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CFD: Computational Fluid Dynamics or Confounding Factor Dissemination? The Role of Hemodynamics in Intracranial Aneurysm Rupture Risk Assessment

J. Xiang, V.M. Tutino, K.V. Snyder and H. Meng
American Journal of Neuroradiology October 2014, 35 (10) 1849-1857; DOI: https://doi.org/10.3174/ajnr.A3710
J. Xiang
aFrom the Toshiba Stroke and Vascular Research Center (J.X., V.M.T., K.V.S., H.M.)
bDepartments of Neurosurgery (J.X.)
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V.M. Tutino
aFrom the Toshiba Stroke and Vascular Research Center (J.X., V.M.T., K.V.S., H.M.)
cBiomedical Engineering (V.M.T.)
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K.V. Snyder
aFrom the Toshiba Stroke and Vascular Research Center (J.X., V.M.T., K.V.S., H.M.)
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H. Meng
aFrom the Toshiba Stroke and Vascular Research Center (J.X., V.M.T., K.V.S., H.M.)
dMechanical and Aerospace Engineering (H.M.), University at Buffalo, State University of New York, Buffalo, New York.
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    Fig 1.

    Longitudinally followed aneurysms show correlation between growth and low WSS. A, Overlying 3D images of a basilar-trunk aneurysm from consecutive years show dramatic size increase in the direction of the lowest WSS.2 B, Linear correlation between local displacement of IA wall (IA enlargement) and inverse of time-averaged WSS (P < .001) in a follow-up study analyzing 7 growing IAs by the same group.17 Reproduced with permission from Acevedo-Bolton G, Jou LD, Dispensa BP, et al. Estimating the hemodynamic impact of interventional treatments of aneurysms: numerical simulation with experimental validation: technical case report. Neurosurgery 2006;59:E429–30 and Boussel L, Rayz V, McCulloch C, et al. Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study. Stroke 2008;39:2997–3002.

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    Fig 2.

    Examples of WSS distributions in ruptured (top 2 rows) and unruptured aneurysms (bottom 2 rows) from a study of 119 aneurysms by Xiang et al.4 Ruptured aneurysms were associated with lower aneurysmal WSS (P < .0001). Reproduction with permission from Xiang J, Natarajan SK, Tremmel M, et al. Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke 2011;42:144–52

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American Journal of Neuroradiology: 35 (10)
American Journal of Neuroradiology
Vol. 35, Issue 10
1 Oct 2014
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J. Xiang, V.M. Tutino, K.V. Snyder, H. Meng
CFD: Computational Fluid Dynamics or Confounding Factor Dissemination? The Role of Hemodynamics in Intracranial Aneurysm Rupture Risk Assessment
American Journal of Neuroradiology Oct 2014, 35 (10) 1849-1857; DOI: 10.3174/ajnr.A3710

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CFD: Computational Fluid Dynamics or Confounding Factor Dissemination? The Role of Hemodynamics in Intracranial Aneurysm Rupture Risk Assessment
J. Xiang, V.M. Tutino, K.V. Snyder, H. Meng
American Journal of Neuroradiology Oct 2014, 35 (10) 1849-1857; DOI: 10.3174/ajnr.A3710
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