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Research ArticleBrain

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

M. Filippi, E. Canu, R. Gasparotti, F. Agosta, P. Valsecchi, G. Lodoli, A. Galluzzo, G. Comi and E. Sacchetti
American Journal of Neuroradiology January 2014, 35 (1) 30-37; DOI: https://doi.org/10.3174/ajnr.A3583
M. Filippi
aFrom the Neuroimaging Research Unit (M.F., E.C., F.A.) Institute of Experimental Neurology, Division of Neuroscience
bDepartment of Neurology (M.F., G.C.) San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
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E. Canu
aFrom the Neuroimaging Research Unit (M.F., E.C., F.A.) Institute of Experimental Neurology, Division of Neuroscience
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R. Gasparotti
cDepartment of Diagnostic Imaging (R.G., G.L.), Neuroradiology Unit, Brescia University School of Medicine, Spedali Civili, Brescia, Italy
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F. Agosta
aFrom the Neuroimaging Research Unit (M.F., E.C., F.A.) Institute of Experimental Neurology, Division of Neuroscience
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P. Valsecchi
dDepartment of Mental Health (P.V., A.G., E.S.), Spedali Civili, Brescia, Italy
eUniversity Psychiatric Unit (P.V., E.S.), Brescia University School of Medicine, Brescia, Italy
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G. Lodoli
cDepartment of Diagnostic Imaging (R.G., G.L.), Neuroradiology Unit, Brescia University School of Medicine, Spedali Civili, Brescia, Italy
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A. Galluzzo
dDepartment of Mental Health (P.V., A.G., E.S.), Spedali Civili, Brescia, Italy
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G. Comi
bDepartment of Neurology (M.F., G.C.) San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
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E. Sacchetti
dDepartment of Mental Health (P.V., A.G., E.S.), Spedali Civili, Brescia, Italy
eUniversity Psychiatric Unit (P.V., E.S.), Brescia University School of Medicine, Brescia, Italy
fCentre on Behavioural and Neurodegenerative Disorders (E.S.), Brescia University and EULO, Brescia, Italy.
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REFERENCES

  1. 1.↵
    1. Peters BD,
    2. Blaas J,
    3. de Haan L
    . Diffusion tensor imaging in the early phase of schizophrenia: what have we learned? J Psychiatr Res 2010;44:993–1004
    CrossRefPubMed
  2. 2.↵
    1. Levitt JJ,
    2. Bobrow L,
    3. Lucia D,
    4. et al
    . A selective review of volumetric and morphometric imaging in schizophrenia. Curr Top Behav Neurosci 2010;4:243–81
    CrossRefPubMed
  3. 3.↵
    1. Ellison-Wright I,
    2. Bullmore E
    . Meta-analysis of diffusion tensor imaging studies in schizophrenia. Schizophr Res 2009;108:3–10
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Cheung V,
    2. Cheung C,
    3. McAlonan GM,
    4. et al
    . A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. Psychol Med 2008;38:877–85
    PubMedWeb of Science
  5. 5.↵
    1. Cheung V,
    2. Chiu CP,
    3. Law CW,
    4. et al
    . Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia. Psychol Med 2011;41:1709–19
    CrossRefPubMed
  6. 6.↵
    1. Gasparotti R,
    2. Valsecchi P,
    3. Carletti F,
    4. et al
    . Reduced fractional anisotropy of corpus callosum in first-contact, antipsychotic drug-naive patients with schizophrenia. Schizophr Res 2009;108:41–48
    CrossRefPubMed
  7. 7.↵
    1. Guo W,
    2. Liu F,
    3. Liu Z,
    4. et al
    . Right lateralized white matter abnormalities in first-episode, drug-naive paranoid schizophrenia. Neurosci Lett 2012;531:5–9
    CrossRefPubMed
  8. 8.↵
    1. Pérez-Iglesias R,
    2. Tordesillas-Gutiérrez D,
    3. Barker GJ,
    4. et al
    . White matter defects in first episode psychosis patients: a voxelwise analysis of diffusion tensor imaging. Neuroimage 2010;49:199–204
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Zou LQ,
    2. Xie JX,
    3. Yuan HS,
    4. et al
    . Diffusion tensor imaging study of the anterior limb of internal capsules in neuroleptic-naive schizophrenia. Acad Radiol 2008;15:285–89
    CrossRefPubMed
  10. 10.↵
    1. Szeszko PR,
    2. Robinson DG,
    3. Ashtari M,
    4. et al
    . Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia. Neuropsychopharmacology 2008;33:976–84
