Article Figures & Data
Figures
- Fig 1.
GABA-edited spectra from 5 subjects (all patients) obtained by using MEGA-PRESS sequence. NAA and coedited glutamate (glu) and glutamine (gln) can be seen in the spectra in addition to GABA.
- Fig 2.
Inverse correlation of sensorimotor γ-aminobutyric acid concentration and Nine-Hole Peg Test scores in patients with multiple sclerosis. A fixed error bar of 30% is used for [GABA] in the plot.
- Fig 3.
Correlation of sensorimotor γ-aminobutyric acid concentration and fMRI activation volume in patients with multiple sclerosis. A fixed error bar of 30% is used for [GABA] in the plot.
Tables
Voxel Composition [GABA]/[Cr] [Cr] (mM) [GABA] (mM) % GM % WM % CSF Controls (n = 10) 37 ± 7 52 ± 12 11 ± 8 0.15 ± 0.05 9.22 ± 0.85 1.43 ± 0.48 Patients (n = 13) 34 ± 7 49 ± 10 16 ± 5 0.19 ± 0.06 9.43 ± 1.43 1.71 ± 0.42 ↵a Values are means.
- Table 2:
Correlation coefficients of MSFC and components with GABA concentration and the ratio of GABA and Cr concentration
GABA MSFC GABA/Cr MSFC GABA 9HPT GABA/Cr 9HPT GABA T25FW GABA/Cr T25FW GABA PASAT GABA/Cr PASAT Controls (n = 10) −0.2233, P = .54 −0.1728, P = .63 0.1035, P = .78 0.1824, P = .61 −0.1680, P = .64 −0.0133, P = .97 −0.3341, P = .35 −0.3124, P = .38 Patients (n = 13) −0.3324, P = .27 −0.2052, P = .50 −0.6750,a P = .01 −0.4807, P = .1 −0.3865, P = .19 −0.4155, P = .16 0.0504, P = .87 0.1161, P = .71 Note:—MSFC indicates Multiple Sclerosis Functional Composite.
↵a Statistically significant.
