . Physical activity and dementia: the need for prevention trials. Exerc Sport Sci Rev 2007;35:24–29
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. de Rezende LF,
    2. Rey-López JP,
    3. Matsudo VK, et al
    . Sedentary behavior and health outcomes among older adults: a systematic review. BMC Public Health 2014;14:333
    CrossRefPubMed
  38. 38.↵
    1. Profenno LA,
    2. Porsteinsson AP,
    3. Faraone SV
    . Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry 2010;67:505–12
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Kennelly SP,
    2. Lawlor BA,
    3. Kenny RA
    . Blood pressure and the risk for dementia: a double edged sword. Ageing Res Rev 2009;8:61–70
    CrossRefPubMedWeb of Science
  40. 40.↵
    1. Voss MW,
    2. Carr LJ,
    3. Clark R, et al
    . Revenge of the “sit” II: does lifestyle impact neuronal and cognitive health through distinct mechanisms associated with sedentary behavior and physical activity? Ment Health Physical Act 2014;7:9–24
    CrossRef
  41. 41.↵
    1. Colcombe SJ,
    2. Kramer AF,
    3. McAuley E, et al
    . Neurocognitive aging and cardiovascular fitness: recent findings and future directions. J Mol Neurosci 2004;24:9–14
    CrossRefPubMedWeb of Science
  42. 42.↵
    1. Colcombe SJ,
    2. Erickson KI,
    3. Scalf PE, et al
    . Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci 2006;61:1166–70
    Abstract/FREE Full Text
  43. 43.↵
    1. Erickson KI,
    2. Prakash RS,
    3. Voss MW, et al
    . Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 2009;19:1030–39
    CrossRefPubMedWeb of Science
  44. 44.↵
    1. Makizako H,
    2. Liu-Ambrose T,
    3. Shimada H, et al
    . Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment. J Gerontol A Biol Sci Med Sci 2015;70:480–86
    Abstract/FREE Full Text
  45. 45.↵
    1. Erickson KI,
    2. Voss MW,
    3. Prakash RS, et al
    . Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A 2011;108:3017–22
    Abstract/FREE Full Text
  46. 46.↵
    1. Kirk-Sanchez NJ,
    2. McGough EL
    . Physical exercise and cognitive performance in the elderly: current perspectives. Clin Interv Aging 2014;9:51–62
    PubMed
  47. 47.↵
    1. Fein G,
    2. Di Sclafani V,
    3. Tanabe J, et al
    . Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease. Neurology 2000;55:1626–35
    CrossRefPubMed
  48. 48.↵
    1. Mueller SG,
    2. Schuff N,
    3. Yaffe K, et al
    . Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease. Hum Brain Mapp 2010;31:1339–47
    CrossRefPubMedWeb of Science
  49. 49.↵
    1. Zlatar ZZ,
    2. Wierenga CE,
    3. Bangen KJ, et al
    . Increased hippocampal blood flow in sedentary older adults at genetic risk for Alzheimer's disease. J Alzheimers Dis 2014;41:809–17
    PubMed
  50. 50.↵
    1. Xu X,
    2. Jerskey BA,
    3. Cote DM, et al
    . Cerebrovascular perfusion among older adults is moderated by strength training and gender. Neurosci Lett 2014;560:26–30
    CrossRefPubMed
  51. 51.↵
    1. Liu-Ambrose T,
    2. Nagamatsu LS,
    3. Voss MW, et al
    . Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiol Aging 2012;33:1690–98
    CrossRefPubMedWeb of Science
  52. 52.↵
    1. Niemann C,
    2. Godde B,
    3. Voelcker-Rehage C
    . Not only cardiovascular, but also coordinative exercise increases hippocampal volume in older adults. Front Aging Neurosci 2014;6:170
    PubMed
  53. 53.↵
    1. Tseng BY,
    2. Gundapuneedi T,
    3. Khan MA, et al
    . White matter integrity in physically fit older adults. Neuroimage 2013;82:510–16
    CrossRefPubMedWeb of Science
  54. 54.↵
    1. Tian Q,
    2. Erickson KI,
    3. Simonsick EM, et al
    . Physical activity predicts microstructural integrity in memory-related networks in very old adults. J Gerontol A Biol Sci Med Sci 2014;69:1284–90
    Abstract/FREE Full Text
  55. 55.↵
    1. Voss MW,
    2. Heo S,
    3. Prakash RS, et al
    . The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Mapp 2013;34:2972–85
    CrossRefPubMedWeb of Science
  56. 56.↵
    1. Voss MW,
    2. Erickson KI,
    3. Prakash RS, et al
    . Neurobiological markers of exercise-related brain plasticity in older adults. Brain Behav Immun 2013;28:90–99
    CrossRefPubMed
  57. 57.↵
    1. Head D,
    2. Bugg JM,
    3. Goate AM, et al
    . Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition. Arch Neurol 2012;69:636–43
    CrossRefPubMedWeb of Science
  58. 58.↵
    1. Liang KY,
    2. Mintun MA,
    3. Fagan AM, et al
    . Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Ann Neurol 2010;68:311–18
    CrossRefPubMedWeb of Science
  59. 59.↵
    1. Brown BM,
    2. Peiffer JJ,
    3. Taddei K, et al
    . Physical activity and amyloid-â plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Mol Psychiatry 2013;18:875–81
    CrossRefPubMedWeb of Science
  60. 60.↵
    1. Vemuri P,
    2. Lesnick TG,
    3. Przybelski SA, et al
    . Effect of lifestyle activities on Alzheimer disease biomarkers and cognition. Ann Neurol 2012;72:730–38
    CrossRefPubMed
  61. 61.↵
    1. Bugg JM,
    2. Head D
    . Exercise moderates age-related atrophy of the medial temporal lobe. Neurobiol Aging 2011;32:506–14
    CrossRefPubMedWeb of Science
  62. 62.↵
    1. Okonkwo OC,
    2. Schultz SA,
    3. Oh JM, et al
    . Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology 2014;83:1753–60
    CrossRefPubMed
  63. 63.↵
    1. Rathakrishnan BG,
    2. Doraiswamy PM,
    3. Petrella JR
    . Science to practice: translating automated brain MRI volumetry in Alzheimer's disease from research to routine diagnostic use in the work-up of dementia. Front Neurol 2014;4:216
    PubMed
  64. 64.↵
    1. Stein DJ,
    2. He Y,
    3. Phillips A, et al
    . Global mental health and neuroscience: potential synergies. Lancet Psychiatry 2015;2:178–85
    CrossRefPubMed
  65. 65.↵
    1. Gregory MA,
    2. Gill DP,
    3. Petrella RJ
    . Brain health and exercise in older adults. Curr Sports Med Rep 2013;12:256–71
    CrossRefPubMed
  66. 66.↵
    1. Cederholm T,
    2. Salem N Jr.,
    3. Palmblad J
    . ω-3 fatty acids in the prevention of cognitive decline in humans. Adv Nutr 2013;4:672–76
    Abstract/FREE Full Text
  67. 67.↵
    1. Brickman AM,
    2. Khan UA,
    3. Provenzano FA, et al
    . Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nat Neurosci 2014;17:1798–803
    CrossRefPubMed
  68. 68.↵
    1. Mosconi L,
    2. Murray J,
    3. Tsui WH, et al
    . Mediterranean diet and magnetic resonance imaging-assessed brain atrophy in cognitively normal individuals at risk for Alzheimer's disease. J Prev of Alzheimers Dis 2014;1:23–32
  69. 69.↵
    1. Videbech P,
    2. Ravnkilde B
    . Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 2004;161:1957–66
    CrossRefPubMedWeb of Science
  70. 70.↵
    1. Dazzan P,
    2. Soulsby B,
    3. Mechelli A, et al
    . Volumetric abnormalities predating the onset of schizophrenia and affective psychoses: an MRI study in subjects at ultrahigh risk of psychosis. Schizophr Bull 2012;38:1083–91
    Abstract/FREE Full Text
  71. 71.↵
    1. MacIntosh BJ,
    2. Swardfager W,
    3. Crane DE, et al
    . Cardiopulmonary fitness correlates with regional cerebral grey matter perfusion and density in men with coronary artery disease. PLoS One 2014;9:e91251
    CrossRefPubMed
  72. 72.↵
    1. Norbash A,
    2. Bluth E,
    3. Lee CI, et al
    . Radiologist manpower considerations and Imaging 3.0: effort planning for value-based imaging. J Am Coll Radiol 2014;11:953–58
    CrossRefPubMed
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American Journal of Neuroradiology: 36 (10)
American Journal of Neuroradiology
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Cite this article
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga, M.W. Vernooij
Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
American Journal of Neuroradiology Oct 2015, 36 (10) 1803-1809; DOI: 10.3174/ajnr.A4409

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Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga, M.W. Vernooij
American Journal of Neuroradiology Oct 2015, 36 (10) 1803-1809; DOI: 10.3174/ajnr.A4409
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    • ABBREVIATIONS:
    • Obesity and Age-Related Cognitive Decline
    • Physical Activity and Age-Related Cognitive Decline
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