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Research ArticleFunctional

Application of a Computerized Language Lateralization Index from fMRI by a Group of Clinical Neuroradiologists

S.E. Jones, S.Y. Mahmoud, J. Gonzalez-Martinez, D.S. Lockwood, D. Moon, A.S. Smith, T.W. Stultz, A.L. Tievsky and M.D. Phillips
American Journal of Neuroradiology March 2013, 34 (3) 564-569; DOI: https://doi.org/10.3174/ajnr.A3271
S.E. Jones
aFrom the Divisions of Neuroradiology (S.E.J., S.Y.M., D.S.L., D.M., A.S.S., T.W.S., A.L.T., M.D.P.)
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S.Y. Mahmoud
aFrom the Divisions of Neuroradiology (S.E.J., S.Y.M., D.S.L., D.M., A.S.S., T.W.S., A.L.T., M.D.P.)
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J. Gonzalez-Martinez
bNeurosurgery (J.G.-M.), Imaging Institute, Cleveland Clinic, Cleveland Ohio.
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D.S. Lockwood
aFrom the Divisions of Neuroradiology (S.E.J., S.Y.M., D.S.L., D.M., A.S.S., T.W.S., A.L.T., M.D.P.)
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D. Moon
aFrom the Divisions of Neuroradiology (S.E.J., S.Y.M., D.S.L., D.M., A.S.S., T.W.S., A.L.T., M.D.P.)
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A.S. Smith
aFrom the Divisions of Neuroradiology (S.E.J., S.Y.M., D.S.L., D.M., A.S.S., T.W.S., A.L.T., M.D.P.)
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T.W. Stultz
aFrom the Divisions of Neuroradiology (S.E.J., S.Y.M., D.S.L., D.M., A.S.S., T.W.S., A.L.T., M.D.P.)
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A.L. Tievsky
aFrom the Divisions of Neuroradiology (S.E.J., S.Y.M., D.S.L., D.M., A.S.S., T.W.S., A.L.T., M.D.P.)
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M.D. Phillips
aFrom the Divisions of Neuroradiology (S.E.J., S.Y.M., D.S.L., D.M., A.S.S., T.W.S., A.L.T., M.D.P.)
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Article Figures & Data

Tables

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    Table 1:

    Inter-rater agreement of 8 neuroradiologists reviewing 22 language fMRI examinations, each with and without the use of CLIa

    Mean κ
    Without CLIWith CLI
    Overall lateralization0.640.70
    Overall quality0.110.08
    Overall noise0.050.07
    Overall confidence0.120.03
    • ↵a Measured parameters include overall lateralization, image quality, overall image noise, and subjective confidence of the lateralization conclusion. Lateralization was dichotomized for either left or nonleft.

    • View popup
    Table 2:

    Comparison of a neuroradiologist's subjective impression of language lateralization from fMRI compared with known lateralization, conducted without (top half) and with (bottom half) the use of CLIa

    Known LateralizationNeuroradiologist's Subjective Impression
    LeftNonleft
    Without CLI
        Left77 (0.44)11 (0.06)
        Nonleft28 (0.16)60 (0.34)
    With CLI
        Left81 (0.46)7 (0.04)
        Nonleft27 (0.15)61 (0.35)
    • ↵a The numbers refer to the total assessments obtained after review of all 8 neuroradiologists with all 22 studies, for a total of 176 comparisons. The number in parentheses is the corresponding fraction. Lateralization was dichotomized into 2 categories of either left or nonleft lateralization, with the latter group combining bilateral and right lateralization (ie, any examination with some component of right-sided activation).

    • View popup
    Table 3:

    Neuroradiologist's subjective impression of language lateralization, with trichotomized lateralization categories of left, bilateral, and righta

    Known LateralizationNeuroradiologist's Subjective Impression
    LeftBilateralRight
    Without CLI
        Left77 (0.44)11 (0.06)0 (0.00)
        Bilateral26 (0.15)12 (0.07)10 (0.06)
        Right2 (0.01)21 (0.12)17 (0.10)
    With CLI
        Left81 (0.46)7 (0.04)0 (0.00)
        Bilateral27 (0.15)11 (0.06)10 (0.06)
        Right0 (0.00)25 (0.14)15 (0.09)
    • ↵a Similar to Table 2. The top half displays results obtained without using CLI, while the bottom half displays results obtained using CLI. The number in parentheses is the corresponding fraction.

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American Journal of Neuroradiology: 34 (3)
American Journal of Neuroradiology
Vol. 34, Issue 3
1 Mar 2013
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S.E. Jones, S.Y. Mahmoud, J. Gonzalez-Martinez, D.S. Lockwood, D. Moon, A.S. Smith, T.W. Stultz, A.L. Tievsky, M.D. Phillips
Application of a Computerized Language Lateralization Index from fMRI by a Group of Clinical Neuroradiologists
American Journal of Neuroradiology Mar 2013, 34 (3) 564-569; DOI: 10.3174/ajnr.A3271

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Application of a Computerized Language Lateralization Index from fMRI by a Group of Clinical Neuroradiologists
S.E. Jones, S.Y. Mahmoud, J. Gonzalez-Martinez, D.S. Lockwood, D. Moon, A.S. Smith, T.W. Stultz, A.L. Tievsky, M.D. Phillips
American Journal of Neuroradiology Mar 2013, 34 (3) 564-569; DOI: 10.3174/ajnr.A3271
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