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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain

The Effect of Paramagnetic Contrast in Choline Peak in Patients with Glioblastoma Multiforme Might Not Be Significant

E.C. Lima, M.C.G. Otaduy, M. Tsunemi, R. Pincerato, E.F. Cardoso, S. Rosemberg, P.H. Aguiar, G.G. Cerri and C.C. Leite
American Journal of Neuroradiology January 2013, 34 (1) 80-84; DOI: https://doi.org/10.3174/ajnr.A3181
E.C. Lima
aFrom the Departments of Radiology (E.C.L., M.C.G.O., M.T., R.P., E.F.C., G.G.C., C.C.L.)
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M.C.G. Otaduy
aFrom the Departments of Radiology (E.C.L., M.C.G.O., M.T., R.P., E.F.C., G.G.C., C.C.L.)
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M. Tsunemi
aFrom the Departments of Radiology (E.C.L., M.C.G.O., M.T., R.P., E.F.C., G.G.C., C.C.L.)
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R. Pincerato
aFrom the Departments of Radiology (E.C.L., M.C.G.O., M.T., R.P., E.F.C., G.G.C., C.C.L.)
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E.F. Cardoso
aFrom the Departments of Radiology (E.C.L., M.C.G.O., M.T., R.P., E.F.C., G.G.C., C.C.L.)
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S. Rosemberg
bPathology (S.R.)
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P.H. Aguiar
cNeurosurgery (P.H.A.), University of Sao Paulo, Sao Paulo, Brazil.
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G.G. Cerri
aFrom the Departments of Radiology (E.C.L., M.C.G.O., M.T., R.P., E.F.C., G.G.C., C.C.L.)
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C.C. Leite
aFrom the Departments of Radiology (E.C.L., M.C.G.O., M.T., R.P., E.F.C., G.G.C., C.C.L.)
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    Fig 1.

    Patient 1. Glioblastoma multiforme: T1 before and after IV contrast injection and FLAIR before contrast.

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    Fig 2.

    Patient 1. Multivoxel 1H-MR spectroscopy covering the largest area of the tumor and the spectra obtained before and after IV contrast injection in the medial margin of the tumor.

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    Table 1:

    Mean values for the Cho peak distributed in the tumoral and contralateral normal areas and in the enhancing and nonenhancing tumoral voxels

    SNCho PreCho PostPLW PreLW PostP
    Normal contralateral1832408 ± 108384 ± 1040.1540.079 ± 0.0210.084 ± 0.0260.106
    Nonenhanced voxels1015472 ± 139515 ± 1600.0540.081 ± 0.0170.095 ± 0.0240.119
    Enhanced voxels1849500 ± 106487 ± 1080.5100.090 ± 0.0190.099 ± 0.0280.055
    • Note:—LW indicates line width; N, total number of voxels analyzed; S, number of subjects analyzed; Pre, precontrast; Post, postcontrast.

    • View popup
    Table 2:

    Mean values for the Cho peak maximum values distributed in the tumoral and contralateral normal areas and in the enhancing and nonenhancing tumoral voxels

    SNCho PreCho PostPLW PreLW PostP
    Normal contralateral1832430 ± 112402 ± 1000.1480.081 ± 0.0260.085 ± 0.0340.154
    Non enhanced voxels1015489 ± 159533 ± 1750.0770.084 ± 0.0180.095 ± 0.0280.172
    Enhanced voxels1849599 ± 170527 ± 2010.020*0.092 ± 0.0250.093 ± 0.0270.688
    • Note:—LW indicates line width; N, total number of voxels analyzed; S, number of subjects analyzed; Pre, precontrast; Post, postcontrast;

    • ↵* , statistically significant.

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American Journal of Neuroradiology: 34 (1)
American Journal of Neuroradiology
Vol. 34, Issue 1
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Cite this article
E.C. Lima, M.C.G. Otaduy, M. Tsunemi, R. Pincerato, E.F. Cardoso, S. Rosemberg, P.H. Aguiar, G.G. Cerri, C.C. Leite
The Effect of Paramagnetic Contrast in Choline Peak in Patients with Glioblastoma Multiforme Might Not Be Significant
American Journal of Neuroradiology Jan 2013, 34 (1) 80-84; DOI: 10.3174/ajnr.A3181

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The Effect of Paramagnetic Contrast in Choline Peak in Patients with Glioblastoma Multiforme Might Not Be Significant
E.C. Lima, M.C.G. Otaduy, M. Tsunemi, R. Pincerato, E.F. Cardoso, S. Rosemberg, P.H. Aguiar, G.G. Cerri, C.C. Leite
American Journal of Neuroradiology Jan 2013, 34 (1) 80-84; DOI: 10.3174/ajnr.A3181
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