Article Figures & Data
Figures
- Fig 1.
DTI indices maps (P < .05, corrected) are represented in the FMRIB58_FA template on the axial plan with z-axis coordinates (in millimeters) above the upper row images. Green corresponds to the mean white matter skeleton of all participants. A, Red-yellow represents decreased FA. B, Pink-light pink represents increased MD. C, Blue-light blue represents increased RD.
- Fig 2.
Conjunction map of spatial differences between reduced FA and increased RD maps, represented in the FMRIB58_FA template on the axial plane with Montreal Neurological Institute 152 coordinates (in millimeters) above each upper row image. Red-yellow represents decreased FA; blue-light blue, increased RD. A decrease in FA alone shows an anterior frontal circuitry pattern, while an increase in RD is more prominent in the posterior supratentorial brain regions and brain stem.
Tables
- Table 1:
Demographic and clinical characteristics for patients with HSP and the control groupa
Patients with HSP (n = 12) Healthy Controls (n = 12) P Value Age at MRI (yr) 50 (49 ± 8) 48 (48 ± 5) .5b Sex (female) 50% 67% .4c Disease duration (yr) 23 (24 ± 16) – – Disease onset (yr) 23 (25 ± 18) – – Spastic gate loci SPG10 8% (1) SPG3a 8% (1) SPG4 58% (7) SPG7+SPG4 8% (1) SPG5 17% (2) - Table 2:
Suprathreshold (P < .05, corrected) cluster distribution (%) respectively for FA, MD, and RD indices
JHU White-Matter Tractography Atlas Labels FA MD RD L anterior thalamic radiation 1.27 1.17 1.54 R anterior thalamic radiation 0.81 0.94 1.01 L corticospinal tract 0.96 0.95 0.96 R corticospinal tract 1.03 1.40 1.02 L cingulum (cingulate gyrus) 0.44 0.28 0.43 Corpus callosum with forceps major 1.26 1.94 1.17 Corpus callosum with forceps minor 3.26 2.63 2.04 L inferior fronto-occipital fasciculus 1.95 0.40 1.80 R inferior fronto-occipital fasciculus 1.47 1.85 1.79 L inferior longitudinal fasciculus 0.93 0.30 1.58 R inferior longitudinal fasciculus 2.02 0.88 1.22 L superior longitudinal fasciculus 1.10 3.13 1.98 R superior longitudinal fasciculus 0.76 3.56 1.67 L superior longitudinal fasciculus (temporal part) 0.96 1.01 0.96 R superior longitudinal fasciculus (temporal part) 0.44 1.07 0.66 Note:—L indicates left; R, right.
