Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Susceptibility-Diffusion Mismatch Predicts Thrombolytic Outcomes: A Retrospective Cohort Study

M. Lou, Z. Chen, J. Wan, H. Hu, X. Cai, Z. Shi and J. Sun
American Journal of Neuroradiology November 2014, 35 (11) 2061-2067; DOI: https://doi.org/10.3174/ajnr.A4017
M. Lou
aFrom the Departments of Neurology (M.L., Z.C., J.W., H.H., X.C., Z.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Z. Chen
aFrom the Departments of Neurology (M.L., Z.C., J.W., H.H., X.C., Z.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Wan
aFrom the Departments of Neurology (M.L., Z.C., J.W., H.H., X.C., Z.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H. Hu
aFrom the Departments of Neurology (M.L., Z.C., J.W., H.H., X.C., Z.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
X. Cai
aFrom the Departments of Neurology (M.L., Z.C., J.W., H.H., X.C., Z.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Z. Shi
aFrom the Departments of Neurology (M.L., Z.C., J.W., H.H., X.C., Z.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Sun
bRadiology (J.S.), the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Hacke W,
    2. Kaste M,
    3. Bluhmki E, et al
    . Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317–29
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Bivard A,
    2. Spratt N,
    3. Levi CR, et al
    . Acute stroke thrombolysis: time to dispense with the clock and move to tissue-based decision making? Expert Rev Cardiovasc Ther 2011;9:451–61
    CrossRefPubMed
  3. 3.↵
    1. Grandin CB,
    2. Duprez TP,
    3. Smith AM, et al
    . Which MR-derived perfusion parameters are the best predictors of infarct growth in hyperacute stroke? Comparative study between relative and quantitative measurements. Radiology 2002;223:361–70
    CrossRefPubMed
  4. 4.↵
    1. Heiss WD
    . The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke: the Johann Jacob Wepfer award 2011. Cerebrovasc Dis 2011;32:307–20
    CrossRefPubMed
  5. 5.↵
    1. Sobesky J
    . Refining the mismatch concept in acute stroke: lessons learned from PET and MRI. J Cereb Blood Flow Metab 2012;32:1416–25
    CrossRefPubMed
  6. 6.↵
    1. Wang M,
    2. Dai Y,
    3. Han Y, et al
    . Susceptibility weighted imaging in detecting hemorrhage in acute cervical spinal cord injury. Magn Reson Imaging 2011;29:365–73
    CrossRefPubMed
  7. 7.↵
    1. Haacke EM,
    2. Xu Y,
    3. Cheng YC, et al
    . Susceptibility weighted imaging (SWI). Magn Reson Med 2004;52:612–18
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. An H,
    2. Lin W
    . Quantitative measurements of cerebral blood oxygen saturation using magnetic resonance imaging. J Cereb Blood Flow Metab 2000;20:1225–36
    PubMedWeb of Science
  9. 9.↵
    1. Hermier M,
    2. Nighoghossian N,
    3. Derex L, et al
    . Hypointense transcerebral veins at T2*-weighted MRI: a marker of hemorrhagic transformation risk in patients treated with intravenous tissue plasminogen activator. J Cereb Blood Flow Metab 2003;23:1362–70
    CrossRefPubMed
  10. 10.↵
    1. Lee JM,
    2. Vo KD,
    3. An H, et al
    . Magnetic resonance cerebral metabolic rate of oxygen utilization in hyperacute stroke patients. Ann Neurol 2003;53:227–32
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Heiss WD
    . Ischemic penumbra: evidence from functional imaging in man. J Cereb Blood Flow Metab 2000;20:1276–93
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Powers WJ
    . Cerebral hemodynamics in ischemic cerebrovascular disease. Ann Neurol 1991;29:231–40
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Robertson CA,
    2. McCabe C,
    3. Gallagher L, et al
    . Stroke penumbra defined by an MRI-based oxygen challenge technique. 2. Validation based on the consequences of reperfusion. J Cereb Blood Flow Metab 2011;31:1788–98
    CrossRefPubMed
  14. 14.↵
    1. Santosh C,
    2. Brennan D,
    3. McCabe C, et al
    . Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. J Cereb Blood Flow Metab 2008;28:1742–53
    CrossRefPubMed
  15. 15.↵
    1. Hermier M,
    2. Nighoghossian N,
    3. Derex L, et al
    . Hypointense leptomeningeal vessels at T2*-weighted MRI in acute ischemic stroke. Neurology 2005;65:652–53
    CrossRef
  16. 16.↵
    1. Davis SM,
    2. Donnan GA,
    3. Parsons MW, et al
    . Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 2008;7:299–309
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Jauch EC,
    2. Saver JL,
    3. Adams HP Jr., et al
    . Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013;44:870–947
    Abstract/FREE Full Text
  18. 18.↵
    1. Cappellari M,
    2. Bovi P,
    3. Moretto G, et al
    . The THRombolysis and STatins (THRaST) study. Neurology 2013;80:655–61
    CrossRef
  19. 19.↵
    1. Olivot JM,
    2. Mlynash M,
    3. Thijs VN, et al
    . Relationships between cerebral perfusion and reversibility of acute diffusion lesions in DEFUSE: insights from RADAR. Stroke 2009;40:1692–97
    Abstract/FREE Full Text
  20. 20.↵
    1. Kakuda W,
    2. Lansberg MG,
    3. Thijs VN, et al
