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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

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Imaging Features of Midface Injectable Fillers and Associated Complications

D.T. Ginat and C.J. Schatz
American Journal of Neuroradiology August 2013, 34 (8) 1488-1495; DOI: https://doi.org/10.3174/ajnr.A3161
D.T. Ginat
aFrom the Department of Radiology (D.T.G.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
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C.J. Schatz
bDepartment of Radiology (C.J.S.), Beverly Tower Wilshire Advanced Imaging, University of Southern California Keck School of Medicine, Los Angeles, California.
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    Fig 1.

    Calcium hydroxyapatite. Axial CT image (A) shows hyperattenuated material within the bilateral cheek subcutaneous tissues (arrows). Axial T1 (B) and T2 (C) MR images show that the fillers have low-to-intermediate signal on both sequences (arrows).

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    Fig 2.

    Calcium hydroxyapatite. Coronal 18FDG-PET image shows apparent hypermetabolism at the site of the fillers, which can be a false-positive finding for malignant disease (arrows).

  • Fig 3.
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    Fig 3.

    Collagen. Axial CT image (A) shows stranding in the bilateral cheek subcutaneous tissues (arrows). Axial T1 (B), postcontrast T1 (C), and fat-saturated T2 (D) MR images show that the filler has nearly fluid signal characteristics (arrows).

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    Fig 4.

    Liquid silicone. Axial CT image (A) shows numerous high-attenuation foci within the bilateral cheeks (arrows). Axial T1 (B) and T2 (C) MR images show corresponding intermediate signal on both sequences.

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    Fig 5.

    Polytetrafluoroethylene. Coronal CT image shows linear hyperattenuation in the bilateral nasolabial folds (arrows).

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    Fig 6.

    Hyaluronic acid gel. Axial T1 (A) and fat-suppressed postcontrast T1 (B) and T2 (C) MR images show bilateral fluid-intensity collections in the nasolabial folds, right greater than left (arrows).

  • Fig 7.
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    Fig 7.

    Poly-l-lactic acid. Axial CT image shows bilateral irregular soft-tissue attenuation, with surrounding stranding in the subcutaneous tissues of the cheeks.

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    Fig 8.

    Polyacrylamide gel. Axial T1 (A) and T2 (B) MR images show a cluster of fluid-intensity collections surrounded by thin hypointense capsules within the left buccal space (arrows).

  • Fig 9.
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    Fig 9.

    Abscess. The patient presented with painful swelling of right cheek after hyaluronic acid injection 2 months earlier. Axial (A) and coronal (B) T2, axial T1 (C), and coronal fat-saturated postcontrast T1 (D) MR images show deposits of hyaluronic acid in the bilateral oral commissures and upper lip (arrowheads). Posterior to the filler on the right, there is a multiloculated rim-enhancing fluid collection (arrows).

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    Fig 10.

    Overfilling. The patient presented with a facial lump and did not initially disclose a history of facial augmentation, which prompted imaging evaluation. A metallic marker was placed over the affected site. Axial CT images (A and B) show asymmetric contour deformity of the right nasolabial fold where there is a prominent deposit of filler agent. Courtesy of Gul Moonis, MD.

  • Fig 11.
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    Fig 11.

    Migration. The patient presented with an eyelid “mass” after hyaluronic acid injection in the cheeks. Axial (A), sagittal (B), and coronal (C) T1 and axial fat-suppressed T2 (D) MR images show a globular collection of hyaluronic acid within the inferior eyelid (arrow), which extends superiorly from large deposits of filler in the cheeks (arrowheads).

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    Fig 12.

    Chronic inflammation. The patient presented with right-greater-than-left facial swelling approximately 5 years after silicone injection. Axial T2 (A), T1 (B), and fat-saturated postcontrast T1 (C) MR images show an external marker overlying the lower right cheek (arrows), where there is diffuse swelling and enhancement surrounding the filler material. Milder involvement is also noted in the left side.

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    Fig 13.

    Scarring. The patient has a remote history of liquid silicone injection. Axial CT image shows fibrotic bands in the bilateral cheek subcutaneous tissues (arrows).

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    Fig 14.

    Foreign-body granuloma. The patient underwent silicone injection 50 years before. Axial CT image shows a nodule with eggshell calcification in the right cheek (arrow).

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American Journal of Neuroradiology: 34 (8)
American Journal of Neuroradiology
Vol. 34, Issue 8
1 Aug 2013
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Cite this article
D.T. Ginat, C.J. Schatz
Imaging Features of Midface Injectable Fillers and Associated Complications
American Journal of Neuroradiology Aug 2013, 34 (8) 1488-1495; DOI: 10.3174/ajnr.A3161

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Imaging Features of Midface Injectable Fillers and Associated Complications
D.T. Ginat, C.J. Schatz
American Journal of Neuroradiology Aug 2013, 34 (8) 1488-1495; DOI: 10.3174/ajnr.A3161
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  • Article
    • Abstract
    • Calcium Hydroxylapatite
    • Collagen and Collagen Mixed with Polymethylmethacrylate
    • Liquid Silicone
    • Polytetrafluoroethylene
    • Hyaluronic Acid
    • Poly-l-Lactic Acid
    • Polyacrylamide Gel
    • Complications
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