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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Sensorimotor Cortex Gamma-Aminobutyric Acid Concentration Correlates with Impaired Performance in Patients with MS

P.K. Bhattacharyya, M.D. Phillips, L.A. Stone, R.A. Bermel and M.J. Lowe
American Journal of Neuroradiology September 2013, 34 (9) 1733-1739; DOI: https://doi.org/10.3174/ajnr.A3483
P.K. Bhattacharyya
aFrom the Imaging Institute (P.K.B., M.D.P., M.J.L.)
bLerner College of Medicine (P.K.B., R.A.B.)
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M.D. Phillips
aFrom the Imaging Institute (P.K.B., M.D.P., M.J.L.)
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L.A. Stone
cDepartment of Neurology (L.A.S., R.A.B.), Cleveland Clinic, Cleveland, Ohio.
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R.A. Bermel
bLerner College of Medicine (P.K.B., R.A.B.)
cDepartment of Neurology (L.A.S., R.A.B.), Cleveland Clinic, Cleveland, Ohio.
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M.J. Lowe
aFrom the Imaging Institute (P.K.B., M.D.P., M.J.L.)
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Abstract

BACKGROUND AND PURPOSE: Abnormalities in GABA concentration [GABA] have been associated with several neuropsychiatric disorders, and research has suggested that GABA may play a role in sensorimotor cortex function. We sought to determine whether identifying a change in [GABA] within the sensorimotor cortex of patients with MS has any effect on motor function and would provide information about the adaptive/compensatory mechanisms involved in the attempt to maintain motor function during disease progression.

MATERIALS AND METHODS: In 19 healthy controls and 30 patients with MS, we assessed task performance with the MS Functional Composite scale and its components (T25FW test, 9HPT, and PASAT). With in vivo MR spectroscopy, we measured [GABA] in the sensorimotor cortex and determined correlations between [GABA] and task performance. We also assessed the association between [GABA] and cortical activation volume after a bilateral finger-tapping task.

RESULTS: [GABA] was inversely correlated with 9HPT scores in patients with MS, indicating a worsening of performance with increased [GABA]. No significant correlation was observed between [GABA] and T25FW or PASAT scores. [GABA] was directly correlated with primary motor cortex activation volume after the finger-tapping task in patients with MS.

CONCLUSIONS: These results suggest that cortical [GABA] may be a marker of function and reorganization/adaptation of cortical gray matter in MS.

ABBREVIATIONS:

9HPT
Nine-Hole Peg Test
GABA
γ-aminobutyric acid
GM
gray matter
PASAT
Paced Auditory Serial Addition Test
PRESS
point-resolved spectroscopy sequence
T25FW
Timed 25-Foot Walk Test
  • © 2013 by American Journal of Neuroradiology

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American Journal of Neuroradiology: 34 (9)
American Journal of Neuroradiology
Vol. 34, Issue 9
1 Sep 2013
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P.K. Bhattacharyya, M.D. Phillips, L.A. Stone, R.A. Bermel, M.J. Lowe
Sensorimotor Cortex Gamma-Aminobutyric Acid Concentration Correlates with Impaired Performance in Patients with MS
American Journal of Neuroradiology Sep 2013, 34 (9) 1733-1739; DOI: 10.3174/ajnr.A3483

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Sensorimotor Cortex Gamma-Aminobutyric Acid Concentration Correlates with Impaired Performance in Patients with MS
P.K. Bhattacharyya, M.D. Phillips, L.A. Stone, R.A. Bermel, M.J. Lowe
American Journal of Neuroradiology Sep 2013, 34 (9) 1733-1739; DOI: 10.3174/ajnr.A3483
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