    . Optimal definition for PWI/DWI mismatch in acute ischemic stroke patients. J Cereb Blood Flow Metab 2008;28:887–91
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Olivot JM,
    2. Mlynash M,
    3. Thijs VN, et al
    . Optimal Tmax threshold for predicting penumbral tissue in acute stroke. Stroke 2009;40:469–75
    Abstract/FREE Full Text
  22. 22.↵
    1. Lansberg MG,
    2. Straka M,
    3. Kemp S, et al
    . MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol 2012;11:860–67
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Straka M,
    2. Albers GW,
    3. Bammer R
    . Real-time diffusion-perfusion mismatch analysis in acute stroke. J Magn Reson Imaging 2010;32:1024–37
    CrossRefPubMed
  24. 24.↵
    1. Fiebach JB,
    2. Al-Rawi Y,
    3. Wintermark M, et al
    . Vascular occlusion enables selecting acute ischemic stroke patients for treatment with desmoteplase. Stroke 2012;43:1561–66
    Abstract/FREE Full Text
  25. 25.↵
    1. Jensen-Kondering U,
    2. Böhm R
    . Asymmetrically hypointense veins on T2*w imaging and susceptibility-weighted imaging in ischemic stroke. World J Radiol 2013;5:156–65
    PubMed
  26. 26.↵
    1. Rosso C,
    2. Belleville M,
    3. Pires C, et al
    . Clinical usefulness of the visibility of the transcerebral veins at 3T on T2*-weighted sequence in acute stroke patients. Eur J Radiol 2012;81:1282–87
    CrossRefPubMed
  27. 27.↵
    1. Kao HW,
    2. Tsai FY,
    3. Hasso AN
    . Predicting stroke evolution: comparison of susceptibility-weighted MR imaging with MR perfusion. Eur Radiol 2012;22:1397–403
    CrossRefPubMed
  28. 28.↵
    1. Lansberg MG,
    2. Thijs VN,
    3. Bammer R, et al
    . The MRA-DWI mismatch identifies patients with stroke who are likely to benefit from reperfusion. Stroke 2008;39:2491–96
    Abstract/FREE Full Text
  29. 29.↵
    1. Parsons MW,
    2. Christensen S,
    3. McElduff P, et al
    . Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis. J Cereb Blood Flow Metab 2010;30:1214–25
    CrossRefPubMed
  30. 30.↵
    1. Albers GW,
    2. Thijs VN,
    3. Wechsler L, et al
    . Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 2006;60:508–17
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Sheerin F
    . The imaging of the cerebral venous sinuses. Semin Ultrasound CT MR 2009;30:525–58
    CrossRefPubMed
  32. 32.↵
    1. Leach JL,
    2. Fortuna RB,
    3. Jones BV, et al
    . Imaging of cerebral venous thrombosis: current techniques, spectrum of findings, and diagnostic pitfalls. Radiographics 2006;26(suppl 1):S19–41, discussion S42–43
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Oran I,
    2. Memis A,
    3. Sener RN, et al
    . The so-called transcerebral veins: appearance in three different cases. Comput Med Imaging Graph 1999;23:127–31
    CrossRefPubMed
  34. 34.↵
    1. Hakim AM,
    2. Evans AC,
    3. Berger L, et al
    . The effect of nimodipine on the evolution of human cerebral infarction studied by PET. J Cereb Blood Flow Metab 1989;9:523–34
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Wise RJ,
    2. Bernardi S,
    3. Frackowiak RS, et al
    . Serial observations on the pathophysiology of acute stroke: the transition from ischaemia to infarction as reflected in regional oxygen extraction. Brain 1983;106(pt 1):197–222
    Abstract/FREE Full Text
  36. 36.↵
    1. Kidwell CS,
    2. Alger JR,
    3. Saver JL
    . Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke 2003;34:2729–35
    Abstract/FREE Full Text
  37. 37.↵
    1. Marckmann P,
    2. Skov L,
    3. Rossen K, et al
    . Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging. J Am Soc Nephrol 2006;17:2359–62
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 35 (11)
American Journal of Neuroradiology
Vol. 35, Issue 11
1 Nov 2014
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Susceptibility-Diffusion Mismatch Predicts Thrombolytic Outcomes: A Retrospective Cohort Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
M. Lou, Z. Chen, J. Wan, H. Hu, X. Cai, Z. Shi, J. Sun
Susceptibility-Diffusion Mismatch Predicts Thrombolytic Outcomes: A Retrospective Cohort Study
American Journal of Neuroradiology Nov 2014, 35 (11) 2061-2067; DOI: 10.3174/ajnr.A4017

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Susceptibility-Diffusion Mismatch Predicts Thrombolytic Outcomes: A Retrospective Cohort Study
M. Lou, Z. Chen, J. Wan, H. Hu, X. Cai, Z. Shi, J. Sun
American Journal of Neuroradiology Nov 2014, 35 (11) 2061-2067; DOI: 10.3174/ajnr.A4017
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Unfavorable neurological outcome in diabetic patients with acute ischemic stroke is associated with incomplete recanalization after intravenous thrombolysis
  • Prominence of Medullary Veins on Susceptibility-Weighted Images Provides Prognostic Information in Patients with Subacute Stroke
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
  • Quiet PROPELLER MRI Techniques Match the Quality of Conventional PROPELLER Brain Imaging Techniques
  • Predictors of Reperfusion in Patients with Acute Ischemic Stroke
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire