Article Figures & Data
Figures
- Fig 1.
SPM8 “glass brain” representation (A) of voxelwise analysis between control subjects and patients with Alzheimer disease showing significant clusters of decreased magnetization transfer ratio in the left hippocampus and amygdala and in the posterior mesial temporal cortex (fusiform gyrus) (P < .05, with family-wise error rate correction). Superimposition onto T1 template of the cluster in the hippocampus and amygdala are demonstrated in B and of the cluster in the fusiform gyrus in C.
- Fig 2.
Example of the FreeSurfer automatic VOI segmentation of the hippocampus (A) and amygdala (B) eroded with a 3D structural element with 1-mm radius.
- Fig 3.
Magnetization transfer ratio of in the hippocampi [left (A) and right (B)] and amygdalae [left (C) and right (D)] in the 3 groups. Mean and 95% confidence intervals of mean MT ratio are reported. The MT ratio in the bilateral hippocampus and amygdala was significantly lower in patients with Alzheimer disease when compared with control subjects (ANOVA with post hoc Bonferroni correction, with P < .05). The values of the mean MT ratio in the hippocampus and amygdala in the patients with amnestic mild cognitive impairment were between those of healthy control subjects and those of patients with mild AD, and the differences were not significant with the exception of the MT ratio in the left amygdala, which was significantly lower in AD than in amnestic MCI.
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