Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain

Automated Segmentation of Hippocampal Subfields in Drug-Naïve Patients with Alzheimer Disease

H.K. Lim, S.C. Hong, W.S. Jung, K.J. Ahn, W.Y. Won, C. Hahn, I.S. Kim and C.U. Lee
American Journal of Neuroradiology April 2013, 34 (4) 747-751; DOI: https://doi.org/10.3174/ajnr.A3293
H.K. Lim
aFrom the Departments of Psychiatry (H.K.L., S.C.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S.C. Hong
aFrom the Departments of Psychiatry (H.K.L., S.C.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W.S. Jung
bRadiology (W.S.J.), Saint Vincent Hospital, Suwon, College of Medicine, Catholic University of Korea, Suwon, Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K.J. Ahn
cDepartments of Radiology (K.J.A.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W.Y. Won
eDepartment of Psychiatry (W.Y.W.), Saint Paul's Hospital, Seoul, College of Medicine, Catholic University of Korea, Seoul, Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Hahn
dPsychiatry (C.H., C.U.L.), Seoul Saint Mary's Hospital, Seoul, College of Medicine, Catholic University of Korea, Seoul, Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
I.S. Kim
fSiemens Healthcare (I.S.K.), Seoul, Korea.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.U. Lee
dPsychiatry (C.H., C.U.L.), Seoul Saint Mary's Hospital, Seoul, College of Medicine, Catholic University of Korea, Seoul, Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Squire LR,
    2. Zola Morgan S
    . The medial temporal lobe memory system. Science 1991;253:1380–86
    Abstract/FREE Full Text
  2. 2.↵
    1. Braak H,
    2. Braak E
    . Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239–59
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Li S,
    2. Shi F,
    3. Pu F,
    4. et al
    . Hippocampal shape analysis of Alzheimer disease based on machine learning methods. AJNR Am J Neuroradiol 2007;28:1339–45
    Abstract/FREE Full Text
  4. 4.↵
    1. Yushkevich PA,
    2. Wang H,
    3. Pluta J,
    4. et al
    . Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI. Neuroimage 2010;53:1208–24
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Mueller SG,
    2. Weiner MW
    . Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields. Hippocampus 2009;19:558–64
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Hanseeuw BJ,
    2. Van Leemput K,
    3. Kavec M,
    4. et al
    . Mild cognitive impairment: differential atrophy in the hippocampal subfields. AJNR Am J Neuroradiol 2011;32:1658–61
    Abstract/FREE Full Text
  7. 7.↵
    1. Van Leemput K,
    2. Bakkour A,
    3. Benner T,
    4. et al
    . Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI. Hippocampus 2009;19:549–57
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Wang L,
    2. Harms MP,
    3. Staggs JM,
    4. et al
    . Donepezil treatment and changes in hippocampal structure in very mild Alzheimer disease. Arch Neurol 2010;67:99–106
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. McKhann G,
    2. Drachman D,
    3. Folstein M,
    4. et al
    . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939–44
    CrossRefPubMed
  10. 10.↵
    1. Morris JC
    . The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993;43:2412–14
    CrossRefPubMed
  11. 11.↵
    1. Dale AM,
    2. Fischl B,
    3. Sereno MI
    . Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 1999;9:179–94
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Fischl B,
    2. Dale AM
    . Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A 2000;97:11050–55
    Abstract/FREE Full Text
  13. 13.↵
    1. Raz N,
    2. Lindenberger U,
    3. Rodrigue KM,
    4. et al
    . Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex 2005;15:1676–89
    Abstract/FREE Full Text
  14. 14.↵
    1. Park J,
    2. Kwon Y
    . Modification of the Mini-Mental State Examination for use in the elderly in a non-western society. Part I. Development of Korean version of Mini-Mental State Examination. Int J Geriatr Psychiatry 1990;5:381–87
    CrossRefWeb of Science
  15. 15.↵
    1. Lee JH,
    2. Lee KU,
    3. Lee DY,
    4. et al
    . Development of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries. J Gerontol B Psychol Sci Soc Sci 2002;57:P47–53
    Abstract/FREE Full Text
  16. 16.↵
    1. Lyoo IK,
    2. Sung YH,
    3. Dager SR,
    4. et al
    . Regional cerebral cortical thinning in bipolar disorder. Bipolar Disord 2006;8:65–74
    CrossRef
  17. 17.↵
    1. Ashburner J,
    2. Csernansky JG,
    3. Davatzikos C,
    4. et al
    . Computer-assisted imaging to assess brain structure in healthy and diseased brains. Lancet Neurol 2003;2:79–88
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Braak E,
    2. Braak H
    . Alzheimer's disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon's horn. Acta Neuropathol 1997;93:323–25
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Mizutani T,
    2. Kasahara M
    . Hippocampal atrophy secondary to entorhinal cortical degeneration in Alzheimer-type dementia. Neurosci Lett 1997;222:119–22
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Malkova L,
    2. Mishkin M
    . One-trial memory for object-place associations after separate lesions of hippocampus and posterior parahippocampal region in the monkey. J Neurosci 2003;23:1956–65
    Abstract/FREE Full Text
  21. 21.↵
    1. Wisniewski HM,
    2. Sadowski M,
    3. Jakubowska Sadowska K,
    4. et al
    . Diffuse, lake-like amyloid-beta deposits in the parvopyramidal layer of the presubiculum in Alzheimer disease. J Neuropathol Exp Neurol 1998;57:674–83
    PubMedWeb of Science
  22. 22.↵
    1. Costafreda SG,
    2. Dinov ID,
    3. Tu Z,
    4. et al
    . Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment. Neuroimage 2011;56:212–19
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Duvernoy HM,
    2. Vannson LL,
    3. Cattin F
    . The Human Hippocampus, Functional Anatomy, Vascularization and Serial Sections with MRI. Berlin, Germany: Springer-Verlag; 2005
  24. 24.↵
    1. Frisoni GB,
    2. Sabattoli F,
    3. Lee AD,
    4. et al
    . In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study. Neuroimage 2006;32:104–10
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Simić G,
    2. Kostović I,
    3. Winblad B,
    4. et al
    . Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease. J Comp Neurol 1997;379:482–94
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Mueller SG,
    2. Schuff N,
    3. Yaffe K,
    4. et al
    . Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease. Human Brain Mapp 2010;31:1339–47
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 34 (4)
American Journal of Neuroradiology
Vol. 34, Issue 4
1 Apr 2013
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Automated Segmentation of Hippocampal Subfields in Drug-Naïve Patients with Alzheimer Disease
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
H.K. Lim, S.C. Hong, W.S. Jung, K.J. Ahn, W.Y. Won, C. Hahn, I.S. Kim, C.U. Lee
Automated Segmentation of Hippocampal Subfields in Drug-Naïve Patients with Alzheimer Disease
American Journal of Neuroradiology Apr 2013, 34 (4) 747-751; DOI: 10.3174/ajnr.A3293

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Automated Segmentation of Hippocampal Subfields in Drug-Naïve Patients with Alzheimer Disease
H.K. Lim, S.C. Hong, W.S. Jung, K.J. Ahn, W.Y. Won, C. Hahn, I.S. Kim, C.U. Lee
American Journal of Neuroradiology Apr 2013, 34 (4) 747-751; DOI: 10.3174/ajnr.A3293
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • CERAD (Consortium to Establish a Registry for Alzheimers Disease) Neuropsychology Assessment Battery: 35 Years and Counting
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire