Article Figures & Data
Figures
- Fig 1.
Cohort populations selection process.
- Fig 2.
Comparison of severe renal dysfunction in the derivation and validation cohorts according to Renal Risk Score categories.
- Fig 3.
A, Receiver operating characteristic curve for predicting severe renal dysfunction in the RCSN cohort (model 1). B, Receiver operating characteristic curve for predicting severe renal dysfunction in the OSA cohort.
Tables
Values The variable a takes on the following values on the basis of race: Black Women = 166 Men = 163 White/other Women = 144 Men = 141 The variable b takes on the following values on the basis of sex: Women = 0.7 Men = 0.9 The variable c takes on the following values on the basis of sex and creatinine measurement: Women Serum creatinine, ≤0.7 mg/dL = −0.329 Serum creatinine, >0.7 mg/dL = −1.209 Men Serum creatinine, ≤0.9 mg/dL = −0.411 Serum creatinine, >0.9 mg/dL = −1.209 Variable RCSN3 2003–2008 OSA 2002/03 and 2004/05 Comparison of all Patients from RCSN versus OSA (P value) All (n = 9872) GFR ≥30 (n = 9393) GFR <30 (n = 479) P Value All (n = 2544) GFR ≥30 (n = 2411) GFR <30 (n = 133 ) P Value Age Median (IQR) (yr) 75 (65–83) 74 (64–82) 82 (77–88) <.0001 77 (68–83) 76 (67–83) 82 (77–87) <.0001 <.0001 ≥65 yr (No.) (%) 7389 (74.8) 6936 (73.8) 453 (94.6) <.0001 2066 (81.2) 1936 (80.3) 130 (97.7) <.0001 <.0001 No. of women (No.) (%) 4827 (48.9) 4827 (48.9) 294 (61.4) <.0001 1258 (49.4) 1177 (48.8) 81 (60.9) .007 .62 Stroke type (No.) (%) <.0001 .005 <.0001 Ischemic stroke 5496 (55.7) 5175 (55.1) 321 (67.0) 1101 (43.3) 1026 (42.6) 75 (56.4) TIA 3307 (33.5) 3176 (33.8) 131 (27.3) 1251 (49.2) 1198 (49.7) 53 (39.8) ICH 1069 (10.8) 1042 (11.1) 27 (5.6) 192 (7.5) 187 (7.8) ≤5 (≤3.8) Diabetes mellitus (No.) (%) 2178 (22.1) 2033 (21.6) 145 (30.3) <.0001 549 (21.6) 497 (20.6) 52 (39.1) <.0001 .60 Hypertension (No.) (%) 6552 (66.4) 6159 (65.6) 393 (82.0) <.0001 1512 (59.4) 1417 (58.8) 95 (71.4) .004 <.0001 Hyperlipidemia (No.) (%) 3478 (35.2) 3298 (35.1) 180 (37.6) .27 718 (28.2) 684 (28.4) 34 (25.6) .48 <.0001 Peripheral vascular disease (No.) (%) 529 (5.4) 483 (5.1) 46 (9.6) <.0001 105 (4.1) 92 (3.8) 13 (9.8) .0008 .01 Current smoking (No.) (%) 1481 (15.0) 1450 (15.4) 31 (6.5) <.0001 313 (12.3) 304 (12.6) 9 (6.8) .046 .0006 Previous myocardial infarction (No.) (%) 1492 (15.1) 1382 (14.7) 110 (23.0) <.0001 381 (15.0) 343 (14.2) 38 (28.6) <.0001 .86 Previous stroke or TIA (No.) (%) 3357 (34.0) 3149 (33.5) 208 (43.4) <.0001 979 (38.5) 919 (38.1) 60 (45.1) 011 <.0001 Preadmission medications (No.) (%): Metformin 1038 (10.5) 1006 (10.7) 32 (6.7) .005 253 (9.9) 237 (9.8) 16 (12.0) .41 .40 Insulin 414 (4.2) 368 (3.9) 46 (9.6) <.0001 99 (3.9) 84 (3.5) 15 (11.3) <.0001 .49 Note:—ICH indicates intracerebral hemorrhage.
- Table 3:
Results of multivariable logistic regression analyses using data from the RCSN (model 1)
Variable Unit OR (95% CI) Estimate β Age Estimate β Age Points Assigned Age (yr) 1 1.07 (1.06–1.08) 0.0688 0.0688 1 1 (per yr) Female sex 1 1.27 (1.04–1.54) 0.2362 0.0688 3.44 5 History of diabetes mellitus 1 1.34 (1.06–1.69) 0.292 0.0688 4.25 5 Preadmission insulin use 1 2.52 (1.74–3.67) 0.9255 0.0688 13.46 15 History of hypertension 1 1.86 (1.46–2.37) 0.6219 0.0688 9.05 10 - Table 4:
Results of multivariable logistic regression analyses using data from the RCSN (model 2)
Variable Unit OR (95% CI) Estimate β Age Estimate/β Age Points Assigned Age (yr) 1 1.07 (1.06–1.08) 0.0685 0.0685 1 1 (per yr) Female sex 1 1.32 (1.09–1.61) 0.2801 0.0685 4.09 5 History of diabetes mellitus 1 1.31 (1.03–1.66) 0.2682 0.0685 3.92 5 Preadmission insulin use 1 2.35 (1.61–3.42) 0.8545 0.0685 12.47 15 History of hypertension 1 1.80 (1.41–2.29) 0.5866 0.0685 8.56 10 Previous myocardial infarction 1 1.41 (1.12–1.77) 0.3425 0.0685 5.00 5 Peripheral vascular disease 1 1.70 (1.23–2.36) 0.5313 0.0685 7.75 10 Renal Risk Score Cutoff Severe Renal Dysfunction (GFR < 30) RCSN3 (n/N) (%) OSA (n/N) (%) P Value 10–60 ≤5/981 (≤0.005) ≤5/196 (≤0.03) .84 61–70 7/1011 (0.7) ≤5/210 (≤0.02) .72 71–80 34/1622 (2.1) 10/457 (2.2) .90 81–90 91/2488 (3.7) 33/731 (4.5) .29 91–100 180/2519 (7.1) 44/665 (6.6) .64 101–110 132/1055 (12.5) 33/249 (13.3) .75 111–120 29/182 (15.9) 9/32 (28.1) .10 121–130 – – .13 Note:— – indicates small cell number (≤5).
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