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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleExpedited Publication

Clopidogrel Hyper-Response and Bleeding Risk in Neurointerventional Procedures

C. Goh, L. Churilov, P. Mitchell, R. Dowling and B. Yan
American Journal of Neuroradiology April 2013, 34 (4) 721-726; DOI: https://doi.org/10.3174/ajnr.A3418
C. Goh
aFrom the Department of Radiology (C.G., R.D.)
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L. Churilov
dDepartment of Mathematics and Statistics (L.C.), University of Melbourne, Melbourne, Australia
eNational Stroke Research Unit (L.C.), Florey Neuroscience Institute, Melbourne, Australia.
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P. Mitchell
bNeurointervention Service (R.D., P.M., B.Y.)
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R. Dowling
aFrom the Department of Radiology (C.G., R.D.)
bNeurointervention Service (R.D., P.M., B.Y.)
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B. Yan
bNeurointervention Service (R.D., P.M., B.Y.)
cComprehensive Stroke Centre (B.Y.), Royal Melbourne Hospital, Melbourne, Australia
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    Flow chart illustration of patient enrollment.

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    Fig. 2.

    The distribution among the study population of major and minor bleeding events and the level of platelet inhibition achieved.

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    Fig. 3.

    Percentage of platelet inhibition for patients with major or minor hemorrhagic complications, compared with those with no hemorrhagic complications.

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American Journal of Neuroradiology: 34 (4)
American Journal of Neuroradiology
Vol. 34, Issue 4
1 Apr 2013
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Cite this article
C. Goh, L. Churilov, P. Mitchell, R. Dowling, B. Yan
Clopidogrel Hyper-Response and Bleeding Risk in Neurointerventional Procedures
American Journal of Neuroradiology Apr 2013, 34 (4) 721-726; DOI: 10.3174/ajnr.A3418

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Clopidogrel Hyper-Response and Bleeding Risk in Neurointerventional Procedures
C. Goh, L. Churilov, P. Mitchell, R. Dowling, B. Yan
American Journal of Neuroradiology Apr 2013, 34 (4) 721-726; DOI: 10.3174/ajnr.A3418
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  • Short- versus long-term Dual AntiPlatelet Therapy for Stent-Assisted treatment of CErebral aneurysm (DAPTS ACE): a multicenter, open-label, randomized clinical trial
  • Short- versus long-term Dual AntiPlatelet Therapy for Stent-Assisted treatment of CErebral aneurysm (DAPTS ACE): a multicenter, open-label, randomized clinical trial
  • Safety of Oral P2Y12 Inhibitors in Interventional Neuroradiology: Current Status and Perspectives
  • Active management of the target P2Y12 reaction unit range in patients undergoing stent-assisted coil embolization for unruptured cerebral aneurysms
  • Dose adjustment of clopidogrel in hyper-responder patients with unruptured intracranial aneurysms treated with stents
  • Platelet reactivity and hemorrhage risk in neurointerventional procedures under dual antiplatelet therapy
  • Platelet function testing: does a randomized controlled trial settle the debate?
  • Association between CYP2C19 Polymorphisms and Outcomes in Cerebral Endovascular Therapy
  • Platelet Testing is Associated with Worse Clinical Outcomes for Patients Treated with the Pipeline Embolization Device
  • Use of thromboelastography to tailor dual-antiplatelet therapy in patients undergoing treatment of intracranial aneurysms with the Pipeline embolization device
  • Tailoring platelet inhibition according to multiple electrode aggregometry decreases the rate of thrombotic complications after intracranial flow-diverting stent implantation
  • Prospective Study of Early MRI Appearances following Flow-Diverting Stent Placement for Intracranial Aneurysms
  • Variability in initial response to standard clopidogrel therapy, delayed conversion to clopidogrel hyper-response, and associated thromboembolic and hemorrhagic complications in patients undergoing endovascular treatment of unruptured cerebral aneurysms
  • Platelet function inhibitors and platelet function testing in neurointerventional procedures
  • Carotid artery stenting outcomes: do they correlate with antiplatelet response assays?
  • Last-Recorded P2Y12 Reaction Units Value Is Strongly Associated with Thromboembolic and Hemorrhagic Complications Occurring Up to 6 Months after Treatment in Patients with Cerebral Aneurysms Treated with the Pipeline Embolization Device
  • Point of care platelet function testing in routine neurointerventional care is unjustified
  • Antiplatelet testing in neurointervention: we cannot ignore the signs
  • Platelet-Function Testing in Patients Undergoing Neurovascular Procedures: Caught between a Rock and a Hard Place
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