Negative Predictive Value of Surveillance PET/CT in Head and Neck Squamous Cell Cancer

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Fig 1.
Data flow chart of patient selection.
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Fig 2.
Disease-free survival curve of patients with negative findings on PET-CT surveillance examinations after treatment for HNSCC. Time zero was chosen as the date of first PET/CT examination with negative findings.

Table 1:

Patient demographics, TNM stages, and therapy^{^a}

Note:—CRT indicates chemoradiation therapy; N, node; M, metastasis.
↵a A total of 512 patients were included in this study, but not all patients had initial staging data available, so fewer patients are included. The number of patients with available data is listed in the header for each section.

Table 2:

Primary site of origin and tumor stage^{^a}

Site of Origin	T1	T2	T3	T4
Oropharynx	25	42	21	30
Oral cavity	31	34	17	34
Larynx	10	15	21	11
Maxillofacial and sinus (parotid, skin, nasal cavity, orbit lip, sinus, maxilla)	5	5	5	10
Hypopharynx	4	4	9	5
Nasopharynx	0	1	1	6
Trans-spatial	0	2	2	6

↵a Fewer patients are listed in Table 2 than in Table 1 because some patients had incomplete data in the registry. Three patients had unknown primaries.

Table 4:

Clinical Information of the 19 patients with negative PET/CT findings who had a recurrence

Patient	Site of Origin	TNM Stage	Location of Recurrence	Time Interval between Negative PET/CT Findings and Recurrence (mo)
1	Oropharynx	T2N2cM0	Local	7.5
2	Maxillofacial	Not recorded	Regional	12.7
3	Oropharynx	T3N2cM0	Local	26.4
4	Oropharynx	Not recorded	Regional	7.5
5	Maxillofacial	Not recorded	Distant	11.4
6	Larynx	T2N0M0	Local	9.0
7	Unknown primary	T0N2bM0	Regional	27.5
8	Unknown primary	T0N2bM0	Regional	23.0
9	Hypopharynx	T4N2bM0	Local	6.9
10	Hypopharynx	T2N2bM0	Local	3.7
11	Larynx	T2N0M0	Local	3.0
12	Oropharynx	T3N0M0	Local	4.6
13	Oropharynx	T4N1M0	Local	9.5
14	Oral cavity	Not recorded	Distant	7.1
15	Oral cavity	T3N1M0	Regional	37.3
16	Oral cavity	T3N2cM0	Local	16.9
17	Oral cavity, larynx	T2N2cM0	Regional	4.8
18	Larynx	Not recorded	Local	12.3
19	Oral cavity	Not recorded	Local	12.7