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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Regional Cerebral Blood Flow in Children From 3 to 5 Months of Age

A.F. Duncan, A. Caprihan, E.Q. Montague, J. Lowe, R. Schrader and J.P. Phillips
American Journal of Neuroradiology March 2014, 35 (3) 593-598; DOI: https://doi.org/10.3174/ajnr.A3728
A.F. Duncan
aFrom the Department of Pediatrics, Division of Neonatology (A.F.D., J.L.)
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A. Caprihan
dThe MIND Research Network (A.C.), Albuquerque, New Mexico
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E.Q. Montague
eNeuroDevelopmental Science Center (E.Q.M.), Akron Children's Hospital, Akron, Ohio.
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J. Lowe
aFrom the Department of Pediatrics, Division of Neonatology (A.F.D., J.L.)
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R. Schrader
bClinical and Translational Science Center (R.S.)
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J.P. Phillips
cDepartment of Neurology (J.P.P.), University of New Mexico, Albuquerque, New Mexico
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    Fig 1.

    A and B, Brain segmentation process of the 9-month template is shown; C, 4-month T1 image; D, corresponding atlas after mathematica transformation. E, CBF image; F, CBF image with the atlas overlaid to demonstrate how well they are registered; G, the 8 segments projected onto the cortical surface.

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    Fig 2.

    Regional differences in CBF. Although there were no significant differences within the 3 higher flow regions (sensorimotor, parieto-occipital, and inferior-occipital; P = .43) or within the 3 lower flow regions (subgenual, orbito-frontal, and dorsolateral prefrontal; P = .15), mean CBF between the high and low groups was highly significant. The mixed model fit age in a continuous manner, but, for illustrative purposes, age is split at the median. Horizontal dotted line is the median CBF value across all regions and ages.

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    Fig 3.

    Regions with CBF above study population median are shown in shades of red and those regions with CBF below the median are shown in shades of blue. Darker color indicates greater deviation from the median flow. Thus, the sensorimotor (SM) region had the highest flow above the median and the dorsolateral prefrontal (DLPF) region had the lowest flow below the median.

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    Fig 4.

    Cerebral blood flow versus age within each region; ρ is Spearman rank correlation coefficient.

Tables

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  • Demographic information for study subjects

    Total (n = 61)Male (n = 37) (61%)Female (n = 24) (39%)
    Birth weight, g3,294.95 ± 432.23,363.6 ± 408.83,190.5 ± 554.6
    Gestational age, wk39.2 ± 1.437.3 ± 9.138.9 ± 1.5
    Age at scanning, d123.6 ± 13122.3 ± 12.6125.5 ± 13.4a
    Sex, % girlsa39%
    Ethnicitya
    White15 (24.59%)8 (21.62%)7 (29.16%)
    Black1 (1.64%)1 (2.70%)0 (0%)
    Hispanic34 (55.73%)21 (56.75%)13 (54.16%)
    Native American3 (4.92%)2 (5.40%)1 (4.16%)
    Other4 (6.55%)3 (8.10%)1 (4.16%)
    Unknown4 (6.55%)2 (5.40%)2 (8.33%)
    • Note:—Values are depicted as means ± standard deviations unless otherwise indicated.

    • ↵a P < .05.

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American Journal of Neuroradiology: 35 (3)
American Journal of Neuroradiology
Vol. 35, Issue 3
1 Mar 2014
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Cite this article
A.F. Duncan, A. Caprihan, E.Q. Montague, J. Lowe, R. Schrader, J.P. Phillips
Regional Cerebral Blood Flow in Children From 3 to 5 Months of Age
American Journal of Neuroradiology Mar 2014, 35 (3) 593-598; DOI: 10.3174/ajnr.A3728

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Regional Cerebral Blood Flow in Children From 3 to 5 Months of Age
A.F. Duncan, A. Caprihan, E.Q. Montague, J. Lowe, R. Schrader, J.P. Phillips
American Journal of Neuroradiology Mar 2014, 35 (3) 593-598; DOI: 10.3174/ajnr.A3728
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