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Folstein MF,
    2. Folstein SE,
    3. McHugh PR
    . “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–98
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Wechsler D
    . WAIS-R Manual. Wechsler Adult Intelligence Scale Revised. New York: The Psychological Corporation; 1981
  13. 13.↵
    Association AP. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) 4th ed. Washington, DC: American Psychiatric Association; 1994
  14. 14.↵
    1. Sacchetti E,
    2. Bocchio-Chiavetto L,
    3. Valsecchi P,
    4. et al
    . −G308A tumor necrosis factor alpha functional polymorphism and schizophrenia risk: meta-analysis plus association study. Brain Behav Immun 2007;21:450–57
    CrossRefPubMed
  15. 15.↵
    1. Craig TJ,
    2. Bromet EJ,
    3. Fennig S,
    4. et al
    . Is there an association between duration of untreated psychosis and 24-month clinical outcome in a first-admission series? Am J Psychiatry 2000;157:60–66
    PubMedWeb of Science
  16. 16.↵
    1. Kay SR,
    2. Fiszbein A,
    3. Opler LA
    . The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261–76
    Abstract/FREE Full Text
  17. 17.↵
    1. Nichols TE,
    2. Holmes AP
    . Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp 2002;15:1–25
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Innocenti GM,
    2. Ansermet F,
    3. Parnas J
    . Schizophrenia, neurodevelopment and corpus callosum. Mol Psychiatry 2003;8:261–74
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Kyriakopoulos M,
    2. Frangou S
    . Recent diffusion tensor imaging findings in early stages of schizophrenia. Curr Opin Psychiatry 2009;22:168–76
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Uranova N,
    2. Orlovskaya D,
    3. Vikhreva O,
    4. et al
    . Electron microscopy of oligodendroglia in severe mental illness. Brain Res Bull 2001;55:597–610
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Koch K,
    2. Wagner G,
    3. Dahnke R,
    4. et al
    . Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia. Eur Arch Psychiatry Clin Neurosci 2010;260:419–26
    CrossRefPubMed
  22. 22.↵
    1. Sun Z,
    2. Wang F,
    3. Cui L,
    4. et al
    . Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study. Neuroreport 2003;14:1833–36
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Federspiel A,
    2. Begre S,
    3. Kiefer C,
    4. et al
    . Alterations of white matter connectivity in first episode schizophrenia. Neurobiol Dis 2006;22:702–09
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Chance SA,
    2. Highley JR,
    3. Esiri MM,
    4. et al
    . Fiber content of the fornix in schizophrenia: lack of evidence for a primary limbic encephalopathy. Am J Psychiatry 1999;156:1720–24
    PubMedWeb of Science
  25. 25.↵
    1. Guillin O,
    2. Abi-Dargham A,
    3. Laruelle M
    . Neurobiology of dopamine in schizophrenia. Int Rev Neurobiol 2007;78:1–39
    PubMedWeb of Science
  26. 26.↵
    1. Hubl D,
    2. Koenig T,
    3. Strik W,
    4. et al
    . Pathways that make voices: white matter changes in auditory hallucinations. Arch Gen Psychiatry 2004;61:658–68
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Shergill SS,
    2. Brammer MJ,
    3. Fukuda R,
    4. et al
    . Engagement of brain areas implicated in processing inner speech in people with auditory hallucinations. Br J Psychiatry 2003;182:525–31
    Abstract/FREE Full Text
  28. 28.↵
    1. Seok JH,
    2. Park HJ,
    3. Chun JW,
    4. et al
    . White matter abnormalities associated with auditory hallucinations in schizophrenia: a combined study of voxel-based analyses of diffusion tensor imaging and structural magnetic resonance imaging. Psychiatry Res 2007;156:93–104
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Basser PJ,
    2. Mattiello J,
    3. LeBihan D
    . MR diffusion tensor spectroscopy and imaging. Biophys J 1994;66:259–67
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Beaulieu C
    . The basis of anisotropic water diffusion in the nervous system— a technical review. NMR Biomed 2002;15:435–55
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Song SK,
    2. Sun SW,
    3. Ramsbottom MJ,
    4. et al
    . Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002;17:1429–36
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Wheeler-Kingshott CA,
