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Research ArticleNeurointervention
Open Access

Intra-Arterial Infusion of a Glycoprotein IIb/IIIa Antagonist for the Treatment of Thromboembolism During Coil Embolization of Intracranial Aneurysm: A Comparison of Abciximab and Tirofiban

H.W. Jeong and S.-C. Jin
American Journal of Neuroradiology August 2013, 34 (8) 1621-1625; DOI: https://doi.org/10.3174/ajnr.A3501

Article Figures & Data

Figures

  • Fig 1.
    Fig 1.

    A 44-year-old man. A, Pre-embolization angiogram showing a recanalized left paraclinoid aneurysm. B, Postembolization angiogram showing the well-occluded aneurysm with 1 coil and arrested flow in the A2 segment of the left anterior cerebral artery. C, Final angiogram showing complete recanalization of the occluded branch after superselective intra-arterial infusion of abciximab (20 mg).

  • Fig 2.
    Fig 2.

    A 46-year-old woman. A, Pre-embolization angiogram showing a saccular aneurysm at the origin of the right SCA. B, Postembolization angiogram showing the well-occluded aneurysm with 3 detachable coils and occlusion of the right SCA. C, Final angiogram showing complete recanalization of the occluded right SCA after superselective intra-arterial infusion of tirofiban (0.2 mg).

Tables

  • Table 1:

    Summary of anatomic and clinical data of the abciximab group

    SexAge (y)HH GradeRupturedAneurysm LocationSize (mm)Affected VesselAffected Vessel FlowDose (mg)Final AngiographyFollow-Up Angiography
    Male644oLeft AcomA8.6 × 4.1Left A2Preserved15No changeComplete resolution
    Female603oRight AchA9.9 × 4.8Right distal ICAPreserved10No changeComplete resolution
    Male413oBasilar top3.5 × 5.0Both P1Preserved10Partial resolutionComplete resolution
    Female750xRight AcomA3.4 × 2.9Right A2Preserved10Partial resolutionComplete resolution
    Male610oRight pericallosal5.0 × 4.0Right callosomarginalPreserved10Partial resolutionComplete resolution
    Male540xRight SCA2.6 × 2.2Both SCADecreased20Partial resolutionPartial resolution
    Male532oRight AcomA8.3 × 5.2Right A2Preserved10Partial resolutionComplete resolution
    Male440xBasilar top4.8 × 4.5Left P1Arrested10No changeComplete resolution
    Male440xLeft paraclinoid3.6 × 3.6Left A2Arrested20Complete resolutionComplete resolution
    Female671xLeft ICA bifurcation12 × 12Left M1Arrested10M1 partial resolution M3 distal migrationM1 complete resolution M3 no change
    Female650xLeft SCA10.1 × 8.1Left SCADecreased10Partial resolutionPartial resolution

    • Note:—AcomA indicates anterior communicating artery; AchA, anterior choroidal artery; SCA, superior cerebellar artery.

  • Table 2:

    Summary of anatomic and clinical data of the tirofiban group

    SexAge (y)HH GradeRupturedAneurysm LocationSize (mm)Affected VesselAffected Vessel FlowDose (mg)Final AngiographyFollow-Up Angiography
    Female460xRight SCA4.7 × 4.2Right SCAArrested0.2Complete resolutionComplete resolution
    Female671xLeft paraclinoid3.8 × 4.0Left M4 (angular branch)Arrested0.2No changePartial resolution
    Female800xLeft ICA bifurcation4.5 × 7.0Left M2, left proximal A1Decreased0.6Partial resolutionComplete resolution
    Female610xRight SCA3.9 × 4.0Right SCADecreased1.0Partial resolutionPartial resolution
    Female402xAcomA5.2 × 3.4Left proximal A2Preserved0.3Partial resolutionComplete resolution
    Male332oAcomA7.0 × 5.5Left A2Arrested0.2Complete resolutionComplete resolution
    Female442xLeft AchA9.1 × 7.0Left M1Arrested1.0M1 complete resolution M3 distal migrationM1 complete resolution M3 no change
    Female650xAcomA8.0 × 6.5Left A2Preserved0.3Complete resolutionComplete resolution
    Female680xRight AchA3.5 × 3.1Right AchADecreased0.5Partial resolutionComplete resolution
    Female711xRight pericallosal3.3 × 1.9Right callosomarginalPreserved0.4Partial resolutionComplete resolution
    Male502oRight proximal A13.0 × 4.2Right proximal A1Decreased0.5Partial resolutionComplete resolution

    • Note:—SCA indicates superior cerebellar artery; AcomA, anterior communicating artery; AchA, anterior choroidal artery.

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Intra-Arterial Infusion of a Glycoprotein IIb/IIIa Antagonist for the Treatment of Thromboembolism During Coil Embolization of Intracranial Aneurysm: A Comparison of Abciximab and Tirofiban
H.W. Jeong, S.-C. Jin
American Journal of Neuroradiology Aug 2013, 34 (8) 1621-1625; DOI: 10.3174/ajnr.A3501
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