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Research ArticleNeurointervention

Preliminary Experience with the Percutaneous Embolization of Juvenile Angiofibromas Using Only Ethylene-Vinyl Alcohol Copolymer (Onyx) for Preoperative Devascularization Prior to Surgical Resection

J.J. Gemmete, S. Patel, A.S. Pandey, S.E. Sullivan, E.L. McKean, L.J. Marentette and N. Chaudhary
American Journal of Neuroradiology October 2012, 33 (9) 1669-1675; DOI: https://doi.org/10.3174/ajnr.A3043
J.J. Gemmete
aFrom the Division of Interventional Neuroradiology (J.J.G., S.P., A.S.P., N.C.), Department of Radiology
bDepartment of Neurosurgery (J.J.G., A.S.P., S.E.S., L.J.M., N.C.)
cDivision of Cranial Base Surgery (J.J.G., S.E.S., E.L.M., L.J.M.), Department of Otolaryngology, University of Michigan Health System, Ann Arbor, Michigan.
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S. Patel
aFrom the Division of Interventional Neuroradiology (J.J.G., S.P., A.S.P., N.C.), Department of Radiology
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A.S. Pandey
aFrom the Division of Interventional Neuroradiology (J.J.G., S.P., A.S.P., N.C.), Department of Radiology
bDepartment of Neurosurgery (J.J.G., A.S.P., S.E.S., L.J.M., N.C.)
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S.E. Sullivan
bDepartment of Neurosurgery (J.J.G., A.S.P., S.E.S., L.J.M., N.C.)
cDivision of Cranial Base Surgery (J.J.G., S.E.S., E.L.M., L.J.M.), Department of Otolaryngology, University of Michigan Health System, Ann Arbor, Michigan.
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E.L. McKean
cDivision of Cranial Base Surgery (J.J.G., S.E.S., E.L.M., L.J.M.), Department of Otolaryngology, University of Michigan Health System, Ann Arbor, Michigan.
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L.J. Marentette
bDepartment of Neurosurgery (J.J.G., A.S.P., S.E.S., L.J.M., N.C.)
cDivision of Cranial Base Surgery (J.J.G., S.E.S., E.L.M., L.J.M.), Department of Otolaryngology, University of Michigan Health System, Ann Arbor, Michigan.
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N. Chaudhary
aFrom the Division of Interventional Neuroradiology (J.J.G., S.P., A.S.P., N.C.), Department of Radiology
bDepartment of Neurosurgery (J.J.G., A.S.P., S.E.S., L.J.M., N.C.)
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    Fig 1.

    A 16-year-old boy who presented with epistaxis and nasal stuffiness with a Fisch grade IIIa juvenile angiofibroma. A, Coronal contrast-enhanced T1-weighted MR image shows a large contrast-enhancing mass within the right nasal cavity, extending into the right ethmoid sinus, right maxillary sinus, and right buccal space. B, Lateral right internal carotid angiogram (RICA) shows supply to the upper portion of the hypervascular mass from the inferior lateral trunk. C, Lateral right external carotid angiogram (RECA) shows the hypervascular mass with supply off the distal right internal maxillary artery, accessory meningeal artery, facial artery, and ascending pharyngeal artery. D, Lateral radiography shows the EVOH (Onyx) cast within the tumor. E, Lateral RECA postembolization shows no filling of the hypervascular mass.

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    Fig 2.

    A 13-year-old boy with nasal stuffiness and a Fisch Ib juvenile angiofibroma. A, Coronal contrast-enhanced T1-weighted MR image shows a contrast-enhancing mass within the left nasal cavity and posterior nasopharynx, extending into the left sphenoid sinus. B, Lateral left common carotid angiogram (LCCA) shows the hypervascular mass with supply off the ECA and ICA branches. C, Lateral DynaCT (Siemens, Erlangen, Germany) image shows the EVOH (Onyx) cast within the tumor. D, Lateral LCCA postembolization shows no filling of the hypervascular mass.

Tables

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    PatientTumor Size (AP × Trans × CC) (Maximum cm)Amount of Onyx (mL)No. of Needles in TumorFisch/Radowski GradeRoom Time for Preop Embo (min)Surgical ApproachRoom Time for Surgery (min)EBL (mL)Blood Transfusion
    16.0 × 6.1 × 4.8235IIIa/IIIA195Lefort I ENE38617002 U PRBC
    26 × 5.4 × 5.3162IIIa/IIIA279ENE47616002 U PRBC
    33.4 × 4.3 × 3.9255IVa/IIIB240ENE503400None
    43.8 × 3.3 × 4.0161IIIa/IIIA140ENE381400None
    56.4 × 3.2 × 3.3221IIIa/IIIA279ENE488400None
    62.3 × 2.1 × 1.421I/IA76NE3910None
    75.9 × 5.4 × 5.0101IIIa/IIIA125Midface deglove/medial maxillectomy223200None
    84.3 × 2.1 × 3.3142II/IIA157ENE192200None
    94.5 × 4.3 × 4.942I/IB123NE267200None
    • Note:—AP indicates anteroposterior; CC, craniocaudal; Preop Embo, preoperative embolization; NE, nasal endoscopic; Trans, transverse.

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American Journal of Neuroradiology: 33 (9)
American Journal of Neuroradiology
Vol. 33, Issue 9
1 Oct 2012
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J.J. Gemmete, S. Patel, A.S. Pandey, S.E. Sullivan, E.L. McKean, L.J. Marentette, N. Chaudhary
Preliminary Experience with the Percutaneous Embolization of Juvenile Angiofibromas Using Only Ethylene-Vinyl Alcohol Copolymer (Onyx) for Preoperative Devascularization Prior to Surgical Resection
American Journal of Neuroradiology Oct 2012, 33 (9) 1669-1675; DOI: 10.3174/ajnr.A3043

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Preliminary Experience with the Percutaneous Embolization of Juvenile Angiofibromas Using Only Ethylene-Vinyl Alcohol Copolymer (Onyx) for Preoperative Devascularization Prior to Surgical Resection
J.J. Gemmete, S. Patel, A.S. Pandey, S.E. Sullivan, E.L. McKean, L.J. Marentette, N. Chaudhary
American Journal of Neuroradiology Oct 2012, 33 (9) 1669-1675; DOI: 10.3174/ajnr.A3043
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