    2. Cercignani M
    . About “axial” and “radial” diffusivities. Magn Reson Med 2009;61:1255–60
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Bora E,
    2. Fornito A,
    3. Radua J,
    4. et al
    . Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysis. Schizophr Res 2011;127:46–57
    CrossRefPubMed
  34. 34.↵
    1. Di Rosa E,
    2. Crow TJ,
    3. Walker MA,
    4. et al
    . Reduced neuron density, enlarged minicolumn spacing and altered ageing effects in fusiform cortex in schizophrenia. Psychiatry Res 2009;166:102–15
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Vuilleumier P,
    2. Armony JL,
    3. Driver J,
    4. et al
    . Effects of attention and emotion on face processing in the human brain: an event-related fMRI study. Neuron 2001;30:829–41
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Thomann PA,
    2. Roebel M,
    3. Dos Santos V,
    4. et al
    . Cerebellar substructures and neurological soft signs in first-episode schizophrenia. Psychiatry Res 2009;173:83–87
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Tavano A,
    2. Grasso R,
    3. Gagliardi C,
    4. et al
    . Disorders of cognitive and affective development in cerebellar malformations. Brain 2007;130:2646–60
    Abstract/FREE Full Text
  38. 38.↵
    1. Blakemore SJ,
    2. Wolpert DM,
    3. Frith CD
    . Abnormalities in the awareness of action. Trends Cogn Sci 2002;6:237–42
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Pantelis C,
    2. Velakoulis D,
    3. McGorry PD,
    4. et al
    . Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 2003;361:281–88
    CrossRefPubMedWeb of Science
  40. 40.↵
    1. Peters BD,
    2. de Haan L,
    3. Vlieger EJ,
    4. et al
    . Recent-onset schizophrenia and adolescent cannabis use: MRI evidence for structural hyperconnectivity? Psychopharmacol Bull 2009;42:75–88
    PubMed
  41. 41.↵
    1. Dekker N,
    2. Schmitz N,
    3. Peters BD,
    4. et al
    . Cannabis use and callosal white matter structure and integrity in recent-onset schizophrenia. Psychiatry Res 2010;181:51–56
    CrossRefPubMedWeb of Science
  42. 42.↵
    1. Bava S,
    2. Frank LR,
    3. McQueeny T,
    4. et al
    . Altered white matter microstructure in adolescent substance users. Psychiatry Res 2009;173:228–37
    CrossRefPubMed
  43. 43.↵
    1. De Bellis MD,
    2. Van Voorhees E,
    3. Hooper SR,
    4. et al
    . Diffusion tensor measures of the corpus callosum in adolescents with adolescent onset alcohol use disorders. Alcohol Clin Exp Res 2008;32:395–404
    CrossRefPubMed
  44. 44.↵
    1. Arévalo-Martín A,
    2. García-Ovejero D,
    3. Rubio-Araiz A,
    4. et al
    . Cannabinoids modulate Olig2 and polysialylated neural cell adhesion molecule expression in the subventricular zone of post-natal rats through cannabinoid receptor 1 and cannabinoid receptor 2. Eur J Neurosci 2007;26:1548–59
    CrossRefPubMed
  45. 45.↵
    1. Alexander DC,
    2. Barker GJ,
    3. Arridge SR
    . Detection and modeling of non-Gaussian apparent diffusion coefficient profiles in human brain data. Magn Reson Med 2002;48:331–40
    CrossRefPubMedWeb of Science
  46. 46.↵
    1. Tournier JD,
    2. Yeh CH,
    3. Calamante F,
    4. et al
    . Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion-weighted imaging phantom data. Neuroimage 2008;42:617–25
    CrossRefPubMedWeb of Science
  47. 47.↵
    1. Miyata J,
    2. Sasamoto A,
    3. Koelkebeck K,
    4. et al
    . Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging. Hum Brain Mapp 2012;33:1741–49
    CrossRefPubMedWeb of Science
  48. 48.↵
    1. Good PI
    . Permutation, Parametric, and Bootstrap Tests of Hypotheses, 3rd ed. New York: Springer; 2005
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M. Filippi, E. Canu, R. Gasparotti, F. Agosta, P. Valsecchi, G. Lodoli, A. Galluzzo, G. Comi, E. Sacchetti
Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia
American Journal of Neuroradiology Jan 2014, 35 (1) 30-37; DOI: 10.3174/ajnr.A3583

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Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia
M. Filippi, E. Canu, R. Gasparotti, F. Agosta, P. Valsecchi, G. Lodoli, A. Galluzzo, G. Comi, E. Sacchetti
American Journal of Neuroradiology Jan 2014, 35 (1) 30-37; DOI: 10.3174/ajnr.A3583
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