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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine Imaging and Spine Image-Guided Interventions

Acute Myelopathy or Cauda Equina Syndrome in HIV-Positive Adults in a Tuberculosis Endemic Setting: MRI, Clinical, and Pathologic Findings

S. Candy, G. Chang and S. Andronikou
American Journal of Neuroradiology August 2014, 35 (8) 1634-1641; DOI: https://doi.org/10.3174/ajnr.A3958
S. Candy
aFrom the Department of Radiology (S.C., G.C.), Groote Schuur Hospital, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
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G. Chang
aFrom the Department of Radiology (S.C., G.C.), Groote Schuur Hospital, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
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S. Andronikou
bDepartment of Radiology (S.A.), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
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  • Fig 1.
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    Fig 1.

    Summary of causation of myelopathy. Abbreviations: CC indicates cryptococcus; Zoster, Varicella zoster; MA, Mycobacterium avium; EC, enterococcus; and MEAS, measles; CMV, cytomegalovirus.

  • Fig 2.
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    Fig 2.

    Tuberculous spondylo-diskitis. A, Sagittal T2-weighted MR imaging demonstrates caseous destruction of the L2–3 disk with epidural collection causing compression of the conus. B, Coronal FISP demonstrates large psoas abscesses communicating with the L2–3 disk. A thick walled collection displaces the right kidney superiorly.

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    Fig 3.

    Nonspondylitic spinal tuberculosis. A, T1 sagittal pregadolinium image with increased signal of the CSF. B, T2 sagittal shows root thickening. C and D, T1 sagittal postgadolinium demonstrates circumferential cord and root enhancement. E, T2 sagittal shows loculated CSF with extensive cord signal abnormality.

  • Fig 4.
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    Fig 4.

    Burkitt lymphoma. A, Coronal FISP showing nonfluid-containing right L2/3 paraspinal and right pelvic masses infiltrating the right iliac bone and multiple low-signal lesions in both renal cortices. B, Sagittal T1 shows diffusely low marrow signal with isointense epidural masses posterior to the bodies of L5, S1, and S2.

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    Fig 5.

    Plasmablastic lymphoma. A, Axial T2-weighted MR imaging shows a large destructive lobulated mass in the left hemithorax infiltrating the thoracic spinal canal via the neural foramen. B, T2-weighted sagittal MR imaging showing posterior epidural cord compression.

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    Fig 6.

    EB-associated myopericytoma. A, Sagittal T2-weighted MR imaging shows predominantly low-signal epidural mass causing significant cord compression at T6/7 with abnormal marrow in the adjacent vertebral body. B, Coronal FISP demonstrates improved conspicuity of marrow signal abnormality. C, Axial T2-weighted image shows tumor displacing and compressing the cord.

Tables

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    Table 1:

    MRI-based pathologic categories in 216 patients with HIV and acute onset myelopathy/cauda equina

    MRI NormalMRI Abnormal
    Normal GroupSpondylitis GroupNonspondylitis Groups
    SpondylitisArachnoiditis-Myelitis Intramedullary TuberculomasNeoplasm NonboneNeoplasm BoneOther
    HIV AssociatedLymphomaLymphomaPlasmacytomaMetsDiskSyrinx?
    55656421034823
    • Note:—? indicates no final diagnosis.

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    Table 2:

    Mycobacterium tuberculosis as a cause of myelopathy/cauda equina syndrome in subset of patients with a confirmed aetiology on laboratory testing

    MRI SpondylitisMRI NonspondylitisTotal
    TB
        Yes572683
        No04040
    Total5766123
    • View popup
    Table 3:

    Comparison of myelitis group and normal MRI groups with regard to CSF parameters using Mann-Whitney U test

    MRI GroupLymphocyte Count Median (per mm3) and RangePolymorphonuclear Median (per mm3) and RangeProtein Median (g/l) Normal 0.15–0.45 and Range
    Myelitis38.5 (0–265)0 (0–300)2 (0.14–2)
    Normal1 (0–160)0 (0–5)0.49 (0.11–2.6)
    P value.0053a.2082.0017a
    • ↵a Indicates significance.

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American Journal of Neuroradiology: 35 (8)
American Journal of Neuroradiology
Vol. 35, Issue 8
1 Aug 2014
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Cite this article
S. Candy, G. Chang, S. Andronikou
Acute Myelopathy or Cauda Equina Syndrome in HIV-Positive Adults in a Tuberculosis Endemic Setting: MRI, Clinical, and Pathologic Findings
American Journal of Neuroradiology Aug 2014, 35 (8) 1634-1641; DOI: 10.3174/ajnr.A3958

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Acute Myelopathy or Cauda Equina Syndrome in HIV-Positive Adults in a Tuberculosis Endemic Setting: MRI, Clinical, and Pathologic Findings
S. Candy, G. Chang, S. Andronikou
American Journal of Neuroradiology Aug 2014, 35 (8) 1634-1641; DOI: 10.3174/ajnr.A3